DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and col6a4a

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_017207020.1	Gene:	col6a4a / 564005	ZFINID:	ZDB-GENE-041111-303	Length:	2568	Species:	Danio rerio

Alignment Length:	584	Identity:	125/584 - (21%)
Similarity:	167/584 - (28%)	Gaps:	261/584 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly  8575 DPCATNAVCINSNHAADCSCADGFQG-NGFVGCQ--PARSHVCQYNEDCPPTKLCDRLNRRCINP 8636
            |..|:...|   |.|..||..:|.:| .|..|.:  |.|.....|                   |
Zfish  1562 DNIASRECC---NVACKCSGHEGSRGFQGLPGSKGLPGRRGNSGY-------------------P 1604

  Fly  8637 CQEDSCGENAECIPVNHGTECRCLPGFLGNAYVQCLP-------SQGCRSDSECDSSQACINGKC 8694
            .:|...||             |.|||..|....|..|       .:|.|.:          ||
Zfish  1605 GEEGGHGE-------------RGLPGLNGTRGNQGCPGRRGLKGGRGYRGE----------NG-- 1644

  Fly  8695 SSPCQCGAYALCDVVNHRGVCKCP--PGYNGNPKVGCSPPQDPCDPNPCGLNALCELDNGNPICY 8757
                :.|...|..|...:|....|  ||..|          ||.:|.|.|::.    .:|:|
Zfish  1645 ----EEGDNGLDGVDGEQGKTGAPGSPGERG----------DPGNPGPTGISG----SSGSP--- 1688

  Fly  8758 CPKGLTGNPFKNCIP------EGD------ECTPNPCG-----------PNSGCRRVGGNPVCFC 8799
            ..:||.|:|..:.:.      :||      :..|.|.|           ..||.|...|
Zfish  1689 GQRGLRGDPGNSGLDNNARGRKGDAGSAGMQGDPGPDGLAGQSGENGRPGQSGRRGTAG------ 1747

  Fly  8800 LPEYEGQPPSIP--CELP--SNPCDP-SPCGPNTQCSVLSNGFSKCTCLPNYVESPNTIRGCVEP 8859
            ||...| ||..|  ..||  |.|..| .|.||     |...||   ..||....||.:
Zfish  1748 LPGPRG-PPGDPGLQGLPGGSGPQGPFGPPGP-----VGQRGF---VGLPGPQGSPGS------- 1796

  Fly  8860 INPCDPNPCGT-GAICDSSRHPVCYCPDNKIGNPFRLCDKPAVTIELCQPGPCGRNAECYVAGNR 8923
                 |...|| |::  .||.                        :..|||..|.......||:|
Zfish  1797 -----PGRPGTKGSL--GSRG------------------------QKGQPGDPGEKGSLGSAGSR 1830

  Fly  8924 EECYCRSGYVGDAYQGCREPSRTVCDPNPCGPNANCVVAGDGQTACVCPDGLSGDPTSVIGCHGY 8988
             ....:.|..|..|.|.:                                |..||.    |..||
Zfish  1831 -GLPGKDGNDGYGYPGLK--------------------------------GQKGDS----GFPGY 1858

  Fly  8989 ECQVDADCPNSKACMGYRCYD----PCPGACGQGAHCQVEEHHPVCSCNSGLTGNPGIRCYALDH 9049
                    |..:..:|::..:    | .|:.|:|.             |:|.||.||       .
Zfish  1859 --------PGLQGELGFKGTNGGVGP-KGSRGRGG-------------NAGRTGPPG-------D 1894

  Fly  9050 P-------KKNPCVPSPCGRNSECKLLNN-RAVCSCIPGYLGDPQSGCQPECDINSDCGDTLSC 9105
            |       .:.|..|....:.|:|:|::. |..|.|                     |.|.:.|
Zfish  1895 PGSGGMTGHRGPKGPRGARQMSDCQLISYVRDNCMC---------------------CKDNIKC 1937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
col6a4a	XP_017207020.1	vWA_collagen	35..198	CDD:238749
		VWA	230..>362	CDD:278519
		VWA	416..588	CDD:278519
		VWA	622..784	CDD:278519
		VWA	807..975	CDD:278519
		VWA	995..1164	CDD:278519
		vWA_collagen	1184..1351	CDD:238749
		VWA	<1451..1548	CDD:214621
		Collagen	1584..1676	CDD:189968	31/149 (21%)
		Collagen	1659..1739	CDD:189968	21/96 (22%)
		Collagen	1786..1840	CDD:189968	18/92 (20%)
		Collagen	1842..1912	CDD:189968	23/134 (17%)
		VWA	1943..2107	CDD:278519
		VWA	2153..2325	CDD:278519
		Kunitz_BPTI	2438..2490	CDD:278443
		Kunitz_BPTI	2510..2561	CDD:278443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910