DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and ADGRB3

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001695.2	Gene:	ADGRB3 / 577	HGNCID:	945	Length:	1522	Species:	Homo sapiens

Alignment Length:	734	Identity:	152/734 - (20%)
Similarity:	206/734 - (28%)	Gaps:	280/734 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1645 CINLCSNVVCGPNELCKINPAGHAICNCAESYVWNPVVSSCEKPS-------LPDCTSDANCPDA 1702
            |..|...|:.|...:.::.|.....|      .|     :.|.|.       |.....|.:|.:.
Human    30 CSTLVKGVIYGSYSVSEMFPKNFTNC------TW-----TLENPDPTKYSIYLKFSKKDLSCSNF 83

  Fly  1703 SACRPDVLGVLKCVAICDAFTCPANSVCVARQH--QGRCDCLNGFVGNPNDRNGCQ--------- 1756
            |......          |.|:.......:.:.|  ...|:..|.||....|:|..|
Human    84 SLLAYQF----------DHFSHEKIKDLLRKNHSIMQLCNSKNAFVFLQYDKNFIQIRRVFPTNF 138

  Fly  1757 ------------------------PAQKHHCRNHAECQESEACIKDESTQTLGCRPACDTVKCGP 1797
                                    |:| ..|  |..|...|:|:|.|:.:|..|
Human   139 PGLQKKGEEDQKSFFEFLVLNKVSPSQ-FGC--HVLCTWLESCLKSENGRTESC----------- 189

  Fly  1798 RAVCVTNNHQAQCQCPP--GPFAGDPYD---------PFN----GCQSVPCVYNHDCPPSQMCNR 1847
             .:..|     :|.||.  |.:..|...         |.|    ||      ...:...:|:||
Human   190 -GIMYT-----KCTCPQHLGEWGIDDQSLILLNNVVLPLNEQTEGC------LTQELQTTQVCN- 241

  Fly  1848 MTHTCFDVCDEESCGDNAICLAEDHRAVCQCP--------PGFKGDPLPEVACTKQGG------- 1897
            :|........||      ..:..||....|.|        |..:.|....:|.|.:.|
Human   242 LTREAKRPPKEE------FGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWSQW 300

  Fly  1898 ------CAAGTCHPSAICEVTPEGPVCKCPPLFVGDAKSGGCRPDGQCPNGDADCPANTICAGGV 1956
                  |..|:...:..| |:|.|..|           ||..|....| |..|.||.:.:.....
Human   301 STCSVTCGQGSQVRTRTC-VSPYGTHC-----------SGPLRESRVC-NNTALCPVHGVWEEWS 352

  Fly  1957 CQNPCDNACGSNAECKVINRKPVCSCPLRFQPISDTAKDGCARTISKCLTDVDCGGALC-----Y 2016
            ..:.|...||..                             .||.::..|....||..|     :
Human   353 PWSLCSFTCGRG-----------------------------QRTRTRSCTPPQYGGRPCEGPETH 388

  Fly  2017 NGQCRIACRNSQDCS-DG---ESCLKNVCVVACLDHSQCASGLACVEGHCTIGCRSNKECKQDQS 2077
            :..|.||.     |. ||   |....:.|.|.|.:.:|..|      ..||.......||:...:
Human   389 HKPCNIAL-----CPVDGQWQEWSSWSQCSVTCSNGTQQRS------RQCTAAAHGGSECRGPWA 442

  Fly  2078 CIENKCLNPCQSANSCGPNALCSIDQHHSQC--SCPEGFEGNPTPEQGCVRVPAPCLASNQCPSG 2140
             ...:|.||     .|..|...:...|.|.|  ||..|:|......||.|
Human   443 -ESRECYNP-----ECTANGQWNQWGHWSGCSKSCDGGWERRIRTCQGAV--------------- 486

  Fly  2141 HMCIGNQCNLPCTKTASCAVGE---RCYQQVCRKVCYTSNNCLAGEICNSD--------RTCQPG 2194
              ..|.||.         ..||   ||.:|.| ...|        |||..|        ||  |.
Human   487 --ITGQQCE---------GTGEEVRRCNEQRC-PAPY--------EICPEDYLMSMVWKRT--PA 529

  Fly  2195 CD-SDADCPPTELCLTGKCKCATGFIGTPFGCSDIDECTEQPCHASARC-------------ENL 2245
            .| :...||......|.: :|:....|..|        .|||  :.|||             |:|
Human   530 GDLAFNQCPLNATGTTSR-RCSLSLHGVAF--------WEQP--SFARCISNEYRHLQHSIKEHL 583

  Fly  2246 PGTYRCVCPEGTVGDGYSQ 2264
            ....|.:     .|||.||
Human   584 AKGQRML-----AGDGMSQ 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011	9/45 (20%)
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
ADGRB3	NP_001695.2	RSN1_7TM	98..>175	CDD:330792	13/79 (16%)
		TSP1	296..343	CDD:214559	13/59 (22%)
		TSP1	348..398	CDD:214559	12/83 (14%)
		TSP1	403..452	CDD:214559	13/60 (22%)
		TSP1	458..508	CDD:214559	19/76 (25%)
		HormR	510..576	CDD:214468	21/86 (24%)
		GAIN	594..794	CDD:318649	3/4 (75%)
		GPS	816..867	CDD:197639
		7tmB2_BAI3	872..1164	CDD:320655
		TM helix 1	876..901	CDD:320655
		TM helix 2	911..933	CDD:320655
		TM helix 3	942..970	CDD:320655
		TM helix 4	980..1000	CDD:320655
		TM helix 5	1018..1047	CDD:320655
		TM helix 6	1094..1121	CDD:320655
		TM helix 7	1126..1151	CDD:320655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910