DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and SIGLEC1

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_075556.1 Gene:SIGLEC1 / 6614 HGNCID:11127 Length:1709 Species:Homo sapiens


Alignment Length:1790 Identity:343/1790 - (19%)
Similarity:527/1790 - (29%) Gaps:530/1790 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  4186 FEASTPSPASLETTVPSVTLETTTNDPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRT 4250
            |...|....:.|..|.::.|:....:..||...:......:..|:|:.|:              .
Human    83 FRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL--------------V 133

  Fly  4251 TPSESPETPT-TLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSSASLETT---------VPSV 4305
            |.:|.|..|| ..|.:.:.....|              |..|||.....|..         ..||
Human   134 TVTEEPRVPTIASPVELLEGTEVD--------------FNCSTPYVCLQEQVRLQWQGQDPARSV 184

  Fly  4306 TLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSE-------------- 4356
            |..:....|.| .|...|.....|..:....:|.:.|.     |:....||              
Human   185 TFNSQKFEPTG-VGHLETLHMAMSWQDHGRILRCQLSV-----ANHRAQSEIHLQVKYAPKGVKI 243

  Fly  4357 --SPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNV---- 4415
              ||.....||.:..|               .|....:|.|:.:|::.....|.|:|.|.|    
Human   244 LLSPSGRNILPGELVT---------------LTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLP 293

  Fly  4416 -PIGSTGGQVT-------GQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDF-- 4470
             ...|..|..|       |...|.|..:...:...:.:......:..|.:....||...|||.  
Human   294 QAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRY 358

  Fly  4471 ----------ITRPHSEKTTESTR--------DVPTTRPFEASTPSSASLE----TTVPSVTLET 4513
                      ....|:.:...:||        :|......|.|.|.|..:.    |.|.:..|||
Human   359 SWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLET 423

  Fly  4514 TTNV-----------PIG----STGGQVTEQT------------TSSPSEVRTTIRVEESTLPSR 4551
            ...:           |:.    |.||.:...|            ||.|:.:|..||..|.|    
Human   424 QAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEET---- 484

  Fly  4552 SADRTTLSESPETPTTLPSDFTIRPHSEQTTESTRDVPTTRPFEASTP----SPASLETTVPSVT 4612
                    :|.|             :....|.|..:..:|..|.|:..    |||:         
Human   485 --------DSGE-------------YKCSATNSLGNATSTLDFHANAARLLISPAA--------- 519

  Fly  4613 SETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPS-------------ESP 4664
                         ..|.||..               ||..||....||.             |.|
Human   520 -------------EVVEGQAV---------------TLSCRSGLSPTPDARFSWYLNGALLHEGP 556

  Fly  4665 ETPTILPSDSTTRTYSDQTTESTRDVPTTRPFEASTP-SPASLETTVPSVTLETTTNVPIGSTG- 4727
            .:..:||:.|:|...|...  ..||     ...||.| |||.|....|......||.:.:.:.| 
Human   557 GSSLLLPAASSTDAGSYHC--RARD-----GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614

  Fly  4728 -----GQVTEQTTSSPS---EVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDF----ITRP 4780
                 |.:..:..|.|.   ::....||..::|||.....|....||....|...:.    |..|
Human   615 GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNP 679

  Fly  4781 HSE-------KTTESTRDVPTTRPFE------ASTPSSASLETTVPSVT---------------- 4816
            ..|       :.:.:..:..|:..|.      |..||....|.|..::|                
Human   680 LLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW 744

  Fly  4817 -----------LETTTNVPIGSTGGQV--TEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESP 4868
                       |||.|.:|:..|...:  ....|.:.:::.|.:.:  |.|        .|.:.|
Human   745 FRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLL--SVL--------YPPDRP 799

  Fly  4869 ETPTTLPSD------FI----TRP-------HSEK--TTESTRDVPTTRPFEASTPSSASLETTV 4914
            :....|...      ||    :||       |.|.  .|.....||:...|:|...::       
Human   800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN------- 857

  Fly  4915 PSVTLETTTNVPIGSTGGQVTEQTT---SSPSEVRTTIR---VEESTLPSRSTDRTTPSESPETP 4973
             |:.|| ...:.:|.:|....|.|.   ||.:.:...:|   |:.|..|.....:.... |.:..
Human   858 -SLKLE-VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVL-SCQVH 919

  Fly  4974 TTLPSDFTTR------PHSEQTTESTRDVPTTRP------FEASTPSPASLETTVP--------- 5017
            |.:|...:.|      |..|.|:.:.|....|..      .:|..|..|:.....|         
Human   920 TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984

  Fly  5018 -SVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTT--IRVEESTL-----PSRSADRTTPSESPET 5074
             .|||.|..:...|..|..:....:..|:::|..  .|:..|||     |..|:.|...:.:|.|
Human   985 RHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNT 1049

  Fly  5075 ------PTTLPSDFITRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPI-- 5131
                  ...|..:.:   |..:.:.:......:..|:|.                  ..||.:  
Human  1050 LRLEIHGAMLEDEGV---YICEASNTLGQASASADFDAQ------------------AVNVQVWP 1093

