DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and Fbn2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_114014.2 Gene:Fbn2 / 689008 RGDID:620910 Length:2907 Species:Rattus norvegicus


Alignment Length:3223 Identity:794/3223 - (24%)
Similarity:1083/3223 - (33%) Gaps:1146/3223 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 QPQPFKTNLRANSRFRGEVFYLNLENGYFGCQ-VNESTEYLQLFNLSKLCDGTQ----------D 79
            ||||.:         ||  |..|:..|  .|| |:|...      :..||.|..          .
  Rat   257 QPQPCR---------RG--FIPNIRTG--ACQDVDECQA------IPGLCQGGNCINTVGSFECR 302

  Fly    80 CFLGADELSKELKC--TNDCDKDGTKCTHGACLNGV----CHCNDGY----GGCNCVDKDENECK 134
            |..|..:.....||  .::|......|..|.|.|.|    |.|..|:    .|..|:|:....| 
  Rat   303 CPAGHKQSETTQKCEDIDECSVVPGICETGDCSNTVGSYFCLCPRGFVTSTDGSRCIDQRTGTC- 366

  Fly   135 QRPCDVFAHCTN---------TLGSFTCTCFPG-------------------YR----------- 160
                  |:...|         .:....|.|.||                   ||           
  Rat   367 ------FSGLVNGRCAQELPGRMAKAQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCLDGLPMGG 425

  Fly   161 -------------------------------GNGFH-----------------------CEDIDE 171
                                           ||||.                       .:.||.
  Rat   426 IPGSSVSRPGGSGGNSNGYGPGGTGFLPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDI 490

  Fly   172 CQDPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDEC-RNPENCGPNALCTNTPGNY 235
            |:..  |..|: |..|....:.:.|:|..||:.|....|.||||| .||.:.|.   |.||||:|
  Rat   491 CKHH--ANLCL-NGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCSHGD---CVNTPGSY 549

  Fly   236 TCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNLEGSYRCDCPPGYD--GDGRSESGCVD 298
            .|.|..|: ...|.::.|.|:|||....|......|.|.:|.::|.|..|::  .||.:   |||
  Rat   550 YCKCHAGF-QRTPTKQACIDIDECIQNGVLCKNGRCVNTDGRFQCICNAGFELTTDGEN---CVD 610

  Fly   299 QDECARTPCGRNADCLNTDGSFRCLCPDGYSGDPMNG--CEDVDECATNNPCGLGAECVNLGGSF 361
            .|||..|....|..|:|.||||:|:|..|:...| ||  |.|||||.|...| :...|:|..|||
  Rat   611 HDECTTTNMCLNGMCINEDGSFKCVCKPGFVLAP-NGRYCTDVDECQTPGIC-MNGHCINNEGSF 673

  Fly   362 QCRCPSGFVLEHDPHADQLPQPLNTQQLGYG-----------PGATDIA-------------PYQ 402
            :|.||.|..:..|   .::....:.:...||           |||...:             |.|
  Rat   674 RCDCPPGLAVGVD---GRVCVDTHMRSTCYGEIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQ 735

  Fly   403 R-------------TSGAGLAC--LDIDECN-QPDGVAKCGTNAKCINFPGSYRCLCPSGFQ--- 448
            .             :.|.|:..  .||:||. .||..|    |..|.|..|||||.|.||::   
  Rat   736 PCPAKNSAEFHGLCSGGVGITVDGRDINECALDPDICA----NGICENLRGSYRCNCNSGYEPDA 796

  Fly   449 -GQGYLHCENINECQDNP--CGENAICTDTVGSFVCTCKPDYTGDPFR----GCVDIDECTALDK 506
             |:   :|.:|:||..|.  | :|.:|.:|.||:.|||.|.|.   ||    .|.|::||.:  .
  Rat   797 SGR---NCIDIDECLVNRLLC-DNGLCRNTPGSYSCTCPPGYV---FRTETETCEDVNECES--N 852

  Fly   507 PCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVD----VNI---LCSSNFD-CTNNAEC--- 560
            || .:..|.|.:..::|:|..|........:..:.:.    :||   .|..|.: .|..:||   
  Rat   853 PC-VNGACRNNLGSFHCECSPGSKLSSTGLICIDSLKGTCWLNIQDNRCEVNINGATLKSECCAT 916

  Fly   561 -----------IENQCFCLDGFEPI-GSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYV 613
                       .|....|..||..| |.:|.|::||.....|| |:.:|:|..||:.|||..|..
  Rat   917 LGTAWGSPCERCELDAACPRGFARIKGVTCEDVNECEVFPGVC-PNGRCVNNKGSFHCECPEGLT 980

