DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and PTK7

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001257327.1 Gene:PTK7 / 5754 HGNCID:9618 Length:1078 Species:Homo sapiens


Alignment Length:774 Identity:146/774 - (18%)
Similarity:226/774 - (29%) Gaps:307/774 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  6915 EQTTSSPSEVRTTIG--LEESTLPSRSTDRTSPSE-SPETPTTLPSDFITRPHSDQTTESTR--- 6973
            |:..|:|     |:|  :|:...|      |.|.. .|.|.|.:.  ||.:|.|....:..|   
Human     8 EKRPSAP-----TVGSAMEKKEFP------TPPGRVGPGTQTAIV--FIKQPSSQDALQGRRALL 59

  Fly  6974 ----DVP----------------TTRPF-EASTPSSASLETTVPSVTLETTTNVPIGSTG----- 7012
                :.|                |.|.| :.|:.|.|:::....|.|.:......:  ||     
Human    60 RCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDV--TGEEARS 122

  Fly  7013 ------------GQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRP 7065
                        |.|..:..:|.:|::                       |:|..||      |.
Human   123 ANASFNIKWIEAGPVVLKHPASEAEIQ-----------------------PQTQVTL------RC 158

  Fly  7066 HSDQTTESSRDVPTTQPFEASTP--------------RPVTLQTA-------------------- 7096
            |.|     ....||.|.|...||              |.:||:.|                    
Human   159 HID-----GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQAC 218

  Fly  7097 -----VLPVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPS------ 7150
                 .|.:..|:...|.:             :|.:| ...|.||:....:.:.:..||      
Human   219 SSQNFTLSIADESFARVVL-------------APQDV-VVARYEEAMFHCQFSAQPPPSLQWLFE 269

  Fly  7151 -ESPETPTTLPSDFTTRPHSDQTT---ESSRDVPTTQPFESSTPRPVTLETAVPPVTSETTTNVP 7211
             |:|.|..:.|      ||..:.|   ..|..:...:|..:...|.:......||:..|.|.:: 
Human   270 DETPITNRSRP------PHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHL- 327

  Fly  7212 IGSTGGQVTEQTTPSPSEVRTTIRIEESTFPSRSTDRTT--PSESPETPTTLPSDFTTRPHSDQT 7274
                            :|:......|...|.:.|.:|.|  |      |..||.......|:...
Human   328 ----------------AEIEDMPLFEPRVFTAGSEERVTCLP------PKGLPEPSVWWEHAGVR 370

  Fly  7275 TESTRDVPT-TRPFESSTPRPVTLEIAVPPVTSETTTNVAIGSTGGQVTEQTTSSPSEVRTTIRV 7338
                  :|| .|.::...      |:.:        .|:| .|..|..|....:...:.|..:.:
Human   371 ------LPTHGRVYQKGH------ELVL--------ANIA-ESDAGVYTCHAANLAGQRRQDVNI 414

  Fly  7339 EESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRP-----FEASTPSPAS 7398
            ..:|:||                     :..:|...|..|.       :|     ...:||.|..
Human   415 TVATVPS---------------------WLKKPQDSQLEEG-------KPGYLDCLTQATPKPTV 451

  Fly  7399 L--------------------ETTVPSVTLETTT------SVPMGSTGGQVTGQT------TAPP 7431
            :                    ...:.||.:...|      |.|.||...|...|.      |.||
Human   452 VWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPP 516

  Fly  7432 SEVRTTIRVEESTLPSRSTDRTPPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTP 7496
            ...:.....:|:|:|..:|.|..|:...|.     :|.::.|                  |..|.
Human   517 QPQQCMEFDKEATVPCSATGREKPTIKWER-----ADGSSLP------------------EWVTD 558

  Fly  7497 RPVTLEIAVPPVTSETTTNVP-IGSTG--GQVTGQTTATPSEVRTTIGVEESTLPSRST 7552
            ...||..|  .||.:...|.. |.|.|  ||:......|.: |..|..||    |.|:|
Human   559 NAGTLHFA--RVTRDDAGNYTCIASNGPQGQIRAHVQLTVA-VFITFKVE----PERTT 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395 25/110 (23%)
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572 7/27 (26%)
DUF4758 6866..7045 CDD:292572 32/173 (18%)
DUF4758 6968..7179 CDD:292572 51/300 (17%)
DUF4696 7024..7569 CDD:292395 115/621 (19%)
DUF4758 7172..7383 CDD:292572 35/216 (16%)
DUF4696 7330..7964 CDD:292395 53/263 (20%)
DUF4758 7400..7587 CDD:292572 42/168 (25%)
DUF4758 7538..7707 CDD:292572 6/15 (40%)
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
PTK7NP_001257327.1 IG_like 46..120 CDD:214653 14/75 (19%)
IGc2 53..113 CDD:197706 10/59 (17%)
Ig2_PTK7 154..230 CDD:143237 16/86 (19%)
IG_like 239..>309 CDD:214653 16/76 (21%)
Ig 250..310 CDD:143165 12/65 (18%)
IG 348..416 CDD:214652 17/94 (18%)
IGc2 348..406 CDD:197706 16/84 (19%)
I-set 420..506 CDD:254352 17/113 (15%)
Ig 422..506 CDD:299845 15/90 (17%)
I-set 511..596 CDD:254352 25/109 (23%)
IGc2 528..582 CDD:197706 17/78 (22%)
IG_like 606..689 CDD:214653 3/5 (60%)
IGc2 613..677 CDD:197706
PTK_CCK4 798..1071 CDD:133178
STYKc 809..1069 CDD:214568
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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