DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and NOT3

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_012226.3	Gene:	NOT3 / 854773	SGDID:	S000001300	Length:	836	Species:	Saccharomyces cerevisiae

Alignment Length:	421	Identity:	102/421 - (24%)
Similarity:	143/421 - (33%)	Gaps:	131/421 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  6013 VPTTRPFEASTPSPASLKTTVPSVTSEATTNVPIGSTGQRIGTTPSESPETPTTLPSDFTTRPHS 6077
            :|...|  :|||||.                :|:....:....:||.||....|.|.:....  |
Yeast   297 IPVAGP--SSTPSPV----------------IPVADASKETERSPSSSPIHNATKPEEAVKT--S 341

  Fly  6078 EKTTESTRD--VPTTRPFETSTPSPASLETTVPSVTLETTTNV--PIGSTGGQVTEQTTSSPS-- 6136
            .|:..|:.|  :|             ||:.:..|.|.||.|||  .|..|...:|..||..|:
Yeast   342 IKSPRSSADNLLP-------------SLQKSPSSATPETPTNVHTHIHQTPNGITGATTLKPATL 393

  Fly  6137 ------EVRTTIRVEESTLPSR---SADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTR 6192
                  |::..:...::....|   ||..|..:.|.:|||..:..||..::.....|..:.|
Yeast   394 PAKPAGELKWAVAASQAVEKDRKVTSASSTISNTSTKTPTTAAATTTSSNANSRIGSALNTP--- 455

  Fly  6193 PFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQ-------------------TTAPPS- 6237
              :.|| |..||:......:|...|...:.:.|.....|                   .|.|.|
Yeast   456 --KLST-SSLSLQPDNTGASSSAATAAAVLAAGAAAVHQNNQAFYRNMSSSHHPLVSLATNPKSE 517

  Fly  6238 -EVRTTI---GVEESTLPSRSTDRTSPSESPE------TPT--TLPSDFITRPHSEQTTESTRDV 6290
             ||.||:   |.|.:|   :........||||      .||  ....||          ||.||
Yeast   518 HEVATTVNQNGPENTT---KKVMEQKEEESPEERNKLQVPTFGVFDDDF----------ESDRD- 568

  Fly  6291 PTTRPFE---ASTPSPASLKTTVPSVTSEATTNVPIGSTGGQVTEQTTSS------PSEVRTTI- 6345
            ..|.|.|   .|||...||:      ..||.||        ::.::..|.      ||.|:..|
Yeast   569 SETEPEEEEQPSTPKYLSLE------QREAKTN--------EIKKEFVSDFETLLLPSGVQEFIM 619

  Fly  6346 -------RVEESTLPSRSTDRTTPSESPETP 6369
                   ::|......||.|....|...|.|
Yeast   620 SSELYNSQIESKITYKRSRDMCEISRLVEVP 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395	102/421 (24%)
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572	43/172 (25%)
		DUF4758	6181..6360	CDD:292572	54/227 (24%)
		DUF4696	6339..6999	CDD:292395	10/39 (26%)
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
NOT3	NP_012226.3	Not3	2..230	CDD:397951
		PHA03247	<293..399	CDD:223021	34/134 (25%)
		NOT2_3_5	<691..782	CDD:398019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910