  Fly   614 --GSPPRMACKQPCEDVRCGAHAYCKPDQNEAY-----------CVCEDGWTY------------ 653
              |:      .:.|.|||. .|.:.|.|::|..           |.|..|..:            
  Rat   981 LDGT------GRVCLDVRM-EHCFLKWDEDECVHPVPGKFRMDACCCAVGAAWGTECEECPKPGT 1038

  Fly   654 --------------NPSDVAAG---CVDIDECDVMHG--PFGSCGQNATCTNSAGGFTCACPPGF 699
                          |..|:..|   ..||:||....|  .:|.      |.|:.|.|.|.|..||
  Rat  1039 KEYETLCPRGPGFANRGDILTGRPFYKDINECKAFPGMCTYGK------CRNTIGSFKCRCNSGF 1097

  Fly   700 SGDPHSK-CVDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANED 763
            :.|...: |.|:||||.....||:|. |||.|                                 
  Rat  1098 ALDMEERNCTDIDECRISPDLCGSGI-CVNTP--------------------------------- 1128

  Fly   764 CPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGCN 828
                                                       |...|.|..||.....:...|.
  Rat  1129 -------------------------------------------GSFDCECFEGYESGFMMMKNCM 1150

  Fly   829 DIDECRANP-CAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQDS 892
            |||||..|| ......|.||.|.:.|.||.|....|.||.||.......|| |.|..|: ||  :
  Rat  1151 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCIDINECSLSD-NLCRNGK-CV--N 1211

  Fly   893 YTGNSVCICRQGYERNSENGQCQDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIM 957
            ..|...|.|..||:...:...|.|:|||.:..|    |.:..|.|..|||||.|.:|        
  Rat  1212 MIGTYQCSCNPGYQATPDRQGCSDIDECMIMNG----GCDTQCTNSEGSYECSCSEG-------- 1264

  Fly   958 CEICNTPECQCQSPYKLV--GNSCV-LSGCSSGQACPSGAECISIAGGVSY-CACPKGYQTQPD- 1017
                          |.|:  |.||. :..|.:......|.:|.:|.|  .| |.|..|:....| 
  Rat  1265 --------------YALMPDGRSCADIDECENNPDICDGGQCTNIPG--EYRCLCYDGFMASMDM 1313

  Fly  1018 GSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRKCAADRECAANEK 1082
            .:|:||:|| :....:|.|| :|.|..||:.|||..||.                          
  Rat  1314 RTCIDVNEC-DLNPNICMFG-ECENTKGSFICHCQLGYS-------------------------- 1350

  Fly  1083 CIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPSDPP---QCMCEAGFKGDPLLGCTD 1144
             ::.|...|        .|.::|:.....  |.::|.|.  :.|   :|.|..|:.|:. :.|.|
  Rat  1351 -VKKGATGC--------TDVDECEIGAHN--CDMHASCL--NVPGSFKCSCREGWVGNG-IKCID 1401

  Fly  1145 EDECSH--LPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDCASNL-AC 1206
            .||||:  ..|:..|.|||..|.|:|.|.:.:|||.:             .|...|:||.|: .|
  Rat  1402 LDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGF-------------TCSDVDECAENINLC 1453

  Fly  1207 LEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQDV-ICGDGALCI--PTS 1268
            ..|.|::.       ..||        .|.|.:|:....|.   ..|||: .|....:|:  ..:
  Rat  1454 ENGQCLNV-------PGAY--------RCECEMGFTPASDS---RSCQDIDECSFQNICVFGTCN 1500

  Fly  1269 EGP---TCKCPQG-QLGNPFPGGSCS-TDQCSAARPCGERQICINGRCKERCEGVVCGIGATCDR 1328
            ..|   .|.|..| :|..  .||:|: .|:|  |.|..    |:||.|..           |..|
  Rat  1501 NLPGMFHCICDDGYELDR--TGGNCTDIDEC--ADPIN----CVNGLCVN-----------TPGR 1546

  Fly  1329 NNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGEN--AHC----------------EYGLGQSR- 1374
            .  :|.|.|:|..||..:            ||.:|  .:|                |.|:|.|| 
  Rat  1547 Y--ECNCPPDFQLNPTGV------------GCVDNRVGNCYLKFGPRGDGSLSCNTEVGVGVSRS 1597

  Fly  1375 -CACNPG-TFGNPYEGCGAQSKNVCQP-NSCGPNAECRAVGNHISCLCP--QGFSGNPY-IGCQD 1433
             |.|:.| .:|||.|        .|.| ||           .....|||  :||..||. |..:|
  Rat  1598 SCCCSLGKAWGNPCE--------TCPPVNS-----------TEYYTLCPGGEGFRPNPITIILED 1643

  Fly  1434 VDECANKPCGL--NAACLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECPEG 1496
            :|||...| ||  ...|:|..|.|:|.|..|:    |.|   .|::.|:|.::|..:..|     
  Rat  1644 IDECQELP-GLCQGGNCINTFGSFQCECPQGY----YLS---EETRICEDIDECFAHPGV----- 1695

