DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and notch1b

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_005168706.1 Gene:notch1b / 794892 ZFINID:ZDB-GENE-990415-183 Length:2482 Species:Danio rerio


Alignment Length:2170 Identity:539/2170 - (24%)
Similarity:714/2170 - (32%) Gaps:806/2170 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 LGADELSKELKCTNDCDKDGT--------------------------KCTHGACLNG-------- 112
            :..:.|::.|:|:..|...||                          .|....|.||        
Zfish    12 ISLNTLTQGLECSEKCQNGGTCEPTADGRGECKCLDLYAGPACQFRNPCFQSPCRNGGVCRLITS 76

  Fly   113 ------VCHCNDGYGGCNCVDKDENECKQRPCDVFAHCTNT-LGSFTCTCFPGYRGNGFHCEDID 170
                  ||:|:.||....|:....|.|...||.....|..| :.::.|.|.||:.|.        
Zfish    77 ANKVDFVCNCSLGYTDRLCLTPTNNVCLGAPCRNGGTCELTSIHNYRCKCPPGWSGK-------- 133

  Fly   171 ECQ--DPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDECRN-PENCGPNALCTNTP 232
            .||  ||..:..|....:|....:.|||.|...:  .|:....||:||.. |..|....:|.|..
Zfish   134 TCQQADPCASNPCANGGQCSPFDSDFLCHCTPYF--SGQTCKQDVNECAQIPSPCKNGGVCENGV 196

  Fly   233 GNYTCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNL-EGSYRCDCPPGYDG-------- 288
            |.|.|:||..|.|.:     |:.:.:...|:.|..|..|... |.||.|.|.||:.|        
Zfish   197 GTYHCNCPAEYTGKH-----CESLYQPCNPSPCLHGGTCVQKGETSYECSCLPGFSGQNCEENID 256

  Fly   289 ---DGRSESG--CV---------------------DQDECARTP--CGRNADCLNTDGSFRCLCP 325
               |.|..:|  ||                     |.:||...|  |.....||||.|.:.|:|.
Zfish   257 DCPDHRCLNGGTCVDGVNTYNCQCKPEWTGQFCTEDVNECDLMPNSCQNGGTCLNTQGGYNCVCV 321

  Fly   326 DGYSGDPMNGCEDVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLG 390
            :|::||..:  |::|:|| :..|..||.|.:...||.|.||.|                      
Zfish   322 NGWTGDDCS--ENIDDCA-DAACHTGATCHDRVASFLCECPHG---------------------- 361

  Fly   391 YGPGATDIAPYQRTSGAGLACLDIDEC--NQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYL 453
                        ||   ||.|...|.|  |.....:.|.||.  :|  |...|.||.|:.|..  
Zfish   362 ------------RT---GLLCHLDDACISNPCQKGSNCDTNP--VN--GKAICTCPLGYVGPA-- 405

  Fly   454 HC-ENINECQ--DNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCE 515
             | ::::||.  .|||.....|.:|.|||.|.|...|.|  .|..:||:||  |..||...|.|.
Zfish   406 -CDQDVDECSLGANPCEHAGKCINTKGSFQCKCLQGYVG--ARCELDINEC--LSTPCQNDATCL 465

  Fly   516 NTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFD------CTNNAECIEN----QCFCLDG 570
            :.:.|::|.|..||:|              :.|..|.|      |.||.:||:.    ||.|..|
Zfish   466 DQIGGFHCICMPGYEG--------------VFCQINTDECASMPCLNNGKCIDKINNYQCECPTG 516

  Fly   571 FEPIGSSC-VDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCEDVRCGAHA 634
            |.  ||.| .|||||.  :..|...|:|::.|..|.|:|..||.|        |.||        
Zfish   517 FS--GSQCQFDIDECA--STPCKNGAKCMDGPNMYTCQCTEGYTG--------QHCE-------- 561

  Fly   635 YCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDECDVMHGPFGSCGQNATCTNSAGGFTCACPPGF 699
                                        .|:|||  :..|   | ...||.:....|||.|..||
Zfish   562 ----------------------------TDVDEC--LSNP---C-HYGTCKDGLASFTCVCRAGF 592

  Fly   700 SGDPHSKC-VDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSAN-E 762
            .|   ..| ::::||.  :..|..|..|.: ....|.|.||..|..           .:|..| :
Zfish   593 MG---RLCEININECL--SQPCQNGGTCQD-RENAYLCVCPKGTAG-----------ANCEINLD 640

  Fly   763 DCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGC 827
            ||..|                      ||:      ..:|:......:|.|.|||||..     |
Zfish   641 DCQSN----------------------PCD------FGRCIDKINGYECACEPGYTGKM-----C 672

  Fly   828 N-DIDECRANPCAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQD 891
            | :||||..|||.....|.:...|:.|.|..|     |.:....|:...|. :|||..|. | :|
Zfish   673 NINIDECAINPCHNGGTCVDGVNGFTCLCREG-----YHDTTCQSQLNECL-SNPCIHGH-C-ED 729

