DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and zgc:165539

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001104646.1	Gene:	zgc:165539 / 564373	ZFINID:	ZDB-GENE-030131-5478	Length:	529	Species:	Danio rerio

Alignment Length:	555	Identity:	144/555 - (25%)
Similarity:	216/555 - (38%)	Gaps:	167/555 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  6902 TNVPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRTSP-SESPETPTTLP----SDFIT 6961
            |.|...||..|.:...:||.|: .||.|:   ...::.|.:::| |.||.|..:||    |.|||
Zfish    36 TGVSGQSTNDQSSPSLSSSVSQ-GTTYGV---ITQAQGTSQSAPGSSSPYTTISLPKYVASQFIT 96

  Fly  6962 RPHSDQTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEV 7026
            ||.|.|.|.         .:.....|||      |....|:||      .|||:..|..:|
Zfish    97 RPSSKQFTS---------VYGTQAGSSA------PFTLQESTT------YGGQIQTQDATS---- 136

  Fly  7027 RTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTT-------------------- 7071
            |..:            ..:||..|..:|..:.|..|..|.|.|.|
Zfish   137 RLVL------------GSSTPYISVSSPQVVTSPLTPGPGSKQVTSVYGTQTGSSALFTLQKLLQ 189

  Fly  7072 -ESSR----DVPTTQPFEASTPRPVTLQTAVLPVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTT 7131
             :.|:    .||:|.....|.|:.||.|:.::| .||..|:|....||       :|:|..::..
Zfish   190 GKGSKSQVVSVPSTPYVAVSLPQGVTSQSTLVP-NSEQLTSVYTTQTG-------SSAPFTLQEL 246

  Fly  7132 IRVEESTLPSRST-DRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPRPVTL 7195
            ::.::||  |:.. ..:||..|...|.::.|..|..|.|.|.|    .:.||   |:.:..|.||
Zfish   247 LQGQDST--SQGVYGSSTPYVSVSLPQSVTSQSTAVPSSKQIT----SIYTT---ETGSSAPFTL 302

  Fly  7196 ETAVPPVTSETTTNVPIGSTGGQ--------VTEQTTPSPSEVRTTIRIEESTFPSRSTDRTTP- 7251
            :..:.  ..::|:.|..||:...        ||.|.||.||..:.|     |.:.:: |..:.|
Zfish   303 QELLQ--GQDSTSQVVYGSSTPYVSVSLPQVVTSQLTPVPSSKQVT-----SVYGTQ-TGSSAPF 359

  Fly  7252 ----------SES-----PETP---TTLPSDFTTR----PHSDQ-----TTESTRDVPTT----- 7284
                      |:|     |.||   .:||...|::    |:|||     ||::...||.|
Zfish   360 TLQKLLQGKGSKSQVVSVPSTPYVAVSLPQGVTSQSTLVPNSDQLTSVYTTQTGSSVPFTLQELL 424

  Fly  7285 --------------RPFES-STPRPVTLEIAVPPVT-------SETTTNVAI---GSTGGQVTEQ 7324
                          .|:.| |.|..||.:.|||.:.       |:|.::..:   ||.||.:..|
Zfish   425 QGRDSSSQVVYGLSNPYVSVSMPPVVTSQSAVPSLKKITAVYGSQTGSSAPLTLQGSYGGLIQPQ 489

  Fly  7325 TTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPET 7359
            .....|...::    .|.|.:.:.|.:.||.|..|
Zfish   490 NAKDASSTGSS----SSVLQTSTGDFSNPSSSFST 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	32/101 (32%)
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572	11/38 (29%)
		DUF4758	6866..7045	CDD:292572	41/147 (28%)
		DUF4758	6968..7179	CDD:292572	55/236 (23%)
		DUF4696	7024..7569	CDD:292395	104/428 (24%)
		DUF4758	7172..7383	CDD:292572	63/254 (25%)
		DUF4696	7330..7964	CDD:292395	8/30 (27%)
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
zgc:165539	NP_001104646.1	Atrophin-1	97..>460	CDD:281189	106/424 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910