DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Ltbp1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_067598.2	Gene:	Ltbp1 / 59107	RGDID:	68379	Length:	1712	Species:	Rattus norvegicus

Alignment Length:	1330	Identity:	342/1330 - (25%)
Similarity:	468/1330 - (35%)	Gaps:	455/1330 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSAVHSQYSQQ-------PQPFKTNLRANSRFRGEVFYLNLENGYFGCQVNESTEYLQLFNLSKL 73
            :..|||.||.|       |...||.|       |..|...:     |.|..::     |..|||.
  Rat   523 TQTVHSTYSHQQVIPHVYPVAAKTQL-------GRCFQETI-----GSQCGKA-----LPGLSKQ 570

  Fly    74 --CDGTQDCFLGADELSKELKCTNDCDKDGTKCTHG-----ACLNGVCHCNDGYGGCNCVDKDEN 131
              |.||.....|.::..|       |.|  .:..||     .||.|....|:.:    |  :|.|
  Rat   571 EDCCGTVGTSWGFNKCQK-------CPK--KQSYHGYTQMMECLQGYKRVNNTF----C--QDIN 620

  Fly   132 ECKQRPCDVFAHCTNTLGSFTCTCFPGYRGNGFHCEDID--------------------ECQDPA 176
            ||:.:.......|.||:||:.|:|..|:..:......:.                    :|..|
  Rat   621 ECQLQGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPMISEEKGPCYRLVSPGRQCMHP- 684

  Fly   177 IAARCVENAECCN-------------LP--AHF--LCKCKDGYEGDG------------------ 206
            ::....:...||:             ||  |.|  :|....||...|
  Rat   685 LSVHLTKQICCCSVGKAWGPQCEKCPLPGTAAFKEICPGGMGYTVSGIHRRRPIHQHIGKEAVFV 749

  Fly   207 ----------------------------------------EVL---------------------- 209
                                                    ||:
  Rat   750 KPKNTQPVAKSTHPPPLPAKEEPVEALTSSREHGPGVAEPEVVTAPPEKEIPSLDQEKTRLEPGQ 814

  Fly   210 ------------------------------------------------CTDVDECR-NPENCGPN 225
                                                            .|:::||. ||:.||..
  Rat   815 PQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEGSTSSASQVIAPTQVTEINECTVNPDICGAG 879

  Fly   226 ALCTNTPGNYTCSCPDGYVGNNPYREGCQDVDECSY-PNVCGPGAICTNLEGSYRCDCPPGYDGD 289
            . |.|.|..|||.|.:||..:...|: |.|:|||:. .::|..|. |.|.|||:.|.||.|:..
  Rat   880 H-CINLPVRYTCICYEGYKFSEQQRK-CIDIDECAQAQHLCSQGR-CENTEGSFLCICPAGFMA- 940

  Fly   290 GRSESG--CVDQDECARTPCGRNADCLNTDGSFRC-LCPDGYSGDPMNGCEDVDECATNNPCGLG 351
              ||.|  |:|.|||.|....|:..|:||.|:||| .|..||.......|||:|||.|.:.|. .
  Rat   941 --SEEGSNCIDVDECLRPDVCRDGRCINTAGAFRCEYCDSGYRMSRRGHCEDIDECLTPSTCP-E 1002

  Fly   352 AECVNLGGSFQC-RCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDID 415
            .:|||..||:|| .|..||                                   .|....|||:|
  Rat  1003 EQCVNSPGSYQCVPCTEGF-----------------------------------RGWNGQCLDVD 1032

  Fly   416 ECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQ-GQGYLHCENINECQDNPCGENAICTDTVGSF 479
            ||.||    |..||..|.|..|||.|.|..|:. ...:.||::|:|||......|..|.:|.|||
  Rat  1033 ECLQP----KVCTNGSCTNLEGSYMCSCHKGYSPTPDHRHCQDIDECQQGNLCMNGQCKNTDGSF 1093

  Fly   480 VCTCKPDYTGDPFRG-CVDIDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGK--PDPKVACEQ 541
            .|||...|.....:. |.|||||.  .:....|..|.||...:.|.|.|||...  .|   .||
  Rat  1094 RCTCGQGYQLSAAKDQCEDIDECE--HRHLCSHGQCRNTEGSFQCLCNQGYRASVLGD---HCE- 1152

