DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Prx

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_076466.2	Gene:	Prx / 78960	RGDID:	619960	Length:	1383	Species:	Rattus norvegicus

Alignment Length:	893	Identity:	187/893 - (20%)
Similarity:	313/893 - (35%)	Gaps:	230/893 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly 18796 SAPQ-----PIYPTPQSPQYNVNYPSPQPANPQKPG-VVNIPS--VPQPVYPSPQPPVYDVNYPT 18852
            :|||     |..|:.:.....|:.|...|:.....| .:::|:  :..|..|:.:||...:..|.
  Rat   230 TAPQIELVGPRLPSAEVGVPKVSVPKGTPSTEAASGFALHLPTLGLGAPAAPAVEPPTTGIQVPQ 294

  Fly 18853 TPVSQHPGVVNIPSAPRLVPPTSQRPVFITSPGNLSPTPQ-----PG------------VINIPS 18900
            ..:...|.:..:|:.|.|........|.:.:....:|:.:     ||            .:.:|.
  Rat   295 VELPTLPSLPTLPTLPCLDTQEGAAVVKVPTLDVAAPSVEVDLALPGAEVEAQGEVPEVALKMPR 359

  Fly 18901 VSQPGY-----------PTPQSPIYDANYPTTQSPI---------PQQPGV-----VNIPSVPSP 18940
            :|.|.:           ....||...|..|..:.|.         |..|.|     :.:|::..|
  Rat   360 LSFPRFGVRGKEATEAKVVKGSPEAKAKGPRLRMPTFGLSLLESRPSGPEVAAESKLKLPTLKMP 424

  Fly 18941 SY--PAPNPPVNYPTQPSPQIPVQPGVINIPSAPLPTTPP-QHPPVFIPS------PESPSPAPK 18996
            |:  ....|.|..|..|..::|..| .|.:|.||....|. |.|.|.:|.      |:.|..|..
  Rat   425 SFGISVAGPEVKAPKGPEVKLPKVP-EIKLPKAPEAAIPDVQLPEVQLPKMSDMKLPKIPEMAVP 488

  Fly 18997 PGVINIPSVTHPEYPTSQVPVYDVNYSTTPSPIPQKPGVVNIPSAPQPVHPAPNPPVHEFNYPTP 19061
            .  :::|.|..|:.|..:||                  .:.:|..|:...|..:.|..:.
  Rat   489 D--VHLPEVKLPKVPEMKVP------------------EMKLPKIPEMAVPDVHLPDIQL----- 528

  Fly 19062 PAVPQQPGVLNIPSYPTPVAPTPQSP-IYIPSQEQPK-PTTRPSVINVPSVPQPAYPTPQAP--- 19121
            |.||:    :.:|....|..|....| :::|..:.|| |..:...:.:|.||:.|.|..:.|
  Rat   529 PKVPE----MKLPDMKLPKVPEMAVPDVHLPDIQLPKVPEMKLPDMKLPKVPEMAVPDVRIPEVQ 589

  Fly 19122 ---VYDVNYPTSPSV-IPHQPGVVNIPSVPLPAPPVKQRPVFVPS-PVHPTP--------APQPG 19173
               |.:|..|..|.: :|.    |.:|.:.||    |...|.:|. |....|        .|:..
  Rat   590 LPKVSEVKLPKIPDMAVPD----VRLPELQLP----KMSEVKLPKIPDMAVPDVRLPEVQLPKVS 646

  Fly 19174 VVNIPSVAQPVHPTYQPPVVERPAIYDVYYPPPPSRPGVINIPSPPRPVYPVPQQPIYVPAPVLH 19238
            .:.:|.|.:...|..:.|.|:.|.:.|:..|.       |.:|..|....|      .||.|.|.
  Rat   647 ELKLPKVPEMTMPDIRLPEVQLPKVPDIKLPE-------IKLPKVPEMAVP------DVPLPELQ 698

  Fly 19239 IP-APR-PVIHNIPSVPQPTYPHRNPPIQDVTYPAPQPSPPVPGIVNIPSLPQPVSTPTSGVINI 19301
            :| .|: |.:| :|.||:...| :.|..|..:..|.|........    .||: ::.|..|.:..
  Rat   699 LPKVPQVPDVH-LPKVPEMKLP-KVPEAQRKSAGAEQAEKTEFSF----KLPK-MTVPKLGKVTK 756

  Fly 19302 PSQASPPISVPTPGIVNIPSIPQPTPQRPSPGI----INVPSVPQPIPTAPSPGIINIPSVPQPL 19362
            |.:|.  |.||...:: :|.:      :|..|.    :.|||:..|......||.:.:....|..
  Rat   757 PGEAG--IEVPDKLLI-LPCL------QPEVGTEVARVGVPSLSLPSVELDLPGALGLEGQVQEA 812

  Fly 19363 PSPTPGVINIPQQPTPPPLVQQPGIINIPSVQ--QPSTPTTQHPIQDVQYETQRPQPT------- 19418
            .|   |.:..|:.|.......:.| ..:|||:  .|..||.:...:.::....:.:||
  Rat   813 VS---GKVEKPEGPRVAVGTGEAG-FRVPSVEIVNPQLPTVEVKKEQLEMVEMKVKPTSKFSLPK 873

  Fly 19419 ---------------PG----------VINIPSVSQPTYPTQKPSYQDTSYPTVQPKPPVSGIIN 19458
                           ||          .|::|.....|....|.:.:....|.:.        ::
  Rat   874 FGLSGPKAVKAEVEGPGRATKLKVSKFAISLPRARAGTDADAKGAGEAGLLPALD--------LS 930

  Fly 19459 IP--SVPQPVPSLTPGVINLPSEPSYSA-PIPK---------------------------PGIIN 19493
            ||  |:...:||....|....|:|..|. .:||                           .|.:.
  Rat   931 IPQLSLDAQLPSGKVEVAGAESKPKGSRFALPKFGAKGRDSEADVLVAGEAELEGKGWGWDGKVK 995

  Fly 19494 VPSIPEPIPSIPQNPVQEVYHDTQKP----QAIPGVVNVPSAPQPTPG 19537
            :|.:..|...:.:....|:......|    :||.|.:.:|.....|||
  Rat   996 MPKLKMPSFGLSRGKEAEIQDGRVSPGEKLEAIAGQLKIPEVELVTPG 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883	9/41 (22%)
		Med25_SD1	18795..18955	CDD:288132	40/210 (19%)
		MISS	19026..19258	CDD:292450	59/251 (24%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Prx	NP_076466.2	PDZ	17..98	CDD:214570
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9BXM0	70..84
		46 X 5 AA approximate tandem repeats of [LVMGIE]-[PSM]-[EDKA]-[LIVMA]-[AQKHPRT], that may have a tripeptide spacer of [ALKD]-[IPV]-[KPH]	432..722		84/342 (25%)
		Cornifin	<433..524	CDD:280537	27/111 (24%)
		Cornifin	480..586	CDD:280537	29/134 (22%)
		Cornifin	612..723	CDD:280537	33/129 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910