DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Nell2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001276582.1	Gene:	Nell2 / 54003	MGIID:	1858510	Length:	819	Species:	Mus musculus

Alignment Length:	869	Identity:	201/869 - (23%)
Similarity:	275/869 - (31%)	Gaps:	348/869 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GEVFYLNLEN---GYFGCQVNESTEYL--------QLFNLSKLCDGTQDCFLG--------ADEL 87
            |..|:|...|   |||. .:.:....|        |..:|::.|....| |.|        .|.|
Mouse   189 GTTFWLGQRNNAHGYFK-GIMQDVHVLVMPQGFIAQCPDLNRTCPTCND-FHGLVQKIMELQDIL 251

  Fly    88 SK----------------ELKCTNDCDKDGTK----------CTHGACLNGVCHCN--------- 117
            ||                :..|...|...||.          |.:..||||...|.
Mouse   252 SKTSAKLSRAEQRMNRLDQCYCERTCTVKGTTYRESESWTDGCKNCTCLNGTIQCETLVCPAPDC 316

  Fly   118 -----DGYGGCNCVDKDENECKQRPCDVFAHCTNTLGSFTCTCFPGYRGNGFHCEDIDECQDPAI 177
                 ..|....|..:.::.|:.:....|....||:.|.:..|.            :.||:|..:
Mouse   317 PPKSAPAYVDGKCCKECKSTCQFQGRSYFEGERNTVYSSSGMCV------------LYECKDQTM 369

  Fly   178 AARCVENAECCNLP---------AHFLCKCKDGYEGDGEVLCTDVDECRNPENCGPNALCTNTPG 233
              :.|||..|..|.         :|..||...||           |.|.....|..|::|.|...
Mouse   370 --KLVENIGCPPLDCPESHQIALSHSCCKVCKGY-----------DFCSEKHTCMENSVCRNLND 421

  Fly   234 NYTCSCPDGYVG---NNPYREGCQDVDECSY-PNVCGPGAICTNLEGSYRCDCPPGY---DGDGR 291
            ...|||.||:..   :|.|   |:|:|||:. .:.|....:|.|..||:.|.|..||   |
Mouse   422 RAVCSCRDGFRALREDNAY---CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID---- 479

  Fly   292 SESGCVDQDECARTP--CGRNADCLNTDGSFRCLCPDGYSGDPMNG------CEDVDECATNNPC 348
             :..|.:.|||....  |..||.|.||.|...|:|..||:|   ||      |:|        .|
Mouse   480 -DYSCTEHDECLTNQHNCDENALCFNTVGGHNCVCKPGYTG---NGTTCKAFCKD--------GC 532

  Fly   349 GLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLAC-L 412
            ..|..|:   .:..|.||.||.                     ||                :| .
Mouse   533 RNGGACI---AANVCACPQGFT---------------------GP----------------SCET 557

  Fly   413 DIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHCENINECQDNPCGENAICTDTVG 477
            |||||:  :|..:|.:.|.|||.||.|.|.|..|:...|..          .|.||:
Mouse   558 DIDECS--EGFVQCDSRANCINLPGWYHCECRDGYHDNGMF----------APGGES-------- 602

  Fly   478 SFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQV 542
                             |.|||||......|....:|.|...||:|:||.|.:
Mouse   603 -----------------CEDIDECGTGRHSCTNDTICFNLDGGYDCRCPHGKN------------ 638

  Fly   543 DVNILCSSNFDCTNNAECIE-NQCFCLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPGSYGC 606
                 |:.  ||.:..:... .|.:.|:.           |.|..                   |
Mouse   639 -----CTG--DCVHEGKVKHTGQIWVLEN-----------DRCSV-------------------C 666

  Fly   607 ECEAGYVGSPPRMA--CKQPCEDVRCGAHAYCKPDQNEAYCVCEDGWT-YNPSDVAAGCVDIDEC 668
            .|:.|:| ...||.  |:.|..|:.|...  |.| :..:.|:.::|.| ||..|  ....|..:|
Mouse   667 SCQTGFV-MCRRMVCDCENPTVDLSCCPE--CDP-RLSSQCLHQNGETVYNSGD--TWVQDCRQC 725

  Fly   669 DVMHGPFGSCGQNATCTNSAGGFTCACPP---GFSGDPHSKCVDVDECRTGASKCGAGAECVNVP 730
            ..:.|       ...|      :..|||.   .||..|.::|
Mouse   726 RCLQG-------EVDC------WPLACPEVECEFSVLPENEC----------------------- 754

  Fly   731 GGGYTCRCPGNTIADPDPSVRCVPIVSCSANEDCPGNSI-CDATKRCLCPEPNI----------- 783
                   ||           |||       .:.|..::| .|.||.|| .|.|:
Mouse   755 -------CP-----------RCV-------TDPCQADTIRNDITKTCL-DEMNVVRFTGSSWIKH 793

  Fly   784 GNDCRHPCEALN----CGAHAQCM 803
            |.:|. .|:..|    |....||:
Mouse   794 GTECT-LCQCKNGHLCCSVDPQCL 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	5/28 (18%)
		EGF_CA	212..247	CDD:238011	11/37 (30%)
		EGF_CA	255..>286	CDD:214542	11/31 (35%)
		EGF_CA	298..331	CDD:238011	14/34 (41%)
		EGF_CA	338..373	CDD:238011	9/34 (26%)
		EGF_CA	413..456	CDD:238011	18/42 (43%)
		EGF_CA	457..490	CDD:238011	3/32 (9%)
		EGF_CA	497..>529	CDD:214542	13/31 (42%)
		EGF_CA	580..>612	CDD:214542	4/31 (13%)
		EGF_3	676..702	CDD:289699	6/28 (21%)
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Nell2	NP_001276582.1	TSPN	32..217	CDD:214560	8/28 (29%)
		VWC	277..333	CDD:327433	11/55 (20%)
		EGF_CA	443..>475	CDD:311536	11/31 (35%)
		EGF_3	489..524	CDD:372403	15/37 (41%)
		EGF_CA	558..592	CDD:214542	17/35 (49%)
		EGF_CA	605..>636	CDD:311536	13/30 (43%)
		VWC	708..758	CDD:327433	18/105 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910