DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and bcar1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_021323361.1	Gene:	bcar1 / 568309	ZFINID:	ZDB-GENE-030131-2774	Length:	961	Species:	Danio rerio

Alignment Length:	485	Identity:	117/485 - (24%)
Similarity:	156/485 - (32%)	Gaps:	185/485 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly 18785 QQQQPGIVNIPSAPQPIYPTPQS--------PQYNVNYPSPQP---ANPQKP-GVVNIPSVPQPV 18837
            |||...:.|.||..|.:...|||        .||...:|:..|   ||...| ||..:|
Zfish   114 QQQLQQLANQPSPTQSLINLPQSAYNKIPPAAQYTAMHPAFTPSGSANSTNPDGVYMLP------ 172

  Fly 18838 YPSPQPPVYDVNYPTTPVSQHPGVVNIPSAPRLVPPTSQRPVFITSPGNLSPTPQPGVINIPSVS 18902
             ||....:|.|                ||.|                    |||||
Zfish   173 -PSHGSSLYQV----------------PSGP--------------------PTPQP--------- 191

  Fly 18903 QPGYPTPQSPIYDANYPTTQSPIPQQPGVVNIPSVPSPSYPAPNPPVNYPTQPSPQIPVQPGVIN 18967
            ||..|..........||.|...:.|.|                 |.:|.|.|...|:|...|. .
Zfish   192 QPKAPALAKKQTHVQYPPTTQDVYQVP-----------------PSINAPGQDIYQVPPAAGG-Q 238

  Fly 18968 IPSAPLPTTPP---------QHPPVFIPSPESPSPAPKPGVINIPSVTHPEYPTSQVPVYDVNYS 19023
            .|...:...||         |.||....|.:||.|.   |.:.:|:      ...||.|||...:
Zfish   239 CPGQDVYQVPPSVNQTQDVYQIPPSLDRSWDSPKPM---GKVVVPT------RVGQVYVYDTGKN 294

  Fly 19024 -----TTPSPIPQKPGVVNIPSAPQPVHPAPNPPVHEFNYPTPPAVPQQPGVLNIPS----YPTP 19079
                 ..|..:|....:.::|       |.....:.:. |.|||...:.|     ||    |.||
Zfish   295 EQDEYDVPRHLPPSQDIYDVP-------PTRTQYIQQV-YDTPPMAMKGP-----PSGQEIYDTP 346

  Fly 19080 VAPTPQSPIYIPSQEQPKPTTRPSVINVPSVPQPAYPTPQAPVYDVNYPTSPSVIPH-------- 19136
                       ||.::.:...:.:|.::|  |..:...|..|:.:..|    .|.||
Zfish   347 -----------PSVDKSQLHYQQTVYDIP--PSVSKDVPDGPIREETY----DVPPHFAKMKSLE 394

  Fly 19137 ---QPGVVNIPSVPLPAPPVKQRPVFVPSPVHPTPAPQ---------PGVVNIPSV-----AQPV 19184
               |..:..||..  |.||       :|..|:..|.||         ..:.:||:.     .|..
Zfish   395 NQNQAYLSQIPGG--PEPP-------IPEDVYDVPPPQLIGKRQPEGQEIYDIPASLRKGGPQDH 450

  Fly 19185 HPT--YQPPVVERPA-------IYDVYYPP 19205
            |||  |..| .||||       :|||  ||
Zfish   451 HPTDVYDFP-RERPAGEDSGDYVYDV--PP 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883	19/58 (33%)
		Med25_SD1	18795..18955	CDD:288132	39/171 (23%)
		MISS	19026..19258	CDD:292450	53/218 (24%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
bcar1	XP_021323361.1	SH3_BCAR1	46..112	CDD:212934
		EBV-NA3	<123..254	CDD:332796	46/200 (23%)
		Serine_rich_BCAR1	530..686	CDD:211406
		PLC-beta_C	<764..815	CDD:312287
		FAT-like_CAS_C	827..958	CDD:325950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910