DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and notch3

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_571624.2 Gene:notch3 / 58066 ZFINID:ZDB-GENE-000329-5 Length:2468 Species:Danio rerio


Alignment Length:2063 Identity:534/2063 - (25%)
Similarity:724/2063 - (35%) Gaps:694/2063 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 GCNCVDKDENECKQRPCDVFAHCTNTLGSFTCTCFPGYRGNGFHCEDIDEC-QDPAI-AARCVEN 184
            |..|||      ..|||:....|.::    .|.|.|||.|:  .|:.:|.| :.|.: ||.|  .
Zfish    21 GLLCVD------THRPCENGGMCIDS----RCLCRPGYIGS--LCQHLDPCHRSPCLNAAAC--K 71

  Fly   185 AECCNLPAHFLCKCKDGYEGDGEVLCTDVDECRNPENCGPNALCTNTPGNYTCSCPDGYVGNNPY 249
            ::..|....:.|.|:.|:.|..   |:.||.|.. ..|...|.|||...:|.||||.||.|.|  
Zfish    72 SQVANSIPQYTCVCQRGFRGQD---CSLVDACAT-SPCANGARCTNWNNHYNCSCPPGYQGKN-- 130

  Fly   250 REGCQ-DVDECSYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGC-VDQDECARTPCGRNAD 312
               |: |:|||..|..|..|.||.|..||:||:|..||.|     ..| |....||.:.|.....
Zfish   131 ---CRNDIDECRKPGKCLNGGICMNTHGSFRCECLTGYSG-----RTCEVPTQPCAPSQCLNGGT 187

  Fly   313 CLNT-DGSFRCLCPDGYSGDPMNGCED-VDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDP 375
            |..| |.::.|.|..|:.|   :.||| ||:|                                 
Zfish   188 CHQTGDHTYECACLPGFRG---HNCEDNVDDC--------------------------------- 216

  Fly   376 HADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYR 440
                             ||                             .||..|..|::...:|.
Zfish   217 -----------------PG-----------------------------HKCMNNGICVDGVNTYN 235

  Fly   441 CLCPSGFQGQGYLHC-ENINEC--QDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVD-IDEC 501
            |.||..:.||   :| |::|||  |.|.|.....|.:|:|...|.|...:|||   .|.: ||:|
Zfish   236 CQCPPEWTGQ---YCAEDVNECLMQPNACHNGGTCFNTIGGHTCVCVNGWTGD---DCSENIDDC 294

  Fly   502 -TALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQ- 564
             ||:   |...|.|.:.|..:.|:||.|..|     :.|...|.   |.|| .|...|.|..|. 
Zfish   295 ATAV---CFNGATCHDRVASFFCECPVGKTG-----LLCHLDDA---CVSN-PCNEGAVCDTNPL 347

  Fly   565 -----CFCLDGFEPIGSSC-VDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACK- 622
                 |.|..||  :|.:| .|:|||...|..|....:|:||.||:.|:|..||.|  ||  |: 
Zfish   348 NGRAICTCPAGF--VGGACNQDMDECSIGANPCEHFGKCVNTEGSFQCQCGRGYTG--PR--CEI 406

  Fly   623 --QPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDECDVMHGPFGSCGQNATCT 685
              ..|..:.|...|.|.....|..|:|..|:.....:     ||||||:     ...|..:..|.
Zfish   407 DINECLSMPCQNDATCLDRIGEFTCICMPGYQGKYCE-----VDIDECE-----SNPCVNDGICR 461

  Fly   686 NSAGGFTCACPPGFSGDPHSKC-VDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPS 749
            :...||||.|.|||:|   :.| :|:|||  .::.|..||:|::.| .||.|||.          
Zfish   462 DMVNGFTCTCQPGFTG---TMCQIDIDEC--ASTPCQNGAKCIDRP-NGYECRCA---------- 510

  Fly   750 VRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCA 814
                        |...|.         || |.||.|....||.      |..|:.......|.|.
Zfish   511 ------------EGFEGR---------LC-ESNIDNCKPDPCH------HGTCVDGIASYTCNCE 547

  Fly   815 PGYTGNSALAGGC-NDIDECRANPCAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSD 878
            |||||..     | |.::||.:|||.....|.:....|:|||..|:||        |:..:...|
Zfish   548 PGYTGYR-----CENQLNECHSNPCQNGGKCVDLVNKYICQCQHGTSG--------TNCEINFDD 599

  Fly   879 --ANPCATGETCVQDSYTGNSVCICRQGYERNSENGQCQD-VDECSVQRGKPACGLNALCKNLPG 940
              :|||..|   :.........|:|:.|:    ...||:| :|||   :..| |.....|.:...
Zfish   600 CASNPCDYG---ICKDGINRYECVCKPGF----TGPQCKDEIDEC---QSNP-CRNGGTCVDDEN 653

  Fly   941 SYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAECISIAGGVSY 1005
            .:.|:||:|.: :|:     |.:...:|.|      |.|:...|...   |:|..          
Zfish   654 GFHCQCPEGFH-DPY-----CYSQVDECAS------NPCLHGTCRDD---PNGYR---------- 693