  Fly  1497 YSCQKGQCKNLCSQASCGPRAICDAGN--CICPMGYIGDPHDQV---HGC-----SIRGQCGNDA 1551
              |..|.|.|             ..||  ||||..|:     ||   |.|     |...:..|..
  Rat  1696 --CGPGTCYN-------------TLGNYTCICPPEYM-----QVNGGHNCMDMRKSFCYRSYNGT 1740

  Fly  1552 DCLHSEICFQLGKGLRKCVDACSKI---QCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPE 1613
            .| .:|:.|.:.|.:..|.....|.   .|.|.....:.|.::.|       ||...........
  Rat  1741 TC-ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC-------GNIPGFTFDIHTG 1797

  Fly  1614 RTVPEEEDKCKSDQDCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHAICNCAESYVW 1678
            :.|  :.|:|                   ||...:|:|.||       ||..|...|.|...:.:
  Rat  1798 KAV--DIDEC-------------------KEIPGICANGVC-------INQIGSFRCECPTGFSY 1834

  Fly  1679 NPVVSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRCDCLN 1743
            |.::..||  .:.:|::..|                        .|..|:.|:......||:|..
  Rat  1835 NDLLLVCE--DIDECSNGDN------------------------LCQRNADCINSPGSYRCECAA 1873

  Fly  1744 GFVGNPN----DRNGCQPAQKHHCRNHAEC---QESEACI-----KDESTQTLGCRPA--CDTVK 1794
            ||..:||    |||.|  .:..:..:|..|   |.|..||     |....||: |...  |:...
  Rat  1874 GFKLSPNGACVDRNEC--LEIPNVCSHGLCVDLQGSYQCICNNGFKASQDQTM-CMDVDECERHP 1935

  Fly  1795 CGPRAVCVTNNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNHDCPPSQMCNRMTHTCFDVCDEE 1859
            || ...|........|.|.||               ....:|:||.....|:....   .||   
  Rat  1936 CG-NGTCKNTVGSYNCLCYPG---------------FELTHNNDCLDIDECSSFFG---QVC--- 1978

  Fly  1860 SCGDNAICLAEDHRAVCQCPPGFKGDP-------------LPEVACTKQGGCAAGTCHPSAICEV 1911
               .|..|..|.....|.|..|::..|             ||       |.|:.|||.       
  Rat  1979 ---RNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALP-------GSCSPGTCQ------- 2026

  Fly  1912 TPEGPV-CKCPPLFVGDAKSGGCRPDGQC---PNGDADCPANTICAGGVCQNPCDNACGSNAECK 1972
            ..||.. |.|||.:  :.||..|....:|   ||         ||..|.|.|             
  Rat  2027 NLEGSFRCICPPGY--EVKSENCIDINECDEDPN---------ICLFGSCTN------------- 2067

  Fly  1973 VINRKP---VCSCPLRFQPISDTAKDGCARTISKCLTDVDCGGALCYNGQCRI-----------A 2023
                .|   .|.||..| .:||..:.......|.|.|:.:       ||:|.:           .
  Rat  2068 ----TPGGFQCICPPGF-VLSDNGRRCFDTRQSFCFTNFE-------NGKCSVPKAFNTTKAKCC 2120

  Fly  2024 CRNSQDCSDGESCLKNVCVVACLDHSQCASGLACVEGHCTIGCRSNKECKQDQSCIENKCLNPCQ 2088
            |........|:.|      ..|....:.|....|..||.|:  .|..:.::|    .|:||   :
  Rat  2121 CSKMPGEGWGDPC------ELCPKDDEVAFQDLCPYGHGTV--PSLHDTRED----VNECL---E 2170

  Fly  2089 SANSCGPNALCSIDQHHSQCSCPEGFEGNPTPEQGCVRVPAPCLASNQCPSGHMCIGNQCNLPCT 2153
            |...|. |..|.......:|.||.|:                    |...||         :.|.
  Rat  2171 SPGICS-NGQCINTDGSFRCECPMGY--------------------NLDYSG---------VRCV 2205

  Fly  2154 KTASCAVGERCYQQVCRKVCYTSNNCLAGEICNSDRTCQPG----CDSDADCPPTEL-----CL- 2208
            .|..|::|..|....|.       |.:....||.:...:||    |:...:|....|     |: 
  Rat  2206 DTDECSIGNPCGNGTCA-------NVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMN 2263

  Fly  2209 ---TGKCKCATGFI--GTPFGCSDIDECTE--QPCHA-SARCENLPGTYRCVCPEGTV--GDGYS 2263
               :.:|.|..|:.  .....|.|:|||.|  ..|.: ...|:||.||:.|:||.|..  .||  
  Rat  2264 TFGSYECTCPVGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDG-- 2326

