DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and ECM25

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_012334.1	Gene:	ECM25 / 853229	SGDID:	S000003737	Length:	599	Species:	Saccharomyces cerevisiae

Alignment Length:	304	Identity:	66/304 - (21%)
Similarity:	109/304 - (35%)	Gaps:	69/304 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  5900 HSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGST--------GGQVTGQTT 5956
            |.:.|...:|.:.     :|.||:...     ..::..|...:.|||.        ..::..:.:
Yeast   309 HGESTKHDSRTLS-----KALTPALCK-----EKLSMMTNDRLAIGSRYIKNLLDFFPEIAKEIS 363

  Fly  5957 APPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEQTTESTRDVPTTRPFEA 6021
            :|||.|.::     ||:|.....|.|   ||...:.|  ..:|.|.|.
Yeast   364 SPPSSVSSS-----STIPVLPKPRKS---SPTRYSEL--GCLTLPRSR----------------- 401

  Fly  6022 STPSPASLKTTVPSVTSEATTNVPI--GSTGQRIGTTPSESPETPTTLPSDFTTRPHSEKTTEST 6084
             :||| ....|.|:.|..|..|.|:  ..:..|..::||.:.:.|  ||....|||....|:.|.
Yeast   402 -SPSP-QRSVTSPTYTPVALQNTPVLKPKSSSRNVSSPSFNAKPP--LPIKAVTRPQLSLTSNSN 462

  Fly  6085 RDV------PTTRPFETSTPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIR 6143
            .|:      ..|....|.|||..||..:..|..|..:.|:.     ..|.::.....:.|.|.|.
Yeast   463 TDLALASSSTDTLSSPTKTPSADSLPLSNSSTDLTISDNIK-----EMVKDEPAKDKNSVETDIF 522

  Fly  6144 VEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRD 6187
            |::       .:..|..::.:......:...:....:||..|.|
Yeast   523 VQQ-------FESLTLVQNAKIKKFDKELQEKKKKNETTSKTAD 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395	66/304 (22%)
		DUF4758	5802..5979	CDD:292572	17/86 (20%)
		DUF4758	5964..6171	CDD:292572	48/214 (22%)
		DUF4758	6181..6360	CDD:292572	4/7 (57%)
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
ECM25	NP_012334.1	CRAL_TRIO_2	21..167	CDD:404584
		RhoGAP	190..359	CDD:214618	10/59 (17%)
		Herpes_BLLF1	<376..>519	CDD:282904	42/173 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910