  Fly   892 SYTGNSVCICRQGYER---NSENGQCQDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNG- 952
            ...|.: |||..|:..   :..|.:|:         ..| |.....||::...|.|.|..|.:| 
Zfish   730 KVNGYN-CICDSGWSGVNCDINNNECE---------SNP-CMNGGTCKDMTSGYVCTCRAGFSGP 783

  Fly   953 -----------NPFIMCEICNTP----ECQCQSPYKLVGNSC--VLSGCSSGQACPSGAECISIA 1000
                       ||.:....|...    :|.|..||  .|.:|  :|:.|.| :.|.:|..|....
Zfish   784 NCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPY--TGENCETLLAPCGS-KPCKNGGVCKESE 845

  Fly  1001 GGVSY-CACPKGYQTQPDGSC-VDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGL 1063
            ...|: |.||.|:|.|   :| ||::||.:..   |...|.|.|..|||.|.|..||.|      
Zfish   846 DYESFSCVCPAGWQGQ---TCEVDINECVKNP---CRNDAICQNSIGSYKCSCKAGYTG------ 898

  Fly  1064 CALAQRKCAAD-RECAANEKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPSDPPQ 1127
                 |.|..| .:|       :|..|          .:...||.....|.|    .|.|     
Zfish   899 -----RNCETDIDDC-------KPNPC----------SNGGFCKDAVNAFAC----TCLP----- 932

  Fly  1128 CMCEAGFKGDPLLGCTDED--ECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTP 1190
                 ||:|    |..:||  ||...||..||.|.:....|.|.||      |..||...|:.||
Zfish   933 -----GFRG----GRCEEDINECESNPCKNGANCTDCVNSYTCTCP------PGFSGIHCENNTP 982

  Fly  1191 KSKCLSNDDCASNLACLEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQD 1255
            .              |.|.||.                                           
Zfish   983 D--------------CTESSCF------------------------------------------- 990

  Fly  1256 VICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSCSTDQCSAARPCGERQICINGRCKERCEGVVC 1320
                :|..|:......||.||:|     |.|..|..|              ||     .|:...|
Zfish   991 ----NGGTCVDGINSFTCLCPKG-----FTGNYCQHD--------------IN-----ECDSRPC 1027

  Fly  1321 GIGATCDRNNG--KCICEPNFVGNPDLICMPPIEQAKCSPGCGENAHCEYGLGQSRCACNPGTFG 1383
            ..|.||..:.|  ||.|...:.|   |.|...:...|.|| |.....|.....:..|.|..|..|
Zfish  1028 MNGGTCQDSYGTYKCTCPQGYHG---LNCQELVNWCKPSP-CKNGGICRQSGTRYSCQCQTGWTG 1088

  Fly  1384 ----NPYEGC--GAQSKNVCQPNSCGPNAECRAVGNHISCLCPQGFSGNPYIGCQD-VDECANKP 1441
                .|...|  .|:.:.|.....|..:.:|...||...|.|..|::|: |  |:: ||||...|
Zfish  1089 LYCDVPSVSCEVAAKQQGVDVVRLCRNSGQCLDAGNTHYCHCQAGYTGS-Y--CEEQVDECIPNP 1150

  Fly  1442 CGLNAACLNRAGGFECLCLSGHAG-NPYSSCQPIESKFCQDANKCQCNERVECPEGYSCQK-GQC 1504
            |...|.|.:..||:.|.|:.|:.| |            |.|    :.||.:..|    ||. |.|
Zfish  1151 CQNGATCTDYLGGYSCECVPGYHGVN------------CSD----EINECLSQP----CQNGGTC 1195

  Fly  1505 KNLCSQASCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCGNDADC-------LHSEICFQL 1562
            .:|.:...|.           ||.|..|     || |.|     |..||       .|...||..
Zfish  1196 IDLINTYKCS-----------CPRGTQG-----VH-CEI-----NIDDCTPFTDPITHEPKCFNQ 1238

  Fly  1563 GKGLRKCVDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEEEDKCKSDQ 1627
            |    :|||.            |...|   |||..|:.|                   ::|:.| 
Zfish  1239 G----RCVDR------------VGGYH---CICPPGYVG-------------------ERCEGD- 1264

  Fly  1628 DCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAG-HAICNCAESYVWNPVVSSCEKPSLP 1691
                          :.||::               ||.| |:                       
Zfish  1265 --------------VNECLS---------------NPCGTHS----------------------- 1277

  Fly  1692 DCTSDANCPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRCDCLNGFVGNPNDR--NG 1754
                                                  |:..::..||:|..|:.|...|:  :|
Zfish  1278 --------------------------------------CIQLKNNYRCECRTGYTGQHCDKVFDG 1304

  Fly  1755 CQPAQKHHCRNHAECQESEACIKDESTQTLGCRPACDTVKCGPRAVCVTNNHQAQCQCPPGPFAG 1819
            |:...   |||...|                             ||.....|...|:|||| |.|
Zfish  1305 CKGKP---CRNGGTC-----------------------------AVASNTPHGFICKCPPG-FTG 1336

