DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and si:dkey-33c9.6

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_021327566.1	Gene:	si:dkey-33c9.6 / 795086	ZFINID:	ZDB-GENE-130530-592	Length:	829	Species:	Danio rerio

Alignment Length:	368	Identity:	71/368 - (19%)
Similarity:	125/368 - (33%)	Gaps:	107/368 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly 22367 CVNPCNATQPCG-----VNAFCSVRDTLPVRTMICECLEGYTGNPAVQC-DKR------SLCVI- 22418
            ||....:.|.||     |.:.|.::.  |....:|..::|:      :| |:|      :.||.
Zfish   482 CVQSNESAQICGSLYVMVQSACGLQH--PSSAYVCVEVDGF------ECYDRRKQTSLSAFCVTP 538

  Fly 22419 --EKGFVRDVDGQCVCPPGTALDIYEYCTPCREEQGFRIDESGHCVCALERGMVIDERGRCTC-- 22479
              ::..|..|||        |..:: ....|:.|...:.|..|..|..|:...:..:..:.||
Zfish   539 QWDEELVFIVDG--------AKQLF-LVFVCQYENDTQNDIVGRTVLNLDPDNMFKKWKKVTCSL 594

  Fly 22480 ---PIDLGYRLTPRGECQPEEPPE----------CTSNDQCADN---------RFC--NLDTKTC 22520
               .:.|..:..|    .|.|||.          |....|.|..         |.|  .::.:..
Zfish   595 GHVDVTLSLKYVP----HPLEPPSTTPILQEPVFCVPIGQVAMQESVLVPHIVRSCVEEVERRGL 655

  Fly 22521 EDPCLTKVCGVNAFCNAV------NHRAQCQCITGYTGN---------------PDLHCNHTNFR 22564
            ::..:.::.|.:....|:      |:|.....:.....|               |.:.|.|.:..
Zfish   656 KEEGIYRISGASTEIQALKYAFNTNYREAVSKLRSVDVNAVSGTLKLYFRELPLPLIPCEHFSEL 720

  Fly 22565 TD-------FPRPDMVVSCLADGVQVEIHITEPGFNGVLYVKGH------SKDEECRRVVNLA-- 22614
            :|       |.|.|.::|.|..       :.:...|.:|::..|      .|:|....:.|||
Zfish   721 SDALDIADPFVRADSLLSLLQS-------LPDVNRNTLLFLLHHLRRVAERKEENKMSLSNLATV 778

  Fly 22615 -GETVPRTEIFRVHFGSCGMQAVKDVASFVLVIQKHPKLVTYK 22656
             |.::.|..:.||.. |..::....|....|..|..|:.:..|
Zfish   779 FGPSLLRPPVSRVDI-SQEVEVQVQVIFLYLQFQNLPEALLTK 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	19/90 (21%)
		Zona_pellucida	<22714..22810	CDD:278526
si:dkey-33c9.6	XP_021327566.1	RhoGEF	71..281	CDD:214619
		PH-like	297..453	CDD:327399
		C2	495..605	CDD:326325	24/126 (19%)
		RhoGAP	624..812	CDD:295372	34/195 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910