DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and crebbpa

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_005161826.1 Gene:crebbpa / 566841 ZFINID:ZDB-GENE-050208-439 Length:2350 Species:Danio rerio


Alignment Length:2455 Identity:427/2455 - (17%)
Similarity:686/2455 - (27%) Gaps:876/2455 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  5605 VPTTRPFEASTPSPASLE----TTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVRTTIR---- 5661
            :|.:.|     |.|..|:    |:||::..:...:|.:.:..|..||.|..|  |.|..|:    
Zfish   264 LPNSLP-----PFPTDLKGATVTSVPNMPQQQQVSVGMVAGQGVSTGPTADP--EKRKLIQQQLV 321

  Fly  5662 -----------------VEESTLPSRST-----DRTTPSESPETPTILPSDSTTRTYSDQTTEST 5704
                             |....||...|     :..|..::.::..:....|:.:..|.....:.
Zfish   322 LLLHAHKCQRREQANGDVRACALPHCRTMKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKNCTR 386

  Fly  5705 RDVPTTRPFEAS-------------TPSPASLETTVPSVTLETTTNVPIGSTGGQVTGQTTATPS 5756
            .|.|...|.:.:             :|..|||:|             ||||.|   |||.||   
Zfish   387 HDCPVCLPLKNASENANKHNQQPMLSPPNASLQT-------------PIGSVG---TGQQTA--- 432

  Fly  5757 EVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPS 5821
                                      |..|::.|.|    |.|.:...:...:|.:......|.|
Zfish   433 --------------------------PALPSSTPID----PSSMRRAYAALGLPYSNQNPTQTQS 467

  Fly  5822 PASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRTSPSESPE 5886
            |             |.|..|     ||.|.||....              |.||.:.....:.  
Zfish   468 P-------------TQTQGP-----GQTTAQTPHQQ--------------PMRSINALGGGQL-- 498

  Fly  5887 TPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPI---GSTG 5948
            .|..:|           |:|..:.:|               :.|:||     |.|.|:   |||.
Zfish   499 NPIGVP-----------TSEQAKLLP---------------DGTMPS-----TLNNPVMPDGSTV 532

  Fly  5949 GQVTGQTTAPPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEQTTESTRDV 6013
            |.::...||.|                                 |.:..:.:...|..|:..|:.
Zfish   533 GNLSNLPTAAP---------------------------------LSATGVRKAWHEHVTQDLRNH 564

  Fly  6014 PTTRPFEA--STPSPASLK----------------TTVPSVTS---------------------- 6038
            ...:..:|  .||.||:||                ....|..|                      
Zfish   565 LVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRDEYYHFLAEKIYKIQKELEEK 629

  Fly  6039 -------EATTNVPIGSTGQR---------IGTTPSESPETPTTLPSDFTTR--------PHSEK 6079
                   :......:.:|||:         :|..|...|.....:|:....|        |.|  
Zfish   630 RRSRLQKQIINQTSMTATGQQPSALNQPNVMGPRPQNGPVPMPNVPNQILNRMQVSQGMNPFS-- 692

  Fly  6080 TTESTRDVPTTR-PFETSTPSPASLE----TTVPSVTLETTTNVP----IGSTGGQVTEQTTSSP 6135
               :..:||.:: |..|...||.:.:    ..||::.:..|...|    :|:.||.:..|     
Zfish   693 ---AMSNVPMSQAPMGTRAASPINHQQINMNQVPTMNMSPTRIAPTQGMLGAHGGNMVTQ----- 749

  Fly  6136 SEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPS 6200
                                  ||::        :.|.|:|....|| :|.:|...:|   ::.:
Zfish   750 ----------------------TPNQ--------TQFMTQPPFPATT-NTMNVNMGQP---NSQT 780

