DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and HMCN1

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_114141.2 Gene:HMCN1 / 83872 HGNCID:19194 Length:5635 Species:Homo sapiens


Alignment Length:1123 Identity:252/1123 - (22%)
Similarity:342/1123 - (30%) Gaps:474/1123 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 SKLCDGTQDCFLGA--DELSKELKCTND--CDKDGTKCTHG-------ACLNGVCH----CND-- 118
            ::||:.....|.|:  |....:::..|:  |...|...|..       :|..|...    |:|  
Human  4667 ARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV 4731

  Fly   119 -GYGGCNCVDKD--ENECKQRPCDVFAHCTNTLGSFTC--TCFPGYRGNGFHCEDIDECQDP--- 175
             .|||..|...|  .:.|...||....:.:...|..||  ||      ||........|.:|   
Human  4732 PQYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTC------NGGQMRRYRTCDNPPPS 4790

  Fly   176 ----------AIAARCVENAECCNLPA-----HFLCKCK---DGYEGDGEVLC------------ 210
                      :...||  |.:.|.:..     |...:|.   .|.|...:.||            
Human  4791 NGGRACGGPDSQIQRC--NTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPC 4853

  Fly   211 ----TDVDECRNPENC--GP---------------------NALCTNTPGNYT-------CSCPD 241
                |.|..| |.:.|  ||                     ||..|::|.:.|       .:.|.
Human  4854 PGDTTQVTRC-NVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPR 4917

  Fly   242 GYVGN---------NP-YREGCQDVDECSYPNVCGPGAICTN----------------LEGSYRC 280
            . :|:         || |....:::.|..      .|...||                |:.|:  
Human  4918 S-LGSAMRKIVSILNPIYWTTAKEIGEAV------NGFTLTNAVFKRETQVEFATGEILQMSH-- 4973

  Fly   281 DCPPGYDGDGR-----SESGCVDQ-------------DECARTPCGR------------------ 309
             ...|.|.||.     ..||.|.|             ::..:|..|:                  
Human  4974 -IARGLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPY 5037

  Fly   310 ----------------------NADCLNTD------------------GSFRCLCPDGYSGDPMN 334
                                  :|..:.:|                  |.....||.|::.|.:.
Human  5038 TWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGFTLDSVG 5102

  Fly   335 G-CEDVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDI 398
            . |.|.||||..|||  ...|.|..|::.|.||.|..:..|                        
Human  5103 PFCADEDECAAGNPC--SHSCHNAMGTYYCSCPKGLTIAAD------------------------ 5141

  Fly   399 APYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCL--CPSGFQ--GQGYLHCENIN 459
                     |..|.|||||..  |...|.....|.|..|||||:  |.|||:  ..| |.|::||
Human  5142 ---------GRTCQDIDECAL--GRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDG-LSCQDIN 5194

  Fly   460 ECQD-NPCGENAICTDTVGSFVCTCKPDY--TGDPFRGCVDIDECTALDKPCGQHAVCENTVPGY 521
            |||: :||.:.  |.:.:|||.|.|:|.|  .|   |.|:|::||.  ...|.....|:||..||
Human  5195 ECQESSPCHQR--CFNAIGSFHCGCEPGYQLKG---RKCMDVNECR--QNVCRPDQHCKNTRGGY 5252

  Fly   522 NCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDECRT 586
            .|                  :|:         |.|.....||            .:|:|||||:.
Human  5253 KC------------------IDL---------CPNGMTKAEN------------GTCIDIDECKD 5278

  Fly   587 HAEVCGPHAQCLNTPGSYGCECEAGY----VGSPPRMACKQPCEDVRCGAHAYCKPDQNEAYCVC 647
            ....|..:..|.||.|||.|.|..||    ||.|                               
Human  5279 GTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRP------------------------------- 5312

  Fly   648 EDGWTYNPSDVAAGCVDIDECDVMHGPFGSCGQNATCTNSAGGFTCACPPGFSGDPHSKCVDVDE 712
                          |:||:||:.:..|   |...  |:|:.|.|.|.||||             :
Human  5313 --------------CMDINECEQVPKP---CAHQ--CSNTPGSFKCICPPG-------------Q 5345

  Fly   713 CRTGASKCGAGAECVNVPGGGYTCR-----CPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDA 772
            ...|..|..||.|.:...|..|:..     .|......|....|....:..|.:|.....:....
Human  5346 HLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSR 5410

  Fly   773 TKRCL---CPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGCNDIDEC- 833
            |:|.:   |||   |::..|..                                   |.||||| 
Human  5411 TRRTIRKTCPE---GSEASHDT-----------------------------------CVDIDECE 5437

  Fly   834 RANPCAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQDSYTGNSV 898
            ..:.|..:  |.||.|.|.|.||                                          
Human  5438 NTDACQHE--CKNTFGSYQCICP------------------------------------------ 5458

  Fly   899 CICRQGYERNSENGQCQDVDECSVQRGKPACGLNALCKNLPGSYEC---RCPQGHNGNPFIMCEI 960
                .||:.......|||:|||..|  ...||.|.:|.|:.|||:|   .||..:..:|.....:
Human  5459 ----PGYQLTHNGKTCQDIDECLEQ--NVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCL 5517

