DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and LTBP4

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001036009.1 Gene:LTBP4 / 8425 HGNCID:6717 Length:1624 Species:Homo sapiens


Alignment Length:1705 Identity:420/1705 - (24%)
Similarity:549/1705 - (32%) Gaps:688/1705 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 GYFGCQVNESTEYLQLFNLSKLCDGTQDCFLGADELSKELKCTNDCDKDGTKCTHGACLNG---- 112
            |...||:...    :|.|..::......|..|.:.::...:..::| ..|.:|.||.|.|.    
Human   320 GVHDCQLCSE----RLGNSERVSAPDGPCPTGFERVNGSCEDVDEC-ATGGRCQHGECANTRGGY 379

  Fly   113 VCHCNDGY-------------------GGCNCVDKD--------ENECKQRPCDVFAHCTNT--- 147
            .|.|.||:                   |.|..|.:|        .|..||..|     |:..   
Human   380 TCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICC-----CSRVGKA 439

  Fly   148 --LGSFTCTCF--PGYR-----GNGFHCEDID--------------------------------- 170
              .|...|..|  .|:|     |.|:|....|                                 
Human   440 WGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 504

  Fly   171 --------------------ECQDPAIAA--------------RCVENAE------CCNLPAHFL 195
                                |...|:|.|              .|..|.:      |.:.|:.:.
Human   505 LPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYT 569

  Fly   196 CKCKDGYEGDGE-VLCTDVDECRN-PENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQDVDE 258
            |.|..|:....: ..|.||||||. |..|.|.. |.|:||::.|.|..|:.. .|....|.||||
Human   570 CACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCVCGPGFRA-GPRAAECLDVDE 632

  Fly   259 C-SYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECARTP--CGRNADCLNTDGSF 320
            | ..|..|..|. |.|..||:.|.||.||.......| |.|.|||.::|  |||.| |.|..|||
Human   633 CHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGAS-CQDVDECTQSPGLCGRGA-CKNLPGSF 694

  Fly   321 RCLCPDGYSGDPMNGC-EDVDECATN-NPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQP 383
            ||:||.|:.|   :.| |||||||.. .|||.| .|.|..|||.|.||:||              
Human   695 RCVCPAGFRG---SACEEDVDECAQEPPPCGPG-RCDNTAGSFHCACPAGF-------------- 741

  Fly   384 LNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQ 448
                               |:.|.|..|.|:|||.:  ....| |..:|.|..||::|:||.|||
Human   742 -------------------RSRGPGAPCQDVDECAR--SPPPC-TYGRCENTEGSFQCVCPMGFQ 784

  Fly   449 -GQGYLHCENINECQDNPCGENAICTDTVGSFVC-TCKPDYTGDPFRG-CVDIDECTALDKPCGQ 510
             ......||:::||:::.......|.::.|||.| ||...:  ...|| |.|:|||::...|||.
Human   785 PNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGH--HLHRGRCTDVDECSSGAPPCGP 847

  Fly   511 HAVCENTVPGYNCKCPQGY---DGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFE 572
            |..|.||...:.|.|..||   .|:|.|                                     
Human   848 HGHCTNTEGSFRCSCAPGYRAPSGRPGP------------------------------------- 875

  Fly   573 PIGSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCEDVRCGAHAYCK 637
                 |.|::|| ...:.|.||.:||||.||:.|.|..|                          
Human   876 -----CADVNEC-LEGDFCFPHGECLNTDGSFACTCAPG-------------------------- 908

  Fly   638 PDQNEAYCVCEDGWTYNPSDVAAGCVDIDEC---DVMHGPFGSCGQNATCTNSAGGFTCACPPGF 699
                           |.|....|.|:|:|||   |:       | |:..|||:.|.|.|.||||.
Human   909 ---------------YRPGPRGASCLDVDECSEEDL-------C-QSGICTNTDGSFECICPPGH 950

  Fly   700 SGDPH-SKCVDVDECR-TGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANE 762
            ...|. :.|:|||||| .|.:.||: ..|.|.| |.|.|      :.|.||.....|..:|...:
Human   951 RAGPDLASCLDVDECRERGPALCGS-QRCENSP-GSYRC------VRDCDPGYHAGPEGTCDDVD 1007

  Fly   763 DCP--GNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAG 825
            :|.  |..||.|.:                ||  |.....:|..|       |.|||  .....|
Human  1008 ECQEYGPEICGAQR----------------CE--NTPGSYRCTPA-------CDPGY--QPTPGG 1045

  Fly   826 GCNDIDECRANP-CAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCV 889
            ||.|:||||... |...|:|.|..|.:                                      
Human  1046 GCQDVDECRNRSFCGAHAVCQNLPGSF-------------------------------------- 1072

  Fly   890 QDSYTGNSVCICRQGYERNSENGQCQDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNP 954
                    .|:|.||||...:...|.||:||...:|  .||. |||:|:.||:.|.||       
Human  1073 --------QCLCDQGYEGARDGRHCVDVNECETLQG--VCGA-ALCENVEGSFLCVCP------- 1119

