DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and cuzd1.2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_021323075.1 Gene:cuzd1.2 / 555768 ZFINID:ZDB-GENE-131119-30 Length:718 Species:Danio rerio


Alignment Length:754 Identity:158/754 - (20%)
Similarity:224/754 - (29%) Gaps:293/754 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly 22210 RQGFEGNPEFECSKIECSINSDCPGTHVCRNQLCIPACQGEQCGSNAQCLAIEHRAVCECIPGHG 22274
            |:||..|..|..|      ||       |||          .||.:.        ..|.|     
Zfish   118 RRGFHANWVFLDS------NS-------CRN----------YCGFSF--------GTCSC----- 146

  Fly 22275 GNARIACTPLGCRSDDECPTDKACVNGKCNDPCTTTALCAQDELCKVYHHRPQCACPPGTVPGKN 22339
                          ||.|..::.|    |.|   ..:.|.|..........|.|....|..||..
Zfish   147 --------------DDSCQDNRNC----CFD---YNSYCFQTTTWPTTTDIPSCMYNCGYNPGSC 190

  Fly 22340 GCESERHIPICISDADCPSQKACLRGECVNPCNATQPCGVNAFCSVRDTL----PVRTMICECLE 22400
            .|..     .|..|.:|          |.:         ..|:||...|.    |..|.|..|:.
Zfish   191 SCTD-----FCQRDGNC----------CPD---------YEAYCSETTTTTAFEPDTTEILSCMY 231

  Fly 22401 --GYT-GNPAVQCDKRSLCVIEKGFVRDVDGQCVCPPGTALDIYEYCTPCREEQGFRIDESGHCV 22462
              ||. |.    |.....|   :.:     |.| ||     |...||:...... |..|.:.|. 
Zfish   232 NCGYNLGG----CSCTEFC---RSY-----GNC-CP-----DYEAYCSETTTTT-FEPDTTAHS- 276

  Fly 22463 CALERGMVIDERGRCTCPIDLGYRLTPRGECQPEEPPEC----------------TSNDQCA--- 22508
            |....|.   :.|.|:|..|..|    ...|.|:....|                .|:.:|.   
Zfish   277 CMYNCGY---DLGSCSCARDCHY----YDICCPDYDSHCPSYTTLRDSTTELHYTESHPKCGGHL 334

  Fly 22509 ----------------DNRFC--NLDTK-------TCEDPCLTKVCGVNAFCNAVNHRAQCQCIT 22548
                            ||.:|  .|..:       |..|..|.:.|             .|..||
Zfish   335 YGAGLFSTPNYPSYYHDNAYCVWYLSAQQGQRIFLTFADVQLERCC-------------DCDYIT 386

  Fly 22549 ----GYTGNPDLH--C-NHTN--------------FRTDF---------------PRPDMVVSCL 22577
                ..||.|.|.  | |.|.              ||:||               ......|.|.
Zfish   387 IHDGSSTGYPQLGNVCFNDTTHQAFHSTSRYLTVVFRSDFSGVSHGFKAHFTSSLTADQGRVDCS 451

  Fly 22578 ADGVQVEI---HITEPGFNG-VLYVKGHSKDEECRRVVNLAGETVPRTE-IFRVHFGSCGMQAVK 22637
            :|.:.:.:   ::...||:| .|||    .|..||       ..:..|| :||....:|| .|.|
Zfish   452 SDNMVIVLRRSYLNSLGFSGNDLYV----DDRLCR-------PNISSTEVVFRFPLNTCG-TAKK 504

  Fly 22638 DVASFVL-------------VIQKHPKL---------------VTYKAQAYNIKCVYQTGEKNVT 22674
            .:.|||.             ||.:..:.               :.|||:......:..||..|.:
Zfish   505 MMNSFVSYTNNVRASPSQSGVITRQSEFLLSVGCRMEPDTIVQIFYKAEEIPNGNITGTGRFNAS 569

  Fly 22675 LGFNVSMLTTAGTIANTGPPPICQMRIITNEGEEINSAEIGDNLKLQVDVEPATIYGG----FAR 22735
            :.|..|..              ...:|..:..|    ..:.|:|.:||.:   |.:..    |..
Zfish   570 IAFYTSRK--------------FNQQIYDSPYE----VYLNDDLFVQVKL---TRFDASLDLFLE 613

  Fly 22736 SCIAKTMEDNVQNEYLVTDENGCATDTSIFGNWEYNPDTNSLLASFNAFKF-PSSDNIRFQCNIR 22799
            :|:|....::.::.......|||..| |.|.::....|..:.. ||.|||| .:...:..||.:.
Zfish   614 TCVASPNPNDFKDYSYDLLRNGCPRD-STFQSYINGVDQYAQF-SFRAFKFLQTHAYVHLQCQVI 676

  Fly 22800 VCFGRCQPVNCGGYNAFGR-----RRRSIADNSTDATAI 22833
            :|     |.|  .||:..|     ||:...|:|.:.:.:
Zfish   677 IC-----PDN--DYNSRCRKGCQYRRKRSLDSSYNTSTV 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579 60/272 (22%)
Zona_pellucida <22714..22810 CDD:278526 25/100 (25%)
cuzd1.2XP_021323075.1 CUB 21..127 CDD:238001 4/8 (50%)
Somatomedin_B 131..164 CDD:307259 15/83 (18%)
Somatomedin_B 175..214 CDD:321959 13/62 (21%)
Somatomedin_B <239..260 CDD:307259 7/38 (18%)
CUB 330..439 CDD:238001 23/121 (19%)
ZP 450..694 CDD:214579 63/285 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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