DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Susd1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001156760.2	Gene:	Susd1 / 634731	MGIID:	3651543	Length:	752	Species:	Mus musculus

Alignment Length:	427	Identity:	106/427 - (24%)
Similarity:	151/427 - (35%)	Gaps:	140/427 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 GCQDVDECSYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDEC---ARTPCGRNADC 313
            |.:|||.|:   .|...|.|...||...|.|..|:.|:||:.  |||:|||   |...||.:..|
Mouse    37 GTEDVDVCA---TCHEHATCQQKEGKRICICNYGFWGNGRTR--CVDKDECQFGATVICGNHTSC 96

  Fly   314 LNTDGSFRCLCPDGYSGD-------PMNG--CEDVDECATNNPCGLGAECVNLGGSFQCRCPSGF 369
            .||.|.|.|:|.:||...       |.:|  |.|:|||..:..|..|..|||..|||.|.|..|:
Mouse    97 HNTPGGFYCICHEGYRATNNNETFIPNDGTFCADIDECEDSGLCRHGGRCVNTPGSFACYCMEGY 161

  Fly   370 VLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAK---CGTNAK 431
            |.::.      |:|.:.:        ||          ..:|.:|| |..|..|.:   .|:.:.
Mouse   162 VAKNG------PEPFHPR--------TD----------ATSCTEID-CGIPPEVPEGYVVGSYSS 201

  Fly   432 CINFPGSYRCLCPSGF---QGQGYLHCENIN-------ECQDNPCG-----ENAICTDTVGSFVC 481
            .:.....|.  |..||   .|.....|..:.       .||:..||     :|||..
Mouse   202 TLGGQAHYS--CKEGFLSVSGDRISRCTALGVWEPPKLHCQEISCGSPPEIQNAILV-------- 256

  Fly   482 TCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKV--------- 537
                                       |.|:..:.:|..|:|:  :|:: .|..|:
Mouse   257 ---------------------------GNHSSRQGSVAHYDCQ--EGFE-SPGGKITSVCTEKGA 291

  Fly   538 ------ACEQVDVNI--LCSSNFDCTN--------NAEC-----IENQCFCLDGFEPIGSSCVDI 581
                  ||.::.:.|  :...|..|..        ||..     :|.|  ..|..|.:....|::
Mouse   292 WSEITYACTEIMIEIHDVLVFNDTCVRWQISPERVNARIVYLIRVERQ--QPDAAESVYEETVNV 354

  Fly   582 DECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPR 618
            .......||| .|.|       .|.........:|||
Mouse   355 TTDSRTPEVC-LHLQ-------QGTNYTISISAAPPR 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542	11/30 (37%)
		EGF_CA	298..331	CDD:238011	16/35 (46%)
		EGF_CA	338..373	CDD:238011	16/34 (47%)
		EGF_CA	413..456	CDD:238011	11/48 (23%)
		EGF_CA	457..490	CDD:238011	7/44 (16%)
		EGF_CA	497..>529	CDD:214542	5/31 (16%)
		EGF_CA	580..>612	CDD:214542	6/31 (19%)
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Susd1	NP_001156760.2	EGF_3	47..74	CDD:289699	10/26 (38%)
		EGF_CA	78..116	CDD:214542	16/37 (43%)
		EGF_CA	130..>161	CDD:214542	14/30 (47%)
		CCP	184..240	CDD:153056	10/57 (18%)
		CCP	244..299	CDD:153056	13/92 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000