  Fly  1006 CACPKGYQTQPDGSCVDVDE-------CEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGL 1063
            |.|..|:.    |...|:|.       |:..|.        |.::...::|.|.:|::|:    |
Zfish   694 CDCEPGWV----GKNCDLDRNDCLPSPCQNAGT--------CFDQLNGFTCKCRQGFRGN----L 742

  Fly  1064 CALAQRKCAADRECAANEKCIQPGECV---------CPPPYFLDPQDNNKCK---SPCERFPCGI 1116
            |.:...:|       |:..|:..|.||         |.|||     ....|.   :||...||..
Zfish   743 CQVNINEC-------ASSPCLNQGTCVDGVASFTCLCEPPY-----SGPTCAELLTPCSPNPCAN 795

  Fly  1117 NAKC--TPSD-PPQCMCEAGFKGDPLLGCTDEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDP 1178
            :|.|  ||.. ..||.|:.|::|.  |...|.:||:..||.....|.|..|||.|.|...|||  
Zfish   796 HASCVHTPDYLGYQCNCQPGWQGH--LCNNDINECTSNPCKNRGTCTNTLGGYVCSCRAGYTG-- 856

  Fly  1179 YKSGCIFESGTPKSKCLSN-DDCASNLACLE-GSCVSPCSSLLCG-----SNAYCETEQHAGWCR 1236
                         ..|.:: :||:.| .||. |||....:|..|.     :.|.|.||       
Zfish   857 -------------PNCETDINDCSPN-PCLNGGSCTDGVNSFRCSCLPGFTGARCATE------- 900

  Fly  1237 CRVGYVKNGDGDCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSCSTDQCSAARPCG 1301
                         :::||.|.|.:|..|.......||.|..|     |.|..|.|:    ...|.
Zfish   901 -------------LNECQSVPCKNGGTCTDYVNSYTCTCKPG-----FTGLLCETN----VPDCT 943

  Fly  1302 ERQICINGRCKERCEGVVCGIGATCDRNNG-KCICEPNFVGNPDLICMPPIEQAKCSPGCGENAH 1365
            |.. |.||             |...|..|| ||.|...|.|:                      :
Zfish   944 ESS-CFNG-------------GTCTDGINGFKCTCRTGFTGD----------------------Y 972

  Fly  1366 CEYGLGQSRCACNPGTFGNPYEGCGAQSKNVCQPNSCGPNAECRAVGNHISCLCPQGFSGNPYIG 1430
            |:|.:                        |.|....|.....|:.......|.||:|::|.   .
Zfish   973 CQYEV------------------------NECDSQPCLNGGICQDAMESYRCSCPKGYTGP---R 1010

  Fly  1431 CQ-DVDEC-ANKPCGLNAACLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVEC 1493
            || .||.| .:.||.....|..:...|.|.||.|.:|           ::|            :.
Zfish  1011 CQYPVDWCRPSNPCKNGGRCRQKDASFTCDCLGGWSG-----------RYC------------DI 1052

  Fly  1494 PEGYSC-----QKG-QCKNLCSQAS-CGPRAICDAGN---CICPMGYIGDPHDQVHGCSIRGQCG 1548
            | |.||     |:| |...||.... |     .:.||   |.||..|.|.               
Zfish  1053 P-GVSCEVAARQRGRQTDELCLHGGHC-----VNTGNTHYCKCPADYTGS--------------- 1096

  Fly  1549 NDADCLHSEICFQLGKGLRKCVDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPE 1613
                  :.|..|          |.|.:..|...|.|.|.....:|.|..|:.||      .|:  
Zfish  1097 ------YCESQF----------DHCEEKPCLNGATCRSYMGGFTCDCMPGYEGN------NCE-- 1137

  Fly  1614 RTVPEEEDKCKSDQDCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHAICNCAESYVW 1678
                .|.::|:|       :.||   || ..||:|                .||.||:|.     
Zfish  1138 ----REVNECQS-------HPCQ---NG-GTCIDL----------------VGHYICSCP----- 1166

  Fly  1679 NPVVSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICDAFT---------CPANSVCVARQ 1734
                                        |..||||..:...|..|         |..|..||.|.
Zfish  1167 ----------------------------PGTLGVLCEINEDDCATPSWPRGMPKCQNNGTCVDRV 1203

  Fly  1735 HQGRCDCLNGFVGNPNDRNGCQPAQKHHCRNHAECQ-ESEACIKDESTQTLGCRPACDTVKCGPR 1798
            ...||:|..||.|.                   .|: :...|:.:.      |.|: :::.|   
Zfish  1204 GGYRCNCPPGFTGE-------------------RCEGDINECLSNP------CNPS-NSLDC--- 1239

  Fly  1799 AVCVTNNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNHDC------PPSQMCNRMTHTC----- 1852
             :.:.|::  ||.|.||.........|:.|:|.||.....|      ||...|     ||     
Zfish  1240 -IQLPNDY--QCVCKPGFTGRGCQSRFSVCESQPCKNGGVCSLSGSSPPGYSC-----TCQLGYA 1296

