DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Filip1l

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001035487.2	Gene:	Filip1l / 78749	MGIID:	1925999	Length:	1131	Species:	Mus musculus

Alignment Length:	437	Identity:	96/437 - (21%)
Similarity:	157/437 - (35%)	Gaps:	111/437 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  5507 TRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEFRTTIRVEESTLPSRSA 5571
            |:..|.....|.||.   ||:.....::..:.|...| ||...|.|.::::.|.:|.:.:..:..
Mouse   766 TKELERYRHFSKSLR---PSLNERRISDPQVFSKEVQ-TEAADSEPPDYKSLIPLERAVINGQFY 826

  Fly  5572 DRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTS------ 5630
            :..            .|....|:.|::..|.|       ...|:..|.:.:..:|.:.|
Mouse   827 EEN------------EDQDDDPNEEESVLSFR-------CSQSSSLPMNRKLWIPWMKSKEGHPQ 872

  Fly  5631 ----ETTTNVPIGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTTPSESPE--------- 5682
                :|.:|......|..|...|...|..::.|....::|.....|..||  |||.
Mouse   873 NGKIQTKSNGNFVQPGDLVLSHTPGQPLHIKVTPDHIQNTATLEITSPTT--ESPHSYTSTAVIP 935

  Fly  5683 ---TP----TILPSDSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPI 5740
               ||    |||.:.|.|...|..:|||.                .:||.::..||:.|......
Mouse   936 NCGTPKQRITILQNASITPIKSKSSTESL----------------MNLEQSMSPVTMATFARAQT 984

  Fly  5741 GSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTSPSE--SPETPTTLPSD---FTTRPHSD 5800
            ..:.|.||.:.|.:|.:|....|     .||      ||.:  ||| |..:.:.   |...|
Mouse   985 PESCGSVTPERTMSPIQVLAMTG-----SPS------SPEQGCSPE-PIEISAKHAIFRVSP--- 1034

  Fly  5801 QTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGS-----TGGQVTEQTTSSPSEV 5860
                   |..::..|:.|..:.:|:.|     |.:...::.:||     ..|.:...:.|:|.:.
Mouse  1035 -------DRQSSWQFQRSNSNSSSVIT-----TEDNKIHIHLGSPYMQAVAGPMRPASPSAPLQD 1087

  Fly  5861 RTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTTES 5907
            ..|.||....| :::|::.: |....|||..|     .|...|.|.|
Mouse  1088 NRTQGLTNGAL-NKTTNKVT-SSITITPTATP-----LPRQSQITVS 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572	28/152 (18%)
		DUF4758	5700..5877	CDD:292572	40/186 (22%)
		DUF4696	5756..6396	CDD:292395	37/162 (23%)
		DUF4758	5802..5979	CDD:292572	25/111 (23%)
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Filip1l	NP_001035487.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		CortBP2	64..246	CDD:286770
		Laminin_II	291..>377	CDD:283628
		COG1340	325..598	CDD:224259
		PARM	906..>1128	CDD:293666	65/274 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910