DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and Notch3

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_064472.3 Gene:Notch3 / 56761 RGDID:620761 Length:2319 Species:Rattus norvegicus


Alignment Length:1879 Identity:497/1879 - (26%)
Similarity:702/1879 - (37%) Gaps:558/1879 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LQLFNLSKLCDGTQDCFLGADELSKELKCTNDCDKDGTKCTH------GACLNGVCHCNDGYGGC 123
            |.|..|:.|......|..|:       .|.|     |.:|||      .|||     |..|:.|.
  Rat    29 LLLLLLAGLGAAAPPCLDGS-------PCAN-----GGRCTHQQPSREAACL-----CLPGWVGE 76

  Fly   124 NCVDKDENECKQRPCDVFAHCTNT----LGSFTCTCFPGYRGNGFHCEDIDECQ--DPAIAARCV 182
            .|  :.|:.|...||.....|.::    :..|:|.|..|:||        .:|.  ||..::.|.
  Rat    77 RC--QLEDPCHSGPCAGRGVCQSSVVAGVARFSCRCLRGFRG--------PDCSLPDPCFSSPCA 131

  Fly   183 ENAEC-CNLPAHFLCKCKDGYEGDGEVLC-TDVDECRNPENCGPNALCTNTPGNYTCSCPDGYVG 245
            ..|.| ......:.|.|..||:|..   | :|:||||...:|.....|.||||::.|.||.||.|
  Rat   132 HGAPCSVGSDGRYACACPPGYQGRN---CRSDIDECRAGASCRHGGTCINTPGSFHCLCPLGYTG 193

  Fly   246 -----------NNPYREG--CQDVDECSYPNVCGP---------------------GAICTNLEG 276
                       .:|.|.|  |:...:.:|...|.|                     |..|.:...
  Rat   194 LLCENPIVPCAPSPCRNGGTCRQSSDVTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN 258

  Fly   277 SYRCDCPPGYDGDGRSESGCVDQDECARTP--CGRNADCLNTDGSFRCLCPDGYSGDPMNGCEDV 339
            :|.|.|||.:.|...:|    |.|||...|  |.....|.|..|...|:|.:|::|:..:  :::
  Rat   259 TYNCQCPPEWTGQFCTE----DVDECQLQPNACHNGGTCFNLLGGHSCVCVNGWTGESCS--QNI 317

  Fly   340 DECATNNPCGLGAECVNLGGSFQCRCPSG----------FVLEHDPHADQL--PQPLNTQQL--- 389
            |:||| ..|..||.|.:...||.|.||.|          ..:.:..|.|.:  ..|::.:.:   
  Rat   318 DDCAT-AVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVSGRAICTC 381

  Fly   390 --GYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGY 452
              |:..||.|              .|:|||:  .|...|....:|:|..||:.|.|..|:.|.  
  Rat   382 PPGFTGGACD--------------QDVDECS--IGANPCEHLGRCVNTQGSFLCQCGRGYTGP-- 428

  Fly   453 LHCE-NINECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGC-VDIDECTALDKPCGQHAVCE 515
             .|| ::|||...||...|.|.|.:|.|.|.|...:||   ..| ||||||.:  .||....||:
  Rat   429 -RCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTG---TFCEVDIDECQS--SPCVNGGVCK 487

  Fly   516 NTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIEN----QCFCLDGFEPIGS 576
            :.|.|::|.||.|:.|.     .| |:||: .|:|. .|.|.|:|::.    :|.|.:|||  |:
  Rat   488 DRVNGFSCTCPSGFSGS-----TC-QLDVD-ECAST-PCRNGAKCVDQPDGYECRCAEGFE--GT 542

  Fly   577 SCV-DIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCEDVR---CGAHAYCK 637
            .|. ::|:|  ..:.| .|.:|::...|:.|.|..||.|    :.|:...::.|   |.....|.
  Rat   543 LCERNVDDC--SPDPC-HHGRCVDGIASFSCACAPGYTG----IRCESQVDECRSQPCRYGGKCL 600

  Fly   638 PDQNEAYCVCEDGWTYNPSDVAAGC-VDIDECDVMHGPFGSCGQNATCTNSAGGFTCACPPGFSG 701
            ...::..|.|..|.|      ...| |:||:|......||      .|.:....:.|.|.|||:|
  Rat   601 DLVDKYLCRCPPGTT------GVNCEVNIDDCASNPCTFG------VCRDGINRYDCVCQPGFTG 653

  Fly   702 DPHSKC-VDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANEDCP 765
               ..| |:::||  .:|.||.|..||: ...|:.|.||..::    |.: |:|:          
  Rat   654 ---PLCNVEINEC--ASSPCGEGGSCVD-GENGFHCLCPPGSL----PPL-CLPV---------- 697

