DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and NUP100

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_012855.1	Gene:	NUP100 / 853796	SGDID:	S000001551	Length:	959	Species:	Saccharomyces cerevisiae

Alignment Length:	589	Identity:	118/589 - (20%)
Similarity:	199/589 - (33%)	Gaps:	146/589 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  7716 TTTNVPIG----STVTSETTTNV----PIGSTGGQVAGQTTAPPSEVRTTIRVEESTLPSR---- 7768
            |.:|..||    :....:.:|.:    |.|:||....|.::..|:.:..|..|..|...|:
Yeast   372 TQSNTGIGLFGQNNNQQQQSTGLFGAKPAGTTGSLFGGNSSTQPNSLFGTTNVPTSNTQSQQGNS 436

  Fly  7769 --SADRTTPSESPETPTTLPSD-----FTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVP 7826
              .|.:.|.......||...|.     |.|:|.|  ||.|.        |..:|.|     ||||
Yeast   437 LFGATKLTNMPFGGNPTANQSGSGNSLFGTKPAS--TTGSL--------FGNNTAS-----TTVP 486

  Fly  7827 SV---------TSETTTNVPI----------GSTGGQLTEQSTSSPSEVRTTIRVEESTLPSR-- 7870
            |.         .|.:|||..:          .:.||.|...|.|:.|.:.....|...|..:.
Yeast   487 STNGLFGNNANNSTSTTNTGLFGAKPDSQSKPALGGGLFGNSNSNSSTIGQNKPVFGGTTQNTGL 551

  Fly  7871 ------------STDRTFPSESPEKPTTLPSDFTTRPHLEQTTESTRDVLTTRPFETSTPSPVSL 7923
                        ||.:.|...:    .||.......|.:..||::.  :|.|....:...:||:.
Yeast   552 FGATGTNSSAVGSTGKLFGQNN----NTLNVGTQNVPPVNNTTQNA--LLGTTAVPSLQQAPVTN 610

  Fly  7924 ETTVPSVTSETSTNVPIGSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATRVPL 7988
            |.....::...|...|:.:|..:|........|:  |.....:..|..:|.:...::.......|
Yeast   611 EQLFSKISIPNSITNPVKATTSKVNADMKRNSSL--TSAYRLAPKPLFAPSSNGDAKFQKWGKTL 673

  Fly  7989 ESTTRLYTDQTIPPGSTDRTTSSERPDESTRLTSEE-------------STETTRPVPTVSPRDA 8040
            |.:.|         ||:  |::|....||:.|.|.:             ..:..:.:..::..|.
Yeast   674 ERSDR---------GSS--TSNSITDPESSYLNSNDLLFDPDRRYLKHLVIKNNKNLNVINHNDD 727

  Fly  8041 LETTVTSLITETTKT------TSGGTPRGQVTERTTKSVSELTTGRSSDVVTERTMPSNISSTTT 8099
             |.:...|:|.||::      .|......::||:.....::|...........::...|.|::..
Yeast   728 -EASKVKLVTFTTESASKDDQASSSIAASKLTEKAHSPQTDLKDDHDESTPDPQSKSPNGSTSIP 791

  Fly  8100 VFNNSEPVSDNLPTTISITVTDSPTTVPVPTCKTDYDCLDEQTCIGGQCISPCEYFTNLCTVQNL 8164
            :..| |.:|..:|..:|..||         ..|.:|........:|.:.:      ..|..:.||
Yeast   792 MIEN-EKISSKVPGLLSNDVT---------FFKNNYYISPSIETLGNKSL------IELRKINNL 840

  Fly  8165 TICRTLNHTTKCYCDTDDDVNRPDCSMKAEIGCASSDECPSQQACINALCVDPCTFN-NPCSRNE 8228
            .|... |:....:.:..|.:|.|                      ::.||.|..||. ..||..|
Yeast   841 VIGHR-NYGKVEFLEPVDLLNTP----------------------LDTLCGDLVTFGPKSCSIYE 882

  Fly  8229 DCRV 8232
            :|.:
Yeast   883 NCSI 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395	66/299 (22%)
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572	44/213 (21%)
		DUF4758	7946..8126	CDD:292572	35/198 (18%)
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
NUP100	NP_012855.1	Nucleoporin_FG2	54..>246	CDD:406391
		ser_rich_anae_1	<290..>566	CDD:411418	48/208 (23%)
		Nucleoporin_FG	429..509	CDD:404514	25/94 (27%)
		Nucleoporin2	814..955	CDD:397975	20/102 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910