DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and si:dkey-225n22.4

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_017209369.1	Gene:	si:dkey-225n22.4 / 792513	ZFINID:	ZDB-GENE-120709-30	Length:	957	Species:	Danio rerio

Alignment Length:	760	Identity:	146/760 - (19%)
Similarity:	197/760 - (25%)	Gaps:	300/760 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly 19149 PAPPVKQRPVF----------------VPSPVH-------PTPAPQPGVVNIPSVAQPVHPTYQP 19190
            |..||.  |:|                ||:.:.       |..:.:.....|.||.....|..:.
Zfish   376 PLDPVV--PIFINGKTQISKRSGSDASVPTEIQKLRLYCDPQQSERETACEIYSVDDERCPLDRE 438

  Fly 19191 PVVERPAIYDVYYPPPPSRPGVINIPSPP----------RPVYPVPQQPIYVPAPVLHIPAPRPV 19245
            |..|.....|...|.||..||      ||          |...|.|...   |.|    |..|
Zfish   439 PTFEEECDCDETQPGPPGPPG------PPGARGFRGEKGREGPPGPDGK---PGP----PGLR-- 488

  Fly 19246 IHNIPSVPQPTYPHRNPPIQDVTYPAPQPSPPVPGI------VNIPSLPQP-----VSTPTSGVI 19299
                   .:|.|.....|..||....|:..|.:.|.      ..:|..|.|     .|.|:.|:.
Zfish   489 -------GEPGYVGPPGPKGDVGLSGPRGDPGLQGFKGDQGDQGLPGRPGPPGPMGASKPSIGIA 546

  Fly 19300 NIP---------SQASPPISVPTPGIVNIPSIP-QPTPQRPS-----------PGIINVPSVPQP 19343
            .:|         .:..||   ..||::.:|.|| ...|..|:           ||...
Zfish   547 GLPGEKGAQGGKGEQGPP---GKPGLMGVPGIPGNEGPPGPAGAQGEKGDDGPPGAAG------- 601

  Fly 19344 IPTAPSPGIINIP------------SVPQPLPSPTPGVINIPQQPTPPPLVQQPGIINIPSVQQP 19396
             |..| |||..:.            ..|.|..||.|......|.|:
Zfish   602 -PQGP-PGIRGLSGEAGATGEQGARGAPGPKGSPGPRGAQGAQGPS------------------- 645

  Fly 19397 STPTTQHPIQDVQYETQRPQPTPGVINIPSVSQPTYPTQKPSYQDTSYPTVQPKPPVSGIINIP- 19460
            .||...        ..:.|:.:.|  .......|....||....::.:|..|      |...:|
Zfish   646 GTPGAD--------GARGPKGSAG--ETGGAGAPGAAGQKGQQGESGFPGAQ------GATGLPG 694

  Fly 19461 ----------SVPQPVPSLTPGVINLPSEPSYSAPIPKPGIINVPSIP-EPIPSIPQNPVQEVYH 19514
                      |.|:.... ..|....|..|.::......||......| :|....|.....::.|
Zfish   695 FKGHKGERGESGPRGAQG-EKGTKGFPGLPGFTGETGPRGIKGERGSPGDPGLKGPDGQKGDMGH 758

  Fly 19515 -DTQKPQAIPGVVNVPSAPQPTPGRPYYDVAKPDFEFNPCYPSPCGPYSHCHNRFGVAACVCLPN 19578
             ....|:..||...:|..| ..||.|    .||
Zfish   759 IGVVGPRGFPGQDGLPGQP-GNPGFP----GKP-------------------------------- 786

  Fly 19579 YRGTPPN-------CRPECVINSDCPSSLACINEKCRDPC------PGSCAYNAVCRVHEHVPNC 19630
              |.||:       ||.  |:.:..|..|..::.:..:||      ||          |...|..
Zfish   787 --GKPPSDEYFIKLCRD--VLRNQLPQLLQTMSSQRCEPCETIKGPPG----------HPGAPGP 837

  Fly 19631 YCQTGYTGNP-FISCQRTPIAPVQREPIEAKDPCYPSICGPNAV--CNNGKCSCIPEYRGDPYVG 19692
            ....|..|.| ....|..|..|..:.|        |.:.|...:  ....|....|.|.|.
Zfish   838 KGSIGSPGYPGRHGAQGYPGPPGVQGP--------PGVKGDTGIQGFKGKKGESRPGYPGP---- 890

  Fly 19693 CRPECVLNTDCARDKACIQQKCKNPCPGTCGLQALCHVYNHVATCSCPEGMQGDAFVRCDPKPKP 19757
                                      ||..|:|.             |.|..|..|        |
Zfish   891 --------------------------PGDTGIQG-------------PRGSDGIGF--------P 908

  Fly 19758 QPPAPAPPTTLPAIVPQRAPINPCQPTPCGPNSQCRAYHEQAICY 19802
            .||.....:..|.|..::.|  |.|...|          :.:|||
Zfish   909 GPPGIPGKSGSPGIPGKQGP--PGQAGVC----------DMSICY 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450	30/141 (21%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
si:dkey-225n22.4	XP_017209369.1	vWA_collagen	35..196	CDD:238749
		LamG	242..414	CDD:328935	7/39 (18%)
		Collagen	550..607	CDD:189968	13/68 (19%)
		Collagen	595..654	CDD:189968	16/94 (17%)
		Collagen	628..708	CDD:189968	18/114 (16%)
		Collagen	700..757	CDD:189968	10/57 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910