  Fly   766 GNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTG---NSALAGGC 827
                                  .|||....| :|..|..|.|..||:|.||::|   :.:||.  
  Rat   698 ----------------------NHPCAHKPC-SHGVCHDAPGGFQCVCEPGWSGPRCSQSLAP-- 737

  Fly   828 NDIDECRANPCAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQDS 892
               |.|.:.||.....|::...|:.|.|..|..|..            |...:|| |...|....
  Rat   738 ---DACESQPCQAGGTCTSDGIGFHCTCAPGFQGHQ------------CEVLSPC-TPSLCEHGG 786

  Fly   893 YTGN-----SVCICRQGYERNSENGQC-QDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHN 951
            :..:     :||.|..|:    :..:| ||||||:   |...||.:..|.|||||:.|.|..|:.
  Rat   787 HCESDPDQLTVCSCPPGW----QGPRCQQDVDECA---GASPCGPHGTCTNLPGSFRCICHGGYT 844

  Fly   952 GNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAECISIAGGVSYCACPKGYQTQP 1016
            | ||...:|                :.|..:.|.:|.:|..|....|       |:|..|:   .
  Rat   845 G-PFCDQDI----------------DDCDPNPCLNGGSCQDGVGSFS-------CSCLSGF---A 882

  Fly  1017 DGSCV-DVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRKCAADRECAAN 1080
            ...|. |||||.   :..|..|. |.:...|::|.||.||.|           ..|..|....:.
  Rat   883 GPRCARDVDECL---SSPCGPGT-CTDHVASFTCTCPPGYGG-----------FHCETDLLDCSP 932

  Fly  1081 EKCIQPGECV---------CPPPYFLDPQDNNKCK---SPCERFPCGINAKCTPSDPP-QCMCEA 1132
            ..|...|.||         |.|.|     ....|:   .||...||.....|.|:... :|.|..
  Rat   933 SSCFNGGTCVDGVNSFSCLCRPGY-----TGTHCQYKVDPCFSRPCLHGGICNPTHSGFECTCRE 992

  Fly  1133 GFKGDPLLGCTDE-DECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLS 1196
            ||.|:.   |.:. |.||..||..|..|| :.|.| |:||.:::| |.   |...|         
  Rat   993 GFTGNQ---CQNPVDWCSQAPCQNGGRCV-QTGAY-CICPPEWSG-PL---CDIPS--------- 1039

  Fly  1197 NDDCASNLACLEGSC-VSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQDVICGD 1260
                   |.|.|.:. :......||.:...|..:.|:.:|.|..|.:.:.....|..|....|..
  Rat  1040 -------LPCTEAAAHMGVRLEQLCQAGGQCIDKDHSHYCVCPEGRMGSHCEQEVDPCTAQPCQH 1097

  Fly  1261 GALCIPTSEGPTCKCPQGQLGNPFPGGSC--STDQCSAARPCGERQICINGRCKERCEGVVCGIG 1323
            |..|.....|..|:||.|     :.|.||  ..|:| |::||                       
  Rat  1098 GGTCRGYMGGYVCECPAG-----YSGDSCEDDVDEC-ASQPC----------------------- 1133

  Fly  1324 ATCDRNNGKCI---------CEPNFVGNPDLICMPPIEQAKCSPG--------CGENAHCEYGLG 1371
                :|.|.||         |.|..:|   ::|  .|.:..|.||        |..|..|...:|
  Rat  1134 ----QNGGSCIDLVAHYLCSCPPGTLG---VLC--EINEDDCGPGPSLDSGLRCLHNGTCVDLVG 1189

  Fly  1372 QSRCACNPGTFGNPYEGCGAQSK-NVCQPNSC--GPNAEC-RAVGNHISCLCPQGFSGNPYIGCQ 1432
            ..||.|.||     |.|...::. |.|:|.:|  ....:| :..|.|..|:|..||:|.   .||
  Rat  1190 GFRCNCPPG-----YTGLHCEADINECRPGTCHAAHTRDCLQDPGGHFRCICLPGFTGP---RCQ 1246

  Fly  1433 D-VDECANKPCGLNAAC---LNRAGG--FECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERV 1491
            . :..|.::||.....|   |.|.||  |.|.|:           ||.....|:...: .|.| :
  Rat  1247 TALFPCESQPCQHGGQCRPSLGRGGGLTFTCHCV-----------QPFWGLRCERVAR-SCRE-L 1298

  Fly  1492 ECPEGYSCQKGQCKNLCSQASCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCGND---ADC 1553
            :||.|..||         |.:.|||       |.||.|..| |..:|...|..|.....   ..|
  Rat  1299 QCPVGIPCQ---------QTARGPR-------CACPPGLSG-PSCRVSRASPSGATNTSCAATPC 1346