  Fly  2264 QPGCSQPRQCH-KPDDCANNLACIH---------------------------GKCTDPCLHTVCG 2300
             .||....:|. ||..|.|. .|::                           |.|....|.|:|.
  Rat  2327 -EGCVDENECRTKPGICENG-RCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTMCQ 2389

  Fly  2301 I-----NANCQSE---------GHEA-LCSCPAGFLGDPNDTGVGCFKVECIDHVDCAGDRACDA 2350
            :     |...:||         ||:. ||..|          |...:|..|......|.|     
  Rat  2390 MASSSRNLVTKSECCCDGGRGWGHQCELCPLP----------GTAQYKKICPHGPGYATD----- 2439

  Fly  2351 ETNRCIKPCDL--TSCGKGNCQVRDHKATCACYEGY--QLVNDVCEDINECLSQPCHSTAFCNNL 2411
              .|.|..|.:  :.|..|.|........|.|..||  .:....|.|::||...|......|.|.
  Rat  2440 --GRDIDECKVMPSLCTNGQCVNTMGSFRCFCKVGYTTDISGTACVDLDECSQSPKPCNFICKNT 2502

  Fly  2412 PGSYSCQCPEGLIGDPLQAGCRDPNECLSDADCPASASCQNSRCRSPCERQNACGLNANCQAQAH 2476
            .|||.|.||.|.:.......|:|.:||.:                    :|:.|           
  Rat  2503 EGSYQCSCPRGYVLQEDGKTCKDLDECQT--------------------KQHNC----------- 2536

  Fly  2477 QAICTCPLNSRGDPTIECV------HIECADNDDCSGEKACLDSKCIDPCSLPNACGALARCSVQ 2535
            |.:|   :|:.|..|.:|.      |..|.||::|.              |.|:.|||...|  |
  Rat  2537 QFLC---VNTLGGFTCKCPPGFTQHHTACIDNNECG--------------SQPSLCGAKGIC--Q 2582

  Fly  2536 NHIG--VCSCEAGSTGDAK-LGCVQLQYCQQDGQCAQGSICSHGICSPLCSTNRDCISEQLCLQG 2597
            |..|  .|.|:.|.:.||. |.|..:..|..:.:|..|  |.:.:....|.          |.||
  Rat  2583 NTPGSFSCECQRGFSLDASGLNCEDVDECDGNHRCQHG--CQNILGGYRCG----------CPQG 2635

  Fly  2598 VCQGTCKSNSSCPQFQFCSNNICTKELECRSDSECGEDETCLSDAYGRAKCESVCLGRAACGRNA 2662
            ..|          .:|:   |.|..|.||.:...||                           :|
  Rat  2636 YVQ----------HYQW---NQCVDENECSNPGACG---------------------------SA 2660

  Fly  2663 ECVARSHAPDCLCKEGF-FGDAKSGCRKIECTSDDDCSNDKSCDNHMCKIACLIGQPCGENALCT 2726
            .|.....:..|.|..|| |....|.|..:     ::||:.|:                       
  Rat  2661 SCYNTLGSYKCACPSGFSFDQFSSACHDV-----NECSSSKN----------------------- 2697

  Fly  2727 TEHHQQVCHCQPGFSGDPRVRCDVIDFCRDAPCGPGARCRNARGSYKCTCPPG---------LVG 2782
                                           ||..|  |.|..|.|.|.||||         :.|
  Rat  2698 -------------------------------PCSYG--CSNTEGGYLCGCPPGYFRVGQGHCVSG 2729

  Fly  2783 DPYNEGCRSSVECETNED---CPPHAA--CTKTNGVAK 2815
            ..:|:|...||:.|..:|   ..|.|.  | |.||.||
  Rat  2730 MGFNKGQYLSVDSEAEDDENALSPEACYEC-KINGYAK 2766

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 12/121 (10%)
EGF_CA 212..247 CDD:238011 17/35 (49%)
EGF_CA 255..>286 CDD:214542 10/30 (33%)
EGF_CA 298..331 CDD:238011 15/32 (47%)
EGF_CA 338..373 CDD:238011 16/34 (47%)
EGF_CA 413..456 CDD:238011 19/47 (40%)
EGF_CA 457..490 CDD:238011 15/34 (44%)
EGF_CA 497..>529 CDD:214542 9/31 (29%)
EGF_CA 580..>612 CDD:214542 13/31 (42%)
EGF_3 676..702 CDD:289699 9/25 (36%)
EGF_CA 1022..1056 CDD:214542 15/33 (45%)
EGF_CA 2227..2260 CDD:238011 15/37 (41%)
EGF_CA 2393..>2422 CDD:214542 12/28 (43%)
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Fbn2NP_114014.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I10950
eggNOG 1 0.900 - - E33208_3BA2W
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45515
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

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