DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and PRX

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_870998.2	Gene:	PRX / 57716	HGNCID:	13797	Length:	1461	Species:	Homo sapiens

Alignment Length:	933	Identity:	199/933 - (21%)
Similarity:	340/933 - (36%)	Gaps:	224/933 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly 18709 YDKACVHHKCVDPCPGICGINADCRVHYHSPICYCISSHTGDPFTRCYETPKPVRPQIYDTPSPP 18773
            |:.|....:|.:|              |....|...:..|||...|      |.....|:...|.
Human    77 YEDALRLLQCAEP--------------YKVSFCLKRTVPTGDLALR------PGTVSGYEIKGPR 121

  Fly 18774 YPVA---IPDLVYVQQQQ--PGIVNIPSAPQPIYPTPQSPQYNVNYPSPQPANPQKPGVVNIPSV 18833
            ..||   |..|..|::::  ||.:.:|:...|:         :|.:..|:.:..::.........
Human   122 AKVAKLNIQSLSPVKKKKMVPGALGVPADLAPV---------DVEFSFPKFSRLRRGLKAEAVKG 177

  Fly 18834 PQPVYPSPQPPVYDVNYPTTPVSQHPGVVNIPSAPRLV----PPTSQRPVFITSPGNLSPTPQ-- 18892
            |.|..|:.:    .:..|...|.:   |.....|.||.    ||...:.....:.|.....||
Human   178 PVPAAPARR----RLQLPRLRVRE---VAEEAQAARLAAAAPPPRKAKVEAEVAAGARFTAPQVE 235

  Fly 18893 ------PGV-INIPSVSQPGYPTPQSPIYDA------NYPTTQSPIPQQPGV------VNIPSVP 18938
                  ||. :.:|.||.|    ..:|..:|      :.||.....|..|.|      :.:|.|.
Human   236 LVGPRLPGAEVGVPQVSAP----KAAPSAEAAGGFALHLPTLGLGAPAPPAVEAPAVGIQVPQVE 296

  Fly 18939 SPSYPAPNPPVNYPTQPS-PQIPVQPGVINIPSAPLPTTPPQHPPV----FIPSPESPSPAPKPG 18998
            .|:.|      :.||.|: |.:..:.|.:   |..:||.....|.|    .:|..|..:....|.
Human   297 LPALP------SLPTLPTLPCLETREGAV---SVVVPTLDVAAPTVGVDLALPGAEVEARGEAPE 352

  Fly 18999 V-INIPSVTHPEY-----------------------PTSQVPVYDVNYSTTPSPIPQKPGVV--- 19036
            | :.:|.::.|.:                       |..::|.:.::..   .|.|..|.||
Human   353 VALKMPRLSFPRFGARAKEVAEAKVAKVSPEARVKGPRLRMPTFGLSLL---EPRPAAPEVVESK 414

  Fly 19037 -NIPSAPQP-VHPAPNPPVHEFNYPTPPAV--PQQPGVLNIPSYPTPVAPTPQSPIYIPSQEQPK 19097
             .:|:...| :....:.|  |...|..|.|  |:.|.| .:|..|....|    .:.:|..|.||
Human   415 LKLPTIKMPSLGIGVSGP--EVKVPKGPEVKLPKAPEV-KLPKVPEAALP----EVRLPEVELPK 472

  Fly 19098 PTTRPSVINVPSVPQPAYPTPQAPVYDVNYP-TSPSVIPHQPGVVNIPSVPLP-----------A 19150
                .|.:.:|.||:.|.|..:.|  :|..| .|...:|..|.:. :|.|.||           .
Human   473 ----VSEMKLPKVPEMAVPEVRLP--EVELPKVSEMKLPKVPEMA-VPEVRLPEVQLLKVSEMKL 530

  Fly 19151 PPVKQRPVFVPSPVHP-TPAPQPGVVNIPSVAQPVHPTYQPPVVERPAIYDVYYPPP--PSRPGV 19212
            |.|.:  :.||....| ...|:...:.:|.|::...|..:.|.|:.|.:.::..|..  |..| .
Human   531 PKVPE--MAVPEVRLPEVQLPKVSEMKLPEVSEVAVPEVRLPEVQLPKVPEMKVPEMKLPKVP-E 592

  Fly 19213 INIPSPPRPVYPVPQQPIYVPAPVLHIPAPRPVIHNIPSVPQPTYPHRNPPIQDVTYPAPQPSPP 19277
            :.:|....|...:|:.| .:..|.:|:|..:     :|.||:...|....|  :|..| ..|...
Human   593 MKLPEMKLPEVQLPKVP-EMAVPDVHLPEVQ-----LPKVPEMKLPEMKLP--EVKLP-KVPEMA 648

  Fly 19278 VPGI----VNIPSLPQPVSTPTSGVINIPSQASPPISVPTPGIVNIPSIPQ--------PTPQRP 19330
            ||.:    |.:|.:|: :..|....:.:|....|.:.:|....:.:|.:|:        |..|.|
Human   649 VPDVHLPEVQLPKVPE-MKLPKMPEMAVPEVRLPEVQLPKVSEMKLPKVPEMAVPDVHLPEVQLP 712

  Fly 19331 SPGIINVPSVPQP---IPTAPSPGI--INIPSVPQPLPSPTPGVINIPQQPTPPPLVQQPGIINI 19390
            ....:.||.:..|   :|..|...:  :::|.|..|..|.    |.:|:...|          .:
Human   713 KVCEMKVPDMKLPEIKLPKVPEMAVPDVHLPEVQLPKVSE----IRLPEMQVP----------KV 763

  Fly 19391 PSVQQPSTPTTQHP-IQDVQYETQRPQPTPGV--------INIPSVSQPTYPTQ-KP-------S 19438
            |.|..|..|..:.| ..:||.:..:.:...|:        :.:|.:.:...|:: ||       |
Human   764 PDVHLPKAPEVKLPRAPEVQLKATKAEQAEGMEFGFKMPKMTMPKLGRAESPSRGKPGEAGAEVS 828

  Fly 19439 YQDTSYPTVQPKPPVSGIINIPSVPQPVPSL-TPGVINLPSE--------------PSYSAPIPK 19488
            .:..:.|.:||:......:.:||:..|...| .||.:.|..:              |..:|.:.:
Human   829 GKLVTLPCLQPEVDGEAHVGVPSLTLPSVELDLPGALGLQGQVPAAKMGKGERVEGPEVAAGVRE 893

  Fly 19489 PGIINVPSIPEPIPSIPQNPVQE 19511
            .| ..|||:....|.:|...::|
Human   894 VG-FRVPSVEIVTPQLPAVEIEE 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883	13/69 (19%)
		Med25_SD1	18795..18955	CDD:288132	37/184 (20%)
		MISS	19026..19258	CDD:292450	63/253 (25%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
PRX	NP_870998.2	PDZ	17..98	CDD:214570	6/34 (18%)
		Nuclear export signal. /evidence=ECO:0000305\|PubMed:24633211	70..84		2/6 (33%)
		Nuclear localization signal. /evidence=ECO:0000250	118..196		16/90 (18%)
		55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]-[AQKHRPE], that may have a tripeptide spacer of [LV]-P-[KER]	431..783		92/392 (23%)
		Cornifin	432..544	CDD:280537	35/127 (28%)
		Cornifin	583..704	CDD:280537	29/131 (22%)
		Cornifin	653..781	CDD:280537	29/142 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1318..1461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910