DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and CRH1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_011705.1	Gene:	CRH1 / 853102	SGDID:	S000003421	Length:	507	Species:	Saccharomyces cerevisiae

Alignment Length:	611	Identity:	127/611 - (20%)
Similarity:	203/611 - (33%)	Gaps:	184/611 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  4428 TTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPF 4492
            |..|.|.:.:|....|||   .:||.||.:.|..:...|           |||..|.|......|
Yeast     8 TVLSASSLLSTFAAAEST---ATADSTTAASSTASCNPL-----------KTTGCTPDTALATSF 58

  Fly  4493 EASTPSSASLETTVPSVTLETTTNVPIGSTGGQVT-EQTTSSPS----------EVRTTIRVEES 4546
            .....||:...|     .|:....:..||.|..:| .:...:||          ::...::....
Yeast    59 SEDFSSSSKWFT-----DLKHAGEIKYGSDGLSMTLAKRYDNPSLKSNFYIMYGKLEVILKAANG 118

  Fly  4547 T-------LPS-----------------------RSADRTTLSESP----ETPTTLPSDFTIRPH 4577
            |       |.|                       ...|.||.....    :|||....::|:...
Yeast   119 TGIVSSFYLQSDDLDEIDIEWVGGDNTQFQSNFFSKGDTTTYDRGEFHGVDTPTDKFHNYTLDWA 183

  Fly  4578 SEQTT-----ESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPS 4637
            .::||     ||.|.:..|.. |....||..|...:.:..........|...||: |....||
Yeast   184 MDKTTWYLDGESVRVLSNTSS-EGYPQSPMYLMMGIWAGGDPDNAAGTIEWAGGE-TNYNDAP-- 244

  Fly  4638 EFRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTTRPFEASTPS 4702
               .|:.:|:..:...||.:                  ..||.||                 :.|
Yeast   245 ---FTMYIEKVIVTDYSTGK------------------KYTYGDQ-----------------SGS 271

  Fly  4703 PASLETTVPSV---TLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSE 4764
            ..|:|....|:   ..:...:..:.:.||.::..:|||     :|:....|:..|.|...|..|.
Yeast   272 WESIEADGGSIYGRYDQAQEDFAVLANGGSISSSSTSS-----STVSSSASSTVSSSVSSTVSSS 331

  Fly  4765 SPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTG 4829
            :..|.::..|..::...|..::.||            :|||:   |...|.|| .:::|...|:.
Yeast   332 ASSTVSSSVSSTVSSSSSVSSSSST------------SPSSS---TATSSKTL-ASSSVTTSSSI 380

  Fly  4830 GQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDV 4894
            ....:|::||..:...:....||.:           .|.:||.|:.|          ||.|| ..
Yeast   381 SSFEKQSSSSSKKTVASSSTSESII-----------SSTKTPATVSS----------TTRST-VA 423

  Fly  4895 PTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGG------QVTEQTTSSPSEVRTTIRVEE 4953
            |||:....|:.|                   |:...||      .||..||...|:..:||  :.
Yeast   424 PTTQQSSVSSDS-------------------PVQDKGGVATSSNDVTSSTTQISSKYTSTI--QS 467

  Fly  4954 STLPSRSTDRTTPSESPETPTTLPSD 4979
            |:..:.||:....|...:...:||.:
Yeast   468 SSSEASSTNSVQISNGADLAQSLPRE 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	59/299 (20%)
		DUF4758	4275..4448	CDD:292572	7/19 (37%)
		DUF4758	4377..4574	CDD:292572	38/190 (20%)
		DUF4758	4581..4754	CDD:292572	35/180 (19%)
		DUF4758	4683..4847	CDD:292572	32/166 (19%)
		DUF4758	4785..4964	CDD:292572	43/184 (23%)
		DUF4696	4841..5385	CDD:292395	32/145 (22%)
		DUF4758	4887..5098	CDD:292572	25/99 (25%)
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CRH1	NP_011705.1	GH16_fungal_CRH1_transglycosylase	74..258	CDD:185692	34/190 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910