DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and nell1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_031756556.1	Gene:	nell1 / 779470	XenbaseID:	XB-GENE-920228	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	784	Identity:	190/784 - (24%)
Similarity:	259/784 - (33%)	Gaps:	302/784 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FLPLVTWIV----LLLSSAVHSQYSQQPQPFKTNLRANSRFRGEVFYL-----------NLENGY 53
            ||.||..|:    ||........|:.:|:...|:.      |||:...           .:.:|.
Frog   231 FLSLVQGIMDLQELLAKMTAKLNYASKPRISLTSQ------RGELHIFVKPTGMLERLTGVSDGI 289

  Fly    54 FGCQVNESTEYLQLFNLSKLCDGTQDCFL-----------------------GADELSKELKCTN 95
            .|...:.       |.|:.|..|..:..:                       |..||..|.|  :
Frog   290 SGASSSS-------FRLNHLSTGADEETIEGNPTVASLHHIDYPPSEEMGMNGYSELLSEAK--D 345

  Fly    96 DCDKDGTKCTHGA----------------CLNG-VCHCNDGYGGCNCVDKD----ENECKQRPCD 139
            ....:.|||.:|.                |.|| :....|.....||.:.|    ||:|    |.
Frog   346 HRPTEATKCIYGGKVLAEGDRILTKSCRECKNGSLQKLMDPCPPLNCSEADRVLPENQC----CS 406

  Fly   140 VFAHCTNTLGSFTCTCFPGYRGNGFHCEDIDECQDPAIAARCVENAECCNLPAHFLCKCKDGY-- 202
            |              |    ||:.|       |.|   ..||.||:||.|......|:|..|:
Frog   407 V--------------C----RGHNF-------CAD---GHRCGENSECRNHNNKATCECLSGFQP 443

  Fly   203 -EGDGEVLCTDVDEC-RNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQDVDECSY-PNV 264
             :|| ...|.|:||| .....|..|.:|.|.||:|.|.|..||:..:.:  .|.:.|||.. .:.
Frog   444 IQGD-PAYCEDIDECAAKMHYCHANTVCVNLPGSYRCDCVPGYIRVDDF--SCTEHDECGEGESS 505

  Fly   265 CGPGAICTNLEGSYRCDCPPGYDGDGR-----SESGCVDQDECARTPCGRNADCLNTDGSFRCLC 324
            |...|||.|....:.|.|.|||.|:|.     .|.||.....|.              ...:|||
Frog   506 CDENAICANSVRGHSCTCKPGYVGNGTVCRAFCEEGCRYGGTCV--------------APNKCLC 556

  Fly   325 PDGYSGDPMNGCE-DVDECATN-NPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQ 387
            |.|::|   :.|| |:||||.. ..|...:.||||.|.|.|.|.|||   ||
Frog   557 PSGFTG---SHCEKDIDECAEGIIECHNHSRCVNLPGWFHCECRSGF---HD------------- 602

  Fly   388 QLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGY 452
                 .|...|        :|.:|:|||||..  ....|..::.|:|..|.:.||||||
Frog   603 -----NGTYSI--------SGESCVDIDECAL--RTHTCWNDSACVNLEGGFDCLCPSG------ 646

  Fly   453 LHCENINECQDNPCGENAICTDTVGSFVCTCKPDYTGD-PFRG---------CVDIDECTALDKP 507
                                            |..||| |..|         .:..|.|
Frog   647 --------------------------------PSCTGDCPHEGGLKRNGQVWTLKEDRC------ 673

  Fly   508 CGQHAVCENTVPGYNCKCPQGYDGK---PDPKVACEQVDVNILCSSNFDCTNNAECIE------- 562
                :||       :||     |||   ......|:...|::.|....|....::|::
Frog   674 ----SVC-------SCK-----DGKIFCRRTACDCQNPSVDLFCCPECDTRVTSQCLDQTGHKVY 722

  Fly   563 ----------NQCFCLDGFEPIGSSCVDID-----------ECRTHAE-VCGPHAQCLNTPGSYG 605
                      .||.||:|         ::|           |..|.:| .|.||  |::.|
Frog   723 HSGDNWTYSCQQCRCLEG---------EVDCWPLTCPILTCEYTTISEGECCPH--CVDDP---- 772

  Fly   606 CECEAGYVGSP--PRMACKQPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDEC 668
              |.|.  |.|  .|..|:.|....|.|...:.........|.|::|         :.|..:| .
Frog   773 --CIAD--GDPYDIRKTCQDPQGITRLGGSVWTMVGSPCTTCKCKNG---------SVCCSVD-L 823

  Fly   669 DVMH 672
            |.:|
Frog   824 DCLH 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	6/28 (21%)
		EGF_CA	212..247	CDD:238011	15/35 (43%)
		EGF_CA	255..>286	CDD:214542	11/31 (35%)
		EGF_CA	298..331	CDD:238011	6/32 (19%)
		EGF_CA	338..373	CDD:238011	17/35 (49%)
		EGF_CA	413..456	CDD:238011	15/42 (36%)
		EGF_CA	457..490	CDD:238011	2/32 (6%)
		EGF_CA	497..>529	CDD:214542	6/31 (19%)
		EGF_CA	580..>612	CDD:214542	11/43 (26%)
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
nell1	XP_031756556.1	TSPN	27..211	CDD:214560
		VWC	354..408	CDD:327433	14/71 (20%)
		EGF_CA	453..>485	CDD:214542	13/31 (42%)
		EGF_3	499..534	CDD:403986	13/34 (38%)
		EGF_CA	568..605	CDD:214542	19/57 (33%)
		EGF_CA	615..653	CDD:214542	18/77 (23%)
		VWC	653..705	CDD:327433	14/73 (19%)
		VWC	720..768	CDD:327433	12/58 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000