DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Ptk7

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_006524986.1	Gene:	Ptk7 / 71461	MGIID:	1918711	Length:	1088	Species:	Mus musculus

Alignment Length:	510	Identity:	94/510 - (18%)
Similarity:	157/510 - (30%)	Gaps:	193/510 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly 22456 DESGHCVCALERGMVIDERGRCTCPIDLGYRLTPRGECQPEEPPECTSNDQCADNRFCNLDTKTC 22520
            |:|.|.|.:.||.:.:                      :|..|........||.|.|    .:.|
Mouse   190 DQSTHTVSSRERNLTL----------------------RPASPEHSGLYSCCAHNAF----GQAC 228

  Fly 22521 EDPCLTKVCGVNAFCNAV----------NHRAQCQC-------------------ITGYTGNPDL 22556
            .....|......:|...|          |..|...|                   ||..:..|.|
Mouse   229 SSQNFTLSVADESFARVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHL 293

  Fly 22557 H-----CNHTNFRTDF-PRPDMVVSCLADG-------VQVEIHITE-----PGFNGVLYVKGHSK 22603
            .     .|.:...|.. ||...|..|:..|       ::..:|:.|     | |...:::.|
Mouse   294 RRAVVFANGSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLP-FEPRVFIAG--- 354

  Fly 22604 DEECRRVVNLAGETVPRTEIFRVHFG----------SCGMQAVKDVASFVLVIQKHPKLVTYKAQ 22658
            |||  ||...|.:.:|...::..|.|          ..|::.|     ||.:.:....:  |...
Mouse   355 DEE--RVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELV-----FVTIAESDTGV--YTCH 410

  Fly 22659 AYNIKCVYQTGEKNVTLGFNVSMLTT-----------------AGTIANTGPPPIC-----QMRI 22701
            |.|:     .|::...:...|:.:.|                 ...:....|.|..     ||.|
Mouse   411 ASNL-----AGQRRQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLI 470

  Fly 22702 ITNEGEEINSAEIGDNLKLQVD-VEPATIYGGFARSCIAKTMEDNVQNEYLVTDENGCATDTSIF 22765
                 .|.:..|:..|..|::: ||   :|.|....|::.|...:::.:..|          .:.
Mouse   471 -----SEDSRFEVSKNGTLRINSVE---VYDGTLYRCVSSTPAGSIEAQARV----------QVL 517

  Fly 22766 GNWEYNPDTNSLLASFNAFKFPSSDNIRFQCNIRVCFGRCQPVNCGGYNAFGRRRRSI----ADN 22826
            ...::.|              |....   ||   :.|.:...|.|   :|.||.:.::    ||.
Mouse   518 EKLKFTP--------------PPQPQ---QC---MEFDKEATVPC---SATGREKPTVKWVRADG 559

  Fly 22827 ST--------------------DA---TAIATNSGVEGQLREEITISSNAILTFE 22858
            |:                    ||   |.||:|. .:||:|..:.::....:||:
Mouse   560 SSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNE-PQGQIRAHVQLTVAVFITFK 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	48/279 (17%)
		Zona_pellucida	<22714..22810	CDD:278526	15/96 (16%)
Ptk7	XP_006524986.1	IGc2	63..125	CDD:197706
		Ig2_PTK7	164..240	CDD:143237	14/75 (19%)
		Ig_3	245..320	CDD:372822	13/74 (18%)
		IGc2	354..416	CDD:197706	17/78 (22%)
		Ig	430..516	CDD:386229	17/103 (17%)
		Ig	521..606	CDD:386229	22/108 (20%)
		Ig	627..687	CDD:319273
		PTK_CCK4	808..1081	CDD:133178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900