  Fly  1853 ------FDVCDEESCGDNAICLAEDHRAVCQCPPGFKGDPLPEVACTKQG--GCAAGTCHPSAIC 1909
                  ...|.|..|.:...|......|.|.|..|| |.||    |..:.  ||::..||...:|
Zfish  1297 GSNCERSMNCKELPCYNGGSCTLTTRGARCTCIQGF-GGPL----CQHRSNDGCSSKPCHNGGLC 1356

  Fly  1910 EVTPEGPV--CKCPPLFVG---DAKSGGCRP-DGQCPNGDADCPANTICAGGVCQNPCDNACGSN 1968
            ......|.  |:|...:.|   :.|:|...| ...||..|....||    .|||...|     ::
Zfish  1357 TEETSYPFFHCQCTNGWKGKRCEQKTGSSAPLPSPCPIADCFSKAN----DGVCDKEC-----NS 1412

  Fly  1969 AECKVINRKPVCSCPLRFQPISDTAKDGCARTISKCLTDVDCGGALCYNGQCRIACRNSQ----- 2028
            .:|    |.....|.|...|.:..|...|.|              |..|.||...|.|::     
Zfish  1413 LDC----RWDGGDCSLAVNPWARCADPRCWR--------------LFNNSQCDEFCNNAECLFDN 1459

  Fly  2029 -DCSDGESCLKNVCVVACLDHSQCASGLACVEGHCTIGCRSNKECKQD 2075
             ||.:.|.....:....|.||        ..:|.|..|| :.:||..|
Zfish  1460 FDCINKEKVCNPIYEAYCTDH--------YADGLCDQGC-NTEECGWD 1498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 9/28 (32%)
EGF_CA 212..247 CDD:238011 16/34 (47%)
EGF_CA 255..>286 CDD:214542 15/30 (50%)
EGF_CA 298..331 CDD:238011 9/33 (27%)
EGF_CA 338..373 CDD:238011 4/35 (11%)
EGF_CA 413..456 CDD:238011 11/43 (26%)
EGF_CA 457..490 CDD:238011 12/34 (35%)
EGF_CA 497..>529 CDD:214542 12/33 (36%)
EGF_CA 580..>612 CDD:214542 13/31 (42%)
EGF_3 676..702 CDD:289699 10/25 (40%)
EGF_CA 1022..1056 CDD:214542 8/40 (20%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
notch3NP_571624.2 EGF_CA 97..131 CDD:238011 17/39 (44%)
EGF_CA 134..171 CDD:238011 18/41 (44%)
EGF_CA 212..247 CDD:238011 15/116 (13%)
EGF_CA 250..287 CDD:238011 14/39 (36%)
EGF_CA 290..325 CDD:238011 14/42 (33%)
EGF_CA 367..405 CDD:238011 18/41 (44%)
EGF_CA 407..443 CDD:238011 8/35 (23%)
EGF_CA 445..481 CDD:238011 16/43 (37%)
EGF_CA 483..519 CDD:238011 18/70 (26%)
EGF_CA 521..556 CDD:238011 14/45 (31%)
EGF_CA 560..594 CDD:238011 14/41 (34%)
EGF_CA 596..631 CDD:238011 9/41 (22%)
EGF_CA 634..668 CDD:238011 11/43 (26%)
EGF_CA 672..705 CDD:238011 11/55 (20%)
EGF_CA 708..744 CDD:238011 9/47 (19%)
EGF_CA 746..781 CDD:238011 10/46 (22%)
EGF_CA 824..860 CDD:238011 15/50 (30%)
EGF_CA 862..897 CDD:238011 11/35 (31%)
EGF_CA 902..936 CDD:238011 12/38 (32%)
EGF_CA 938..974 CDD:238011 14/75 (19%)
EGF_CA 977..1012 CDD:238011 9/61 (15%)
EGF_CA 1015..1050 CDD:238011 12/45 (27%)
EGF_CA 1103..1137 CDD:238011 11/39 (28%)
EGF_CA 1140..1175 CDD:238011 19/94 (20%)
EGF_CA <1193..1220 CDD:238011 11/45 (24%)
EGF_CA 1222..1260 CDD:238011 10/50 (20%)
Notch 1392..1423 CDD:278494 11/43 (26%)
Notch 1429..1462 CDD:278494 9/46 (20%)
Notch 1475..1502 CDD:278494 10/33 (30%)
NOD 1508..1559 CDD:284282
NODP 1577..1634 CDD:284987
ANKYR <1784..1896 CDD:223738
ANK <1784..1895 CDD:238125
ANK repeat 1791..1839 CDD:293786
ANK repeat 1841..1872 CDD:293786
Ank_5 1861..1916 CDD:290568
ANK 1869..1995 CDD:238125
ANK repeat 1875..1906 CDD:293786
ANK repeat 1908..1939 CDD:293786
Ank_2 1913..2005 CDD:289560
ANK 1936..2057 CDD:238125
ANK repeat 1941..1972 CDD:293786
ANK repeat 1974..2005 CDD:293786
Ank_2 1979..>2039 CDD:289560
Amelogenin 2232..2325 CDD:197891
DUF3454 2384..2445 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11833
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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