DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and SPC105

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_011422.1	Gene:	SPC105 / 852787	SGDID:	S000003061	Length:	917	Species:	Saccharomyces cerevisiae

Alignment Length:	507	Identity:	102/507 - (20%)
Similarity:	172/507 - (33%)	Gaps:	114/507 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  4006 ESYKTTKQLSSNPETETPTTLPSRPTTRPFTDQTTEFTSEIPTITPMEGSTPTPSHLETTVASIT 4070
            :|.:.|.....||....||    |..|:......:..||.|.|           |:|::.|....
Yeast    27 QSSQMTSSFLENPGVRIPT----RIITKKEVLDGSNTTSRINT-----------SNLQSMVKRRV 76

  Fly  4071 SESTTREVYTIKPFDRSTPTPVSPDTTVPSITFETTTNIPIGTTRGQVTEQTTSSPSEKRTTIRV 4135
            |                    .:||.|:.|.||....|..|...|.:.|  :|:||    |.|..
Yeast    77 S--------------------FAPDVTLHSFTFVPEQNNEIKEPRRRKT--STNSP----TKISS 115

  Fly  4136 EESTL-------PSRSTDRTTPSESPET-------PTILPSDSTTRTYSDQTTESTRDVPTTRPF 4186
            :|..|       .:|:.::|...|.|:|       |.:...||...:..|.|:           .
Yeast   116 QEEPLVTSTQIDDARTEEKTAAEEDPDTSGMELTEPIVATPDSNKASQHDPTS-----------M 169

  Fly  4187 EASTPSPASLETTVPSVTLETTTN----DPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSRST 4247
            |.:...|.|:....|.|..|:..:    |.:.:...:..|.|  :...|.....:.:.|:.....
Yeast   170 EMTEVFPRSIRQKNPDVEGESIESSQQIDDVEAVREETMELT--AIHNVHDYDSISKDTVEGEPI 232

  Fly  4248 DRTTPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSSASLETT-------VPSV 4305
            |.|.....|..|.::...  |...||.:.|.:.|.......|..|.||..:|.|       ...:
Yeast   233 DLTEYESKPYVPNSVSRS--TGKSSDYSVERSNDKSDLSKSENKTNSSQPMEITDIFHADPQNPM 295

  Fly  4306 TLETTTNVPIGSTGGQVTEQTTS----------SPSE---VRTTIRVEESTLPSRSADRTTPSES 4357
            :|.:..|:.......::|:..|:          ||||   ..:..|.:..|:...:|..|||.:.
Yeast   296 SLHSDNNINNDGNEMELTQIQTNFDRDNHHIDESPSEKHAFSSNKRRKLDTVSDYAASVTTPVKE 360

  Fly  4358 PETPTTLPSDFTTRPHSEQTTESTRDVPT---TRPFEASTPSPASLETTVPSVTLETTTNVPIGS 4419
            .:..:...:|.......:.:..:..||..   ||..:..|..|.:.:|.:.:.|.:......:..
Yeast   361 AKDTSGEDNDGDLEMMEKMSPITFSDVDNKIGTRSNDVFTIEPGTEDTGMQTATDDEEDGENVDD 425

  Fly  4420 TGGQVTGQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFI 4471
            .|.::                ||::.||....:..:....|....|| .:||
Yeast   426 NGNKI----------------VEKTRLPEIDKEGQSGIALPTQDYTL-REFI 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572	46/211 (22%)
		DUF4696	4127..4678	CDD:292395	73/386 (19%)
		DUF4758	4275..4448	CDD:292572	35/195 (18%)
		DUF4758	4377..4574	CDD:292572	18/98 (18%)
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
SPC105	NP_011422.1	Spc7_N	70..>424	CDD:373822	78/394 (20%)
SPC105	NP_011422.1	Spc7	450..756	CDD:197874	5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910