  Fly  6201 PASLETTVPSVTSETTTNVPIGSTG--GQVTGQTTAPPSEVRTTIGVEESTLPSRSTDRTSPSES 6263
            |.|.:        :...|:|:.:.|  |...|..|.|.:.:|.|                     
Zfish   781 PVSQQ--------QPNANLPLNALGPLGPALGCPTPPQAPLRAT--------------------- 816

  Fly  6264 PETPTTLPSDFITRPHSEQTTESTRDVPTTRPFEASTPSPASLKTTVPSVTSEATTNVPIGSTGG 6328
                          |....|..||.::|..  .:.|||:||..:.|.|.:.::|...:|     |
Zfish   817 --------------PPPNATAASTTNLPAA--LQPSTPTPAPAQATPPHMQTQAELPIP-----G 860

  Fly  6329 QVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSEKTTESTRDVP 6393
            |....|.:..:.|.|......:.|.|:   ...|...|....|...|:.....:|.:||:..|..
Zfish   861 QQHPGTPTGENRVPTPASAASTELHSQ---HAVPDVPPNDTKTEEQDYDMAVKTEPSTETEEDTG 922

  Fly  6394 T----TRPFETSTPSPASLETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTTI----RVE 6450
            :    ....|.|......:||......|:|.|.....|   :..|..::.||:.|..|    .:.
Zfish   923 SLLVKKEEQEGSEAKQEPMETEDKKTDLKTETKEEDES---KTNGTASSSPSQSRRKIFKPEELR 984

  Fly  6451 ESTLPS-----RSTDRTSPSESPETPTTL--PS--DFITRPHSEKTTESTRDV------------ 6494
            ::.:|:     |....:.|...|..|..|  |.  |.:..|....|.:...|.            
Zfish   985 QALMPTLESLYRQDPESLPFRQPVDPILLGIPDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDD 1049

  Fly  6495 ----------------------------------PTT--------RPFEASTPSSASSGNN-CSI 6516
                                              |..        |.:|.|..:....|.. |:|
Zfish  1050 VWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVMQGLGYCCGRKYEFSPQTLCCYGKQLCTI 1114

  Fly  6517 -------SYFRNHYKCSNRFNR-SADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPF 6573
                   ||...::.|...||. ..|..|..:.|..|      .|....:|......|.....||
Zfish  1115 PRDGTYYSYQNRYHFCEKCFNEIQGDSVTLGDDPAQP------QTMISKDQFERKKNDTLDPEPF 1173

  Fly  6574 EASTPSPASL--------ETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVR-----TTIRVE 6625
            .........:        |...||               |.:........::.|     |..|::
Zfish  1174 VECKDCGRKMHQICVLHYEVIWPS---------------GFICDNCLKKSAKSRKENKFTAKRLQ 1223

  Fly  6626 ESTLPSRSTDRTTP----SESPETPTILPSDFTTRPHSDQTTE-----STRDVPTTRPFEASTPR 6681
            .:.|.:...||...    ...||...:......:   ||:|.|     ..:.|.|....||...|
Zfish  1224 STRLGTYIEDRVNKYLKRQNHPEAGEVFVRVVAS---SDKTVEVKPGMKAKFVDTGEMMEAFPYR 1285

  Fly  6682 PVTLETAVPSVTLETTTNVPIGSTGGQVTGQTTATPSEVRTTIRVEESTLPS------------- 6733
            ...|      ...|....|.:...|..|  |...:......|.||..|.|.|             
Zfish  1286 TKAL------FAFEEIDGVDVCFFGMHV--QEYGSDCPFPNTRRVYISYLDSIHFFKPRMLRTAV 1342

  Fly  6734 ------------RSTDRTT-------PSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEA 6779
                        :.....|       |||.        .|:....|               |.:.
Zfish  1343 YHEILIGYLEYVKKLGYVTAHIWACPPSEG--------DDYIFHCH---------------PADQ 1384