  Fly  1820 DPYDPFNGCQSVPCVYNHDCPPSQMCNRMTHTCFDVCDEESCGDNAICLAEDHRAVCQCPPGFKG 1884
            .           .|.|:            .|.|..:    .|.:...|::......|.|.|.|.|
Zfish  1337 S-----------TCEYD------------AHACGSL----QCKNGGTCVSGHKSPKCLCTPAFTG 1374

  Fly  1885 DPLPEVACTKQGGCAAGTCHPSAICEVTPEGPV--CKCPPLFVG------D-AKSGGCRPD-GQC 1939
               ||......|.|....|:....||...|.|.  |.||..|.|      | :..||...| ...
Zfish  1375 ---PECQDPSGGHCTTNPCYNGGTCEYITEEPYYHCICPTNFNGLFCHILDWSFPGGTGQDITPA 1436

  Fly  1940 PNGDADCPANTICAGGVCQNPCDNACGSNAECKVINRKPVC-----SCPLRFQPISDTAKDGCAR 1999
            |.....|.... |........||:||.:.|          |     .|.|.|   :|..|     
Zfish  1437 PKVSVSCEIEQ-CKVKKGNKICDSACNNYA----------CDWDGGDCSLNF---NDPWK----- 1482

  Fly  2000 TISKCLTDVDCGGAL-CY----NGQCRIACRNSQDCSDGESCLKNVCVVA---------CLDHSQ 2050
                     :|..|| |:    ||:|...|.|:....||..|.:   |.|         |.||  
Zfish  1483 ---------NCSAALQCWRYFNNGKCDEQCHNTGCLYDGFDCQR---VEAQCNPLYDQYCKDH-- 1533

  Fly  2051 CASGLACVEGHCTIGCRSNKECKQD 2075
                  ..:|:|..|| :|.||:.|
Zfish  1534 ------FADGYCDQGC-NNAECEWD 1551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 9/29 (31%)
EGF_CA 212..247 CDD:238011 15/35 (43%)
EGF_CA 255..>286 CDD:214542 10/31 (32%)
EGF_CA 298..331 CDD:238011 13/34 (38%)
EGF_CA 338..373 CDD:238011 13/34 (38%)
EGF_CA 413..456 CDD:238011 14/45 (31%)
EGF_CA 457..490 CDD:238011 13/34 (38%)
EGF_CA 497..>529 CDD:214542 12/31 (39%)
EGF_CA 580..>612 CDD:214542 12/31 (39%)
EGF_3 676..702 CDD:289699 9/25 (36%)
EGF_CA 1022..1056 CDD:214542 13/33 (39%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
notch1bXP_005168706.1 EGF_CA 175..213 CDD:238011 15/42 (36%)
EGF_CA 221..252 CDD:238011 12/30 (40%)
EGF_CA 254..290 CDD:238011 5/35 (14%)
EGF_CA 292..329 CDD:238011 15/36 (42%)
EGF_CA 332..367 CDD:238011 17/72 (24%)
EGF_CA 409..447 CDD:238011 15/39 (38%)
EGF_CA 449..485 CDD:238011 15/51 (29%)
EGF_CA 487..523 CDD:238011 14/37 (38%)
EGF_CA 525..561 CDD:238011 16/45 (36%)
EGF_CA 563..598 CDD:238011 15/43 (35%)
EGF_CA 600..636 CDD:238011 10/49 (20%)
EGF_CA 638..672 CDD:238011 14/66 (21%)
EGF_CA 675..711 CDD:238011 13/40 (33%)
EGF_CA 715..747 CDD:238011 12/35 (34%)
EGF_CA 752..786 CDD:238011 10/43 (23%)
EGF_CA 788..824 CDD:238011 8/37 (22%)
EGF_CA 866..902 CDD:238011 16/49 (33%)
EGF_CA 904..940 CDD:238011 14/70 (20%)
EGF_CA 942..978 CDD:238011 15/41 (37%)
EGF_CA 985..1016 CDD:238011 12/82 (15%)
EGF_CA 1018..1054 CDD:238011 14/57 (25%)
EGF 1060..1090 CDD:278437 9/30 (30%)
EGF_CA 1143..1177 CDD:238011 15/45 (33%)
EGF_CA 1181..1216 CDD:238011 15/55 (27%)
EGF_CA 1218..1262 CDD:238011 17/81 (21%)
EGF_CA 1264..1298 CDD:238011 13/124 (10%)
EGF_CA <1309..1340 CDD:238011 14/74 (19%)
NL 1437..1473 CDD:197463 9/46 (20%)
Notch 1481..1516 CDD:278494 12/48 (25%)
NL 1515..1555 CDD:197463 14/49 (29%)
NOD 1561..1612 CDD:284282
NODP 1667..1724 CDD:284987
Ank_2 <1867..1953 CDD:289560
ANK repeat 1874..1920 CDD:293786
ANK 1917..2029 CDD:238125
ANK repeat 1922..1953 CDD:293786
Ank_2 1927..2020 CDD:289560
ANK repeat 1955..1986 CDD:293786
ANK 1984..2108 CDD:238125
ANK repeat 1989..2053 CDD:293786
Ank_2 1994..2086 CDD:289560
ANK repeat 2055..2086 CDD:293786
DUF3454 2404..2467 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11856
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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