  Fly  5132 GST--GGQVTGQT----TAPPSEFRTT------IRVEESTLPSRST---DRTT-------PSESP 5174
            |:|  .||:...|    |..|::...|      .|::..::|..:.   |.|:       |..:|
Human  1094 GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAP 1158

  Fly  5175 ETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQ 5239
            .         .:||.:.....:.|::..|...|:.....|.:..||.|   .....:.:...|..
Human  1159 R---------LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDS---RPPAQLALSHAGRL 1211

  Fly  5240 VTEQTTSSPSEVRTTIRVE-ESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPA 5303
            :...|.:|   |..|:|:| ....|......:..:.||......|       .|...|..|.:.|
Human  1212 LASSTAAS---VPNTLRLELRGPQPRDEGFYSCSARSPLGQANTS-------LELRLEGVRVILA 1266

  Fly  5304 TRPFEASTPSPASLETTVPSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRST 5368
            .   ||:.|..|.:..|.....:.|.|.......|..:.|...:|.|.:..| |........::.
Human  1267 P---EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT-RAHAGAYSCQAQ 1327

  Fly  5369 DRTSPSESPETPTTLPSDFTTRPHSDQTTECTRDVPTTRPFEASTPSSASLETTVPS-----VTL 5428
            |......|             ||.:.|.....:|...:...::...|.|.::.||.|     :.|
Human  1328 DAQGTRSS-------------RPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELAL 1379

  Fly  5429 ETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPH 5493
            .....|...|:|.......|......|..:|::...:|  :.|.|.                   
Human  1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVP--AGDDTY------------------- 1423

  Fly  5494 SEQTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGST--------GGQVTEQTTS 5550
                      |.|.:....|..:...|:.....|..|...:||.|:.        ||        
Human  1424 ----------VCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGG-------- 1470

  Fly  5551 SPSEFRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEAST 5615
             |..      |..||......||...:|  ..|||.  ||   |..:............|..|:.
Human  1471 -PGP------VGNSTFAWFWNDRRLHAE--PVPTLA--FT---HVARAQAGMYHCLAELPTGAAA 1521

  Fly  5616 PSPASLETTVPSVTSETTTNV-PIGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTTPSE 5679
            .:|..|....|..|......| |.|...|.:..:..:.|....|.      .|.||....:.|..
Human  1522 SAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTL------HLGSRLVASSQPQG 1580

  Fly  5680 SPETPTI--LPSDSTTRTYSDQTTESTRDVPTTRP 5712
            :|..|.|  |.|.:..|.          |:...||
Human  1581 APAEPHIHVLASPNALRV----------DIEALRP 1605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572 17/96 (18%)
DUF4696 4127..4678 CDD:292395 112/597 (19%)
DUF4758 4275..4448 CDD:292572 38/209 (18%)
DUF4758 4377..4574 CDD:292572 49/259 (19%)
DUF4758 4581..4754 CDD:292572 43/199 (22%)
DUF4758 4683..4847 CDD:292572 44/219 (20%)
DUF4758 4785..4964 CDD:292572 45/238 (19%)
DUF4696 4841..5385 CDD:292395 119/628 (19%)
DUF4758 4887..5098 CDD:292572 50/251 (20%)
DUF4758 5193..5371 CDD:292572 36/178 (20%)
DUF4758 5294..5487 CDD:292572 37/197 (19%)
DUF4758 5445..5650 CDD:292572 40/213 (19%)
DUF4758 5700..5877 CDD:292572 3/13 (23%)
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
SIGLEC1NP_075556.1 Ig 21..136 CDD:299845 11/66 (17%)
IG_like 26..135 CDD:214653 10/65 (15%)
Sialic acid binding. /evidence=ECO:0000250 122..126 0/3 (0%)
C2-set_2 142..228 CDD:285423 20/105 (19%)
Ig_2 245..323 CDD:290606 20/92 (22%)
IG_like 247..323 CDD:214653 19/90 (21%)
Ig 336..408 CDD:299845 14/71 (20%)
IG_like 338..408 CDD:214653 14/69 (20%)
Ig 430..503 CDD:143165 17/97 (18%)
IG_like 431..503 CDD:214653 17/96 (18%)
Ig_2 514..594 CDD:290606 28/123 (23%)
IG 516..594 CDD:214652 28/121 (23%)
IG_like 624..703 CDD:214653 15/78 (19%)
IG_like 715..792 CDD:214653 13/78 (17%)
ig 715..788 CDD:278476 13/72 (18%)
Ig 809..893 CDD:299845 20/92 (22%)
I-set 898..980 CDD:254352 16/82 (20%)
Ig_2 900..980 CDD:290606 15/80 (19%)
Ig 1003..1080 CDD:143165 13/79 (16%)
Ig_2 1093..1168 CDD:290606 16/83 (19%)
IG_like 1093..1168 CDD:214653 16/83 (19%)
I-set 1186..1256 CDD:254352 15/82 (18%)
Ig_2 1263..1342 CDD:290606 18/95 (19%)
IG_like 1271..1342 CDD:214653 15/84 (18%)
Ig 1363..1442 CDD:299845 18/109 (17%)
IG_like 1455..1529 CDD:214653 22/95 (23%)
Ig 1457..1518 CDD:299845 17/82 (21%)
Ig <1552..1630 CDD:299845 15/70 (21%)
IG 1552..1627 CDD:214652 15/70 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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