  Fly  6780 STPSPASLETTVPSVTSETTTNVPIGSTGG---QVTEQTTSSPSEVRTTIG------LEES--TL 6833
            ..|.|..|:.....:..:......:.....   |.||...:|.:|:....|      ||||  .|
Zfish  1385 KIPKPKRLQEWYRKMLDKAFAERILHDYKDIFKQATEDRLTSANELPYFEGDFWPNVLEESIKEL 1449

  Fly  6834 PSRSTDRTSPSESP--ETPTTLPSDF--ITRPHSDQTTESTRDVPTTRPFEASTPSPAS------ 6888
            .....:|.....:.  |||...|.|.  ..:.::.:|.::...:......:...|:.|:      
Zfish  1450 EQEEEERKKEENTAACETPEGTPGDSKNAKKKNNKKTNKNKSSLSRANKKKPGMPNVANDLSQKL 1514

  Fly  6889 ---------------------LETTVPSVTSETTTNVPI-------------------------G 6907
                                 :.:.:|.:.|:...|..:                         .
Zfish  1515 YATMEKHKEVFFVIHLHSGPIVNSLLPILDSDPLLNCDLMDGRDAFLTLARDKHWEFSSLRRCKW 1579

  Fly  6908 STGGQVTEQTTSSPSE----------------------------------------VRTTIGLEE 6932
            ||...:.|........                                        |:..:||::
Zfish  1580 STMCMLVELHNQGQDRFVYTCNECKHHVETRWHCTVCEDFDLCINCYNAKGHEHQMVKWGLGLDD 1644

  Fly  6933 STLPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSSASLETTVPS 6997
            .:.........||.||            .|....:..:|.......|....|.||...::..|  
Zfish  1645 DSSSQSGEASKSPQES------------RRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVV-- 1695

  Fly  6998 VTLETTTNVPIGSTGG---------------------------------QVTEQTTSSPSEVRTT 7029
               :.|......:.||                                 ::.:|......:....
Zfish  1696 ---QHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQLQHRLQQAQM 1757

  Fly  7030 IRVEESTLPSRSTDRTTP----SESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFEASTPRP 7090
            :|...:|:..|:..::.|    |.:|.|||:     ..:|::.||       |...|.:.:||..
Zfish  1758 MRRRMATMQGRAMPQSLPSPPASTAPSTPTS-----HQQPNTPQT-------PQPLPNQPTTPNA 1810

  Fly  7091 VTLQTAVLPVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESP-- 7153
            |        |.|.|..|.|  ..|..:.:.:...|....:.:..::|.||.....:..|.:.|  
Zfish  1811 V--------VMSPTYPNTP--RNGQPLPQASQGKPGPQASPLHQQQSPLPQPPQQQPPPQQPPQQ 1865

  Fly  7154 -ETPTTLPSDFTTRPHSDQTTESSRDVPTTQ---PFESSTPR-------PVTLETAVPPVTSETT 7207
             :.|.  |.......|.:...::.::...|.   |.....||       |:.|   |.|...:..
Zfish  1866 QQQPP--PMAVKMARHIEMVAQAQQNYRMTMNGLPMNHQQPRMPGAMQPPMQL---VGPRGQQVM 1925

  Fly  7208 TNVPIGSTGG-----------QVTEQTTPSPSEVRTTIRIEESTFPSRSTD--RTTPSESPE--- 7256
            ..:|.|...|           ||.:||...|   ::|:.|:....|.:...  ...|::.|.   
Zfish  1926 QPMPQGQWPGGAQPSMPAAQQQVAQQTPQGP---QSTLPIQRPAMPQQVAQPRMMVPTQGPRPQA 1987

  Fly  7257 -------TPTTLPSDFTT--RPHSDQTTESTRDVPTTRP-------------FESSTP---RPVT 7296
                   .|..|.....|  .|.|.|..:...::..:.|             :.:|.|   :|..
Zfish  1988 PQRAAGIAPNALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYHASQPQQQQPQQ 2052

  Fly  7297 LEIAVPPVTSETTTNVAIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPT 7361
            ...|..|.........|: ...|...:|....|     |.:...:..|........|:.:|:...
Zfish  2053 GIHAAQPAMQNMAAMQAV-PRPGMAPQQQQQQP-----TPQGMAALGPQGQLMNPAPANNPQLQE 2111

  Fly  7362 TLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTSVPMGSTGGQVTGQ 7426
            .............|..:....:|..   ....|......|....:.:: ...:.|..|||.: ||
Zfish  2112 MYRRQLLRHQQQQQQQQQQGGMPQA---HGQFPQAQGTATNYTQLRMQ-QQQLAMQGTGGPM-GQ 2171

  Fly  7427 TTAPPS------------EVRTTIRVEESTLPSRSTDRTPP-----SESPETPTT---------- 7464
              .||.            ..|..:.:::..||.:.....||     ..||.:|.|          
Zfish  2172 --LPPMAQMAMDGTPNLLHQRNNLLLQQQQLPQQQVVLKPPMGSQAQPSPMSPQTHLLSGQPQGA 2234

  Fly  7465 -LPSDFTTRPHSDQT-----TESSRDVPTTQPFESSTPRPVTLEIAVPPVTSETTTNVPIGSTGG 7523
             ||........|:|.     .:|.|. |:.||...|:|.|     .|.|..|  ..:|| ..||.
Zfish  2235 HLPGQPMANALSNQVCSPGPVQSPRP-PSQQPPPHSSPSP-----HVQPQPS--PQHVP-SHTGS 2290

  Fly  7524 QVTGQTTATPSEV-RTTIGVEEST--LPSRSTDRTTPSESPETPTTLPSD 7570
            ...|.||..|..: :..:|..|.:  ||..:    ||:..     .||||
Zfish  2291 PHPGLTTPMPGSMDQGHLGTPEQSAMLPQLN----TPNRG-----GLPSD 2331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572 12/48 (25%)
DUF4758 5700..5877 CDD:292572 39/189 (21%)
DUF4696 5756..6396 CDD:292395 126/721 (17%)
DUF4758 5802..5979 CDD:292572 33/179 (18%)
DUF4758 5964..6171 CDD:292572 39/279 (14%)
DUF4758 6181..6360 CDD:292572 37/180 (21%)
DUF4696 6339..6999 CDD:292395 140/900 (16%)
DUF4758 6662..6839 CDD:292572 40/224 (18%)
DUF4758 6764..6941 CDD:292572 33/283 (12%)
DUF4758 6866..7045 CDD:292572 30/303 (10%)
DUF4758 6968..7179 CDD:292572 42/250 (17%)
DUF4696 7024..7569 CDD:292395 124/638 (19%)
DUF4758 7172..7383 CDD:292572 42/261 (16%)
DUF4696 7330..7964 CDD:292395 58/277 (21%)
DUF4758 7400..7587 CDD:292572 51/207 (25%)
DUF4758 7538..7707 CDD:292572 10/35 (29%)
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
crebbpaXP_005161826.1 zf-TAZ 325..392 CDD:280324 9/66 (14%)
KIX 548..628 CDD:280354 12/79 (15%)
PHA03193 <751..919 CDD:177555 48/232 (21%)
Bromo_cbp_like 980..1087 CDD:99927 12/106 (11%)
RING_CBP-p300 1099..1171 CDD:276805 16/77 (21%)
PHD_CBP 1172..1206 CDD:277117 6/48 (13%)
HAT_KAT11 1235..1542 CDD:285432 53/340 (16%)
ZZ_CBP 1598..1638 CDD:239077 1/39 (3%)
ZnF_TAZ 1659..1737 CDD:214717 12/94 (13%)
Med15 1902..>2333 CDD:255446 93/467 (20%)
Creb_binding 1957..2043 CDD:286163 12/85 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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