DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Syvn1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001158181.1	Gene:	Syvn1 / 74126	MGIID:	1921376	Length:	612	Species:	Mus musculus

Alignment Length:	340	Identity:	90/340 - (26%)
Similarity:	116/340 - (34%)	Gaps:	98/340 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly 18907 PTPQSPIYDANYPTTQSPIPQQPGVVNIPSVPSPSYPAPNPPVNYPTQPSPQIPVQPGVINI--P 18969
            ||.:..:..|:.| .|||.|.:|.....|..|.|....|.|| |:|....|..|  ||:..:  |
Mouse   327 PTCRMDVLRASLP-AQSPPPPEPADQGPPPAPHPQPLLPQPP-NFPQGLLPPFP--PGMFPLWPP 387

  Fly 18970 SAPLPTTPPQHPPVFIPSPESPSPAPKPGVINIPS--VTHPEYPTSQVPVYDVNYSTTPSPIPQK 19032
            ..|.|..||  ||   .|.|:.:|.|....::.||  .|.....||           |.:|   .
Mouse   388 MGPFPPVPP--PP---SSGEAAAPPPTSTAVSRPSGAATTTAAGTS-----------TSAP---A 433

  Fly 19033 PGVVNIPSA-PQPVHPAPNPPVHEFNYPTPPAVPQQPGVLNIPSYPTPVAP------TPQSPIYI 19090
            ||.|..|.| |.|..|.| ||......|.|.|.|           |.||.|      ||:....:
Mouse   434 PGSVPGPEAGPAPGFPFP-PPWMGMPLPPPFAFP-----------PMPVPPAGFAGLTPEELRAL 486

  Fly 19091 PSQEQPKPTTR-PSVINVPSVPQPA------YPT------PQAPVYDVNYPTSPSVIPHQPGVVN 19142
            ...|:.....| .|:.|:.::...|      |.|      |..|...|| ||..:.
Mouse   487 EGHERQHLEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSVN-PTEETA--------- 541

  Fly 19143 IPSVPLPAPPVKQRPVFVPSPVHPTPAPQPGVVNIPSVAQPVHPTYQPPVVERPAIYDVYYPPPP 19207
              |..:.|.|      ...:|....|.|.||.              .||:.|...      ||.|
Mouse   542 --STVVSAAP------STSAPSSEAPTPSPGA--------------SPPIPEAEK------PPAP 578

  Fly 19208 SRPGVI-NIPSPPRP 19221
            ...|:: .:|....|
Mouse   579 ESVGIVEELPEDGEP 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132	17/47 (36%)
		MISS	19026..19258	CDD:292450	52/217 (24%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Syvn1	NP_001158181.1	Involved in FAM8A1 interaction. /evidence=ECO:0000250\|UniProtKB:Q86TM6	1..251
		HRD1	10..>333	CDD:227568	2/5 (40%)
		Interaction with SEL1L. /evidence=ECO:0000269\|PubMed:27064360	21..42
		Interaction with p53/TP53. /evidence=ECO:0000269\|PubMed:17170702	236..270
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..375		14/39 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..449		22/74 (30%)
		HAF-H domain, necessary to form higher-order Hrd1 complexes. /evidence=ECO:0000250\|UniProtKB:Q86TM6	474..529		10/54 (19%)
		PRK06975	<476..>582	CDD:235899	29/143 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..612		22/102 (22%)
		PHA03291	<530..>601	CDD:223033	22/102 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910