DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Hmcn2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_006498564.1	Gene:	Hmcn2 / 665700	MGIID:	2677838	Length:	5092	Species:	Mus musculus

Alignment Length:	487	Identity:	145/487 - (29%)
Similarity:	198/487 - (40%)	Gaps:	104/487 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LNGVCHCNDGYGGCNCVDKDENECKQRPCDVFAHCTNTL------GSFTCTCFPGY-RGNGFHCE 167
            :||:...:...|.....|..|:..:..|..:||..|...      .|..|.....| ...|...:
Mouse  4543 INGMIPESLADGDLRVQDFQEHYVQTGPGQLFAGSTQRFLHDSLPASLRCNHSIQYDETRGLQPQ 4607

  Fly   168 DIDECQDPAIAARCVENAECCNLPAHFLCK-------CKDGYEGDGE-VLCTDVDECR-NPENCG 223
            .:...:..:|::.....||..|.......:       |.:|:|.|.: ..|.|.|||. .|..|
Mouse  4608 LVQHLRASSISSAFDPEAEALNFQLTTALQTEENEVGCPEGFEPDVQGAFCVDKDECSGGPSPC- 4671

  Fly   224 PNALCTNTPGNYTCSCPDGYVGNNPYREGCQDVDECS-YPNVCGPGAICTNLEGSYRC--DCPPG 285
             :..|.|.||:::||||.|:.....:| .|:|||||: ..::|.....|.||.|||.|  .|.||
Mouse  4672 -SHTCRNAPGHFSCSCPTGFSLAWDHR-NCRDVDECAGNTHLCQEEQRCVNLLGSYNCLASCRPG 4734

  Fly   286 Y--DGDGRSESGCVDQDECAR--TPCGRNADCLNTDGSFRCLCPDGY--SGDPMNGCEDVDEC-A 343
            :  ..||   |.|.|.|||..  ..|..|..|.||.|...|.||.||  .|..: .|.|::|| .
Mouse  4735 FRVTADG---SNCEDVDECLEQLDECHYNQLCENTPGGHHCGCPRGYRQQGHSL-PCLDINECLQ 4795

  Fly   344 TNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQL-------GYGPGATDIAPY 401
            ...||..  :|.||.||::|.||.|..|..|... .:|...|.|.:       .:||......|.
Mouse  4796 LPTPCVY--QCQNLQGSYRCLCPPGQTLLRDGRT-CIPLERNRQNITIVSHRSPFGPWLRSRVPR 4857

  Fly   402 QRTS---------GAGL------------------ACLDIDECNQPDGVAKCGTNAKCINFPGSY 439
            ..:|         |:|.                  .|.|:|||.    |.....:| |.|..|||
Mouse  4858 PSSSYHTWVSLRPGSGALNSVGRAWCPPGFIRQDGVCADLDECR----VRSLCQHA-CQNTEGSY 4917

  Fly   440 RCLCPSGFQ----GQGYLHCENINECQDN--PCGENAICTDTVGSFVCT---CKPDY-----TGD 490
            .||||||::    |:   :|::||||:::  .||...:|.:|.|||.|.   |...|     .|.
Mouse  4918 YCLCPSGYRLLPSGK---NCQDINECEEDGIECGPGQMCFNTRGSFQCVDTPCPTTYRQGSSPGT 4979

  Fly   491 PFRGCVDIDECTA----------LDKPCGQHA 512
            .||.|  ..:|:|          |..|.|..|
Mouse  4980 CFRRC--SQDCSASGPSTLQYRLLPLPLGVRA 5009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	8/35 (23%)
		EGF_CA	212..247	CDD:238011	15/35 (43%)
		EGF_CA	255..>286	CDD:214542	15/33 (45%)
		EGF_CA	298..331	CDD:238011	15/36 (42%)
		EGF_CA	338..373	CDD:238011	15/35 (43%)
		EGF_CA	413..456	CDD:238011	18/46 (39%)
		EGF_CA	457..490	CDD:238011	14/42 (33%)
		EGF_CA	497..>529	CDD:214542	6/26 (23%)
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Hmcn2	XP_006498564.1	vWFA	38..196	CDD:238119
		Ig	445..511	CDD:319273
		IG	525..605	CDD:214652
		I-set	609..693	CDD:369462
		IG	707..783	CDD:214652
		IG_like	793..876	CDD:214653
		I-set	889..969	CDD:369462
		Ig	992..1058	CDD:386229
		IG	1076..1157	CDD:214652
		Ig	1161..1242	CDD:386229
		Ig	1262..1336	CDD:386229
		I-set	1345..1429	CDD:369462
		I-set	1449..1523	CDD:369462
		IG	1553..1633	CDD:214652
		IGc2	1654..1716	CDD:197706
		Ig	1741..1819	CDD:386229
		Ig	1839..1903	CDD:386229
		I-set	1907..1986	CDD:369462
		Ig_3	1998..2073	CDD:372822
		Ig	2092..2179	CDD:386229
		Ig	2183..2273	CDD:386229
		Ig	2291..2367	CDD:386229
		IGc2	2389..2451	CDD:197706
		I-set	2476..2554	CDD:369462
		I-set	2558..2650	CDD:369462
		I-set	2668..2740	CDD:369462
		Ig	2782..2859	CDD:386229
		I-set	2876..2954	CDD:369462
		I-set	2966..3046	CDD:369462
		I-set	3050..3141	CDD:369462
		Ig	3145..3233	CDD:386229
		Ig	3256..3320	CDD:319273
		Ig	3347..3422	CDD:386229
		IG_like	3436..3511	CDD:214653
		IGc2	3530..3592	CDD:197706
		Ig	3614..3695	CDD:386229
		I-set	3699..3786	CDD:369462
		Ig	3789..3874	CDD:386229
		Ig	3900..3967	CDD:319273
		I-set	3974..4060	CDD:369462
		Ig	4064..4151	CDD:386229
		I-set	4155..4240	CDD:369462
		IGc2	4259..4321	CDD:197706
		I-set	4335..4421	CDD:369462
		G2F	4423..4605	CDD:369383	13/61 (21%)
		FXa_inhibition	4664..4699	CDD:373209	13/37 (35%)
		EGF_CA	4701..4744	CDD:311536	19/45 (42%)
		EGF_CA	4746..4783	CDD:214542	15/36 (42%)
		EGF_CA	4789..4829	CDD:214542	16/42 (38%)
		EGF_CA	4896..4935	CDD:214542	18/46 (39%)
		EGF_CA	4936..4974	CDD:214542	14/37 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900