  Fly   961 CNTP----ECQCQSPYKL 974
            .|.|    || ..|||.|
Human  5518 KNCPPNDLEC-ALSPYAL 5534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 9/30 (30%)
EGF_CA 212..247 CDD:238011 13/73 (18%)
EGF_CA 255..>286 CDD:214542 6/46 (13%)
EGF_CA 298..331 CDD:238011 9/103 (9%)
EGF_CA 338..373 CDD:238011 15/34 (44%)
EGF_CA 413..456 CDD:238011 20/46 (43%)
EGF_CA 457..490 CDD:238011 15/35 (43%)
EGF_CA 497..>529 CDD:214542 10/31 (32%)
EGF_CA 580..>612 CDD:214542 14/31 (45%)
EGF_3 676..702 CDD:289699 10/25 (40%)
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
HMCN1NP_114141.2 VWA_2 42..212 CDD:290253
IG_like 440..512 CDD:214653
Ig 451..510 CDD:299845
IG 526..608 CDD:214652
IGc2 533..593 CDD:197706
I-set 612..696 CDD:254352
Ig 626..696 CDD:299845
IG 708..789 CDD:214652
Ig 720..786 CDD:143165
Ig 792..884 CDD:299845
I-set 793..884 CDD:254352
I-set 890..977 CDD:254352
IGc2 903..967 CDD:197706
Ig 980..1071 CDD:299845
IG 1086..1167 CDD:214652
Ig 1086..1167 CDD:299845
I-set 1171..1258 CDD:254352
Ig 1188..1256 CDD:299845
Ig 1261..1357 CDD:299845
IG_like 1276..1355 CDD:214653
IG_like 1369..1448 CDD:214653
IGc2 1382..1438 CDD:197706
I-set 1452..1542 CDD:254352
Ig 1460..1542 CDD:299845
IG 1556..1635 CDD:214652
Ig 1557..1635 CDD:299845
I-set 1647..1729 CDD:254352
Ig 1648..1725 CDD:299845
IGc2 1752..1812 CDD:197706
IG_like 1843..1915 CDD:214653
IGc2 1843..1905 CDD:197706
IG 1929..2008 CDD:214652
Ig 1934..2008 CDD:299845
Ig 2031..2092 CDD:299845
I-set 2111..2191 CDD:254352
IGc2 2119..2181 CDD:197706
I-set 2203..2286 CDD:254352
Ig <2222..2277 CDD:299845
IG_like 2299..2380 CDD:214653
Ig 2299..2370 CDD:299845
I-set 2391..2474 CDD:254352
IGc2 2400..2464 CDD:197706
I-set 2478..2567 CDD:254352
IGc2 2493..2557 CDD:197706
I-set 2582..2663 CDD:254352
IGc2 2594..2653 CDD:197706
I-set 2681..2762 CDD:254352
IGc2 2689..2752 CDD:197706
IG_like 2789..2865 CDD:214653
IGc2 2791..2855 CDD:197706
I-set 2879..2960 CDD:254352
Ig 2879..2950 CDD:299845
Ig 2963..3054 CDD:299845
I-set 2970..3052 CDD:254352
I-set 3066..3147 CDD:254352
IGc2 3073..3137 CDD:197706
I-set 3151..3241 CDD:254352
IGc2 3167..3228 CDD:197706
Ig 3244..3338 CDD:299845
I-set 3252..3336 CDD:254352
I-set 3356..3430 CDD:254352
IGc2 3357..3420 CDD:197706
Ig 3433..3523 CDD:299845
IG_like 3443..3523 CDD:214653
IG_like 3536..3616 CDD:214653
IGc2 3543..3606 CDD:197706
I-set 3628..3709 CDD:254352
IGc2 3636..3699 CDD:197706
I-set 3719..3800 CDD:254352
Ig 3719..3795 CDD:299845
I-set 3804..3893 CDD:254352
Ig 3810..3883 CDD:299845
Ig 3896..3984 CDD:299845
IG_like 3903..3984 CDD:214653
Ig 3987..4067 CDD:299845
IG 3994..4075 CDD:214652
I-set 4079..4165 CDD:254352
IGc2 4093..4155 CDD:197706
Ig 4168..4258 CDD:299845
IG_like 4176..4256 CDD:214653
I-set 4260..4345 CDD:254352
IGc2 4274..4335 CDD:197706
IG 4356..4435 CDD:214652
Ig 4356..4435 CDD:299845
I-set 4440..4526 CDD:254352
Ig 4443..4521 CDD:299845
TSP1 4533..4584 CDD:214559
TSP1 4589..4641 CDD:214559
TSP1 4646..4698 CDD:214559 6/30 (20%)
TSP1 4703..4755 CDD:214559 12/51 (24%)
TSP1 4760..4812 CDD:214559 12/59 (20%)
TSP1 4817..4869 CDD:214559 10/52 (19%)
G2F 4868..5092 CDD:214774 32/233 (14%)
EGF_CA 5107..5146 CDD:214542 17/73 (23%)
EGF_CA 5147..5190 CDD:284955 20/45 (44%)
EGF_CA 5192..5228 CDD:214542 17/40 (43%)
EGF_CA 5230..5263 CDD:238011 13/61 (21%)
EGF_CA 5272..5313 CDD:284955 19/85 (22%)
EGF_CA 5315..5354 CDD:214542 17/56 (30%)
EGF_CA 5432..5471 CDD:214542 16/86 (19%)
EGF_CA 5472..5508 CDD:214542 16/37 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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