DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and GGT2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001338233.1	Gene:	GGT2 / 728441	HGNCID:	4251	Length:	574	Species:	Homo sapiens

Alignment Length:	333	Identity:	67/333 - (20%)
Similarity:	102/333 - (30%)	Gaps:	95/333 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3821 QPSISICLRDAGCPASQACRKLKCVDPCEFATCAPNSPCIVEDHKPICKFCPAG-FIADAK---N 3881
            ||||.:..:  |.|..:.           .|....|...::|....:|..||.. |..|.|   .
Human   158 QPSIQLARQ--GFPVGKG-----------LAAVLENKRTVIEQQPVLCPLCPGEVFCRDRKVLRE 209

  Fly  3882 GCQKAKPGGNCTSNTDCSQAHQCGSSGKCIDPCL--TSCAGGVKCV--VSAHRVTICTCP----- 3937
            |.:...|....|......:..|...:|..:...:  ...|||:...  ::.:|..:...|
Human   210 GERLTLPRLADTYEMLAIEGAQAFYNGSLMAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISL 274

  Fly  3938 -----------------ATLTN-----NTDSNCTSTDITVGTTTQRIETTTDFINVKYTVMQLAN 3980
                             |.:.|     |.......|....|.|..||.....|...|.|::.
Human   275 GDAVLYMPSARLSGPVLALILNILKGYNFSRESVETPEQKGLTYHRIVEAFRFAYAKRTLLG--- 336

  Fly  3981 QTEMRTRFTDIEAENETTGPYTTTTESYKTTKQLSSNPETETPTTLPSRPTTRPFTDQTTEFTSE 4045
                ..:|.|:   .|.....|:...:.:...|:|.:             ||.|.:....||
Human   337 ----DPKFVDV---TEVVRNMTSEFFAAQLRSQISDH-------------TTHPISYYKPEF--- 378

  Fly  4046 IPTITPMEGSTPTPSHLETTV--ASITSESTTREVYTIKPFDRSTPTPVSPDTTVPSITFE---T 4105
               .||.:|.|   :||....  .|..|.::|..:|    |.....:|||      .|.|.   |
Human   379 ---YTPDDGGT---AHLSVVAEDGSAVSATSTINLY----FGSKVCSPVS------GILFNNEWT 427

  Fly  4106 TTNIPIGT 4113
            |:.:|..|
Human   428 TSALPAFT 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572	9/29 (31%)
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
GGT2	NP_001338233.1	G_glu_transpept	56..569	CDD:307247	67/333 (20%)
GGT2	NP_001338233.1	Glutamate binding. /evidence=ECO:0000250	456..457
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910