  Fly   955 FIMCEICNTPE------CQCQSPYKLVGN----------SCVL---------------------- 981
                   |:||      .:|..|....|.          |.||                      
Human  1120 -------NSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVG 1177

  Fly   982 SG---CSSGQACPSGAE------------CISIAGG------VSYC----------ACP--KGYQ 1013
            ||   |....|.|...:            |.::..|      :..|          .||  :|| 
Human  1178 SGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY- 1241

  Fly  1014 TQPDGSCV---DVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRKCAADR 1075
            ..|.|...   |||||:....|:|..|. |||....|||:|..||.   |:     .||      
Human  1242 LAPSGDLSLRRDVDECQLFRDQVCKSGV-CVNTAPGYSCYCSNGYY---YH-----TQR------ 1291

  Fly  1076 ECAANEKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPSDPPQCMCEAGFKGDPLL 1140
                                                                            |
Human  1292 ----------------------------------------------------------------L 1292

  Fly  1141 GCTDEDECS-HLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDCA--S 1202
            .|.|.|||: ..|...|..|||..|.|.|.|......|          |:.: :|:||:..:  .
Human  1293 ECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLD----------GSQR-RCVSNESQSLDD 1346

  Fly  1203 NLACLEGSCVSPC-SSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDC-VSQCQD-----VICG- 1259
            ||    |.|.... :.|:|   ::...::.|.:..|...|.:....|| :...||     .:|. 
Human  1347 NL----GVCWQEVGADLVC---SHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNV 1404

  Fly  1260 ----------DGALCIPTSEGPTCKCPQGQLGNPFPGGSCSTDQCSAARPCGERQICINGRCKER 1314
                      .|...:|...||       .||.|:.|           .|.|             
Human  1405 LRPPAYSPPRPGGFGLPYEYGP-------DLGPPYQG-----------LPYG------------- 1438

  Fly  1315 CEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMP--PIEQAKCSPGCGENAHCEYG-------- 1369
                                        |:|...|  |.:.....||........||        
Human  1439 ----------------------------PELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPD 1475

  Fly  1370 -------LGQSRCACNPG--------------TF--------GNPYEGCGAQSKNVCQPNSCG-- 1403
                   .|:|.....||              :|        |..|.|..|:.....:...||  
Human  1476 FEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGIL 1540

  Fly  1404 ---PNAECRAVGNHISCLCPQGFS-GNPYIGCQDVDEC----ANKPCGLNAACLNRAGGFECLCL 1460
               .|..|..|....:|.|..|:. ....:.|.|::||    |..|..:||.|||..|.|.|:|.
Human  1541 DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR 1605

  Fly  1461 SGHA--GNPYSSCQP 1473
            .|.|  ..|: .|.|
Human  1606 PGFAPTHQPH-HCAP 1619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 9/40 (23%)
EGF_CA 212..247 CDD:238011 16/35 (46%)
EGF_CA 255..>286 CDD:214542 15/31 (48%)
EGF_CA 298..331 CDD:238011 19/34 (56%)
EGF_CA 338..373 CDD:238011 20/35 (57%)
EGF_CA 413..456 CDD:238011 16/43 (37%)
EGF_CA 457..490 CDD:238011 9/33 (27%)
EGF_CA 497..>529 CDD:214542 13/31 (42%)
EGF_CA 580..>612 CDD:214542 14/31 (45%)
EGF_3 676..702 CDD:289699 12/25 (48%)
EGF_CA 1022..1056 CDD:214542 16/33 (48%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
LTBP4NP_001036009.1 cEGF 567..590 CDD:289433 6/22 (27%)
EGF_CA 587..623 CDD:214542 16/37 (43%)
EGF_CA 629..670 CDD:214542 18/42 (43%)
EGF_CA 671..708 CDD:238011 20/40 (50%)
EGF_CA 710..744 CDD:214542 21/67 (31%)
EGF_CA 752..792 CDD:284955 16/42 (38%)
EGF_CA 834..867 CDD:214542 14/32 (44%)
EGF_CA 878..914 CDD:214542 17/77 (22%)
EGF_CA 920..955 CDD:214542 17/42 (40%)
EGF_CA 961..999 CDD:214542 18/45 (40%)
EGF_CA 1005..1048 CDD:214542 16/69 (23%)
EGF_CA 1049..1090 CDD:214542 16/86 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1130..1179 6/48 (13%)
TB 1193..1230 CDD:279073 3/36 (8%)
EGF_CA 1296..>1325 CDD:238011 13/28 (46%)
TB 1361..1397 CDD:279073 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1446..1524 12/77 (16%)
EGF_CA 1574..>1608 CDD:214542 14/33 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..146
EGF_CA 357..>387 CDD:214542 10/30 (33%)
TB 418..453 CDD:279073 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 474..546 4/71 (6%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11667
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41397
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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