  Fly   542 VDVN------ILCSSNFDCTNNAECIENQCFCLDGFE-PIGSSCVDIDECRTHAEVCGPHAQCLN 599
             |:|      .:|... ||.|.|...:  |.|.||.: .....|.||:|| ....:||||.:|||
  Rat  1153 -DINECLEDSSVCQGG-DCINTAGSYD--CTCPDGLQLNDNKGCQDINEC-AQPGLCGPHGECLN 1212

  Fly   600 TPGSYGCECEAGYVGSPPRMACKQPCEDVR-------CGAHAYCKPDQNEAYCVCEDGWTYNPSD 657
            |.||:.|.||.|:..|    |..:.|||:.       |.:|.:|........|:|..|: ..|.|
  Rat  1213 TQGSFHCVCEQGFSIS----ADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGF-QAPQD 1272

  Fly   658 VAAGCVDIDECDVMHGPFGSCGQNATCTNSAGGFTCACPPGFSGDPHSKCVDV-DECRTGASKCG 721
             ..||||::||:::.   |.||: |.|.|..|.|.|.|     .|.:.:...: .:||:.|::
  Rat  1273 -GQGCVDVNECELLS---GVCGE-AFCENVEGSFLCVC-----ADENQEYSPMTGQCRSRATE-- 1325

  Fly   722 AGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANEDCPGN----SICD------ATKR- 775
                               ::..|..|.         ...::|..|    |:||      .||:
  Rat  1326 -------------------DSGVDRQPK---------EEKKECYYNLNDASLCDNVLAPNVTKQE 1362

  Fly   776 CLCPE-PNIGNDCR-HPCEALNCGAHAQCMLANGQAQCLCAPGY--TGNSAL-AGGCN--DIDEC 833
            |.|.. ...|::|. .||........::        .|....|:  .|.|:. .||.|  |.|||
  Rat  1363 CCCTSGAGWGDNCEIFPCPVQGTAEFSE--------MCPRGKGFVPAGESSYETGGENYKDADEC 1419

  Fly   834 R--ANPCAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQDSYTGN 896
            .  .....:...|.||..||.|.|..|:..||.:..|.....  |.|.|.|..|: ||...  |:
  Rat  1420 LLFGEEICKNGYCLNTQPGYECYCKEGTYYDPVKLQCFDMDE--CQDPNSCIDGQ-CVNTE--GS 1479

  Fly   897 SVCICRQGYERNSENGQC-------QDVDECSVQRGKPACGLNALC-KNLPGSY----------- 942
            ..|.|......::...:|       :.::|..|.:.        || ::|...|
  Rat  1480 YNCFCTHPMVLDASEKRCVQPTESNEQIEETDVYQD--------LCWEHLSEEYVCSRPLVGKQT 1536

  Fly   943 ---ECRCPQGHN-GNPFIMC---------EICNTPECQCQSPY---------------------- 972
               ||.|..|.. |....:|         ::||.|....:.||
  Rat  1537 TYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQ 1601

  Fly   973 --------KLVGNSC-VLSGCSSGQACPSGAECISIAGGVSYCACPKGYQ-TQPDGSCVDVDECE 1027
                    :|....| :|:||.:|:       |:.:..|.: |.|..||. .....:||||:||.
  Rat  1602 DRFLNSFEELQAEECGILNGCENGR-------CVRVQEGYT-CDCFDGYHLDMAKMTCVDVNECS 1658

  Fly  1028 E--RGAQLCAFGAQCVNKPGSYSCHCPEGY 1055
            |  ....||. .|:|:|..|||.|.|..||
  Rat  1659 ELNNRMSLCK-NAKCINTEGSYKCVCLPGY 1687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	8/28 (29%)
		EGF_CA	212..247	CDD:238011	15/35 (43%)
		EGF_CA	255..>286	CDD:214542	14/31 (45%)
		EGF_CA	298..331	CDD:238011	16/33 (48%)
		EGF_CA	338..373	CDD:238011	16/35 (46%)
		EGF_CA	413..456	CDD:238011	18/43 (42%)
		EGF_CA	457..490	CDD:238011	14/32 (44%)
		EGF_CA	497..>529	CDD:214542	12/31 (39%)
		EGF_CA	580..>612	CDD:214542	17/31 (55%)
		EGF_3	676..702	CDD:289699	10/25 (40%)
		EGF_CA	1022..1056	CDD:214542	17/36 (47%)
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Ltbp1	NP_067598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..148
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..803		2/50 (4%)
		8-Cys3 region. /evidence=ECO:0000250\|UniProtKB:Q14766	1335..1402		15/74 (20%)
		C-terminal domain. /evidence=ECO:0000250\|UniProtKB:Q14766	1498..1712		48/207 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11363
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45515
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920