  Fly  1554 LHSEICFQLGKGLRKCVDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPE 1618
            ||.              .:|..:|..|         ...|:|:.| :|.|.     |:.....||
  Rat  1347 LHG--------------GSCLPVQSVP---------FFRCVCAPG-WGGPR-----CETPSAAPE 1382

  Fly  1619 --EEDKCKSDQDCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHAICNCAESYVWNPV 1681
              ||.:|..       ..|||. .|.:.|...|::..||                      |:. 
  Rat  1383 VPEEPRCPR-------AACQAK-RGDQNCDRECNSPGCG----------------------WDG- 1416

  Fly  1682 VSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICDAFTCPA---NSVCVARQHQGRC---- 1739
                     .||:.:.:.|...               |:|..|..   ||.|........|    
  Rat  1417 ---------GDCSLNVDDPWRQ---------------CEALQCWRLFNNSRCDPACSSPACLYDN 1457

  Fly  1740 -DCLNGFVGNPNDRNGCQPAQKHHCRNH-AECQESEACIKDESTQTLGCRPACDTVKCG 1796
             ||.:|    ..||. |.|..|.:|.:| |:.:               |...|:|.:||
  Rat  1458 FDCYSG----GRDRT-CNPVYKKYCADHFADGR---------------CDQGCNTEECG 1496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 9/32 (28%)
EGF_CA 212..247 CDD:238011 17/45 (38%)
EGF_CA 255..>286 CDD:214542 10/51 (20%)
EGF_CA 298..331 CDD:238011 12/34 (35%)
EGF_CA 338..373 CDD:238011 14/44 (32%)
EGF_CA 413..456 CDD:238011 14/42 (33%)
EGF_CA 457..490 CDD:238011 13/32 (41%)
EGF_CA 497..>529 CDD:214542 14/31 (45%)
EGF_CA 580..>612 CDD:214542 8/31 (26%)
EGF_3 676..702 CDD:289699 7/25 (28%)
EGF_CA 1022..1056 CDD:214542 13/33 (39%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Notch3NP_064472.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
EGF_CA 160..197 CDD:238011 17/36 (47%)
EGF_CA 238..274 CDD:238011 8/35 (23%)
EGF_CA 276..313 CDD:238011 13/36 (36%)
EGF_CA 316..351 CDD:238011 14/35 (40%)
EGF_CA 393..431 CDD:238011 14/42 (33%)
EGF_CA 433..469 CDD:238011 14/38 (37%)
EGF_CA 471..507 CDD:238011 17/43 (40%)
EGF_CA 509..545 CDD:238011 14/39 (36%)
EGF_CA 547..582 CDD:238011 11/41 (27%)
EGF_CA 585..620 CDD:238011 7/40 (18%)
EGF_CA 622..656 CDD:238011 12/42 (29%)
EGF_CA 660..>688 CDD:238011 12/30 (40%)
EGF_CA 698..731 CDD:238011 14/33 (42%)
EGF_CA 738..772 CDD:238011 10/45 (22%)
EGF_CA 812..848 CDD:238011 19/39 (49%)
EGF_CA 851..886 CDD:238011 10/60 (17%)
EGF_CA 889..924 CDD:238011 15/49 (31%)
EGF_CA 931..962 CDD:238011 7/35 (20%)
EGF_CA 965..1000 CDD:238011 11/37 (30%)
EGF_CA 1087..1122 CDD:238011 12/39 (31%)
EGF_CA 1124..1160 CDD:238011 13/68 (19%)
EGF_CA 1173..1205 CDD:238011 11/36 (31%)
NL 1382..1419 CDD:197463 13/76 (17%)
LNR 1 1389..1429 13/79 (16%)
NL 1423..1460 CDD:197463 8/51 (16%)
LNR 2 1430..1467 10/40 (25%)
LNR 3 1469..1507 11/43 (26%)
Notch 1473..1502 CDD:395019 9/39 (23%)
NOD 1510..1562 CDD:399654
NODP 1580..1639 CDD:400155
JMTM_Notch3 1620..1711 CDD:411987
ANKYR <1779..1895 CDD:223738
ANK repeat 1790..1838 CDD:293786
ANK repeat 1840..1871 CDD:293786
ANK 1 1840..1869
ANKYR 1860..2026 CDD:223738
ANK repeat 1873..1905 CDD:293786
ANK 2 1873..1903
ANK repeat 1907..1938 CDD:293786
ANK 3 1907..1936
ANK repeat 1940..1971 CDD:293786
ANK 4 1940..1969
ANK repeat 1973..2004 CDD:293786
ANK 5 1973..2002
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2026..2046
PHA03247 <2029..2316 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2059..2129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2197..2319
DUF3454 2213..2269 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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