DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and CFP

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001138724.1	Gene:	CFP / 5199	HGNCID:	8864	Length:	469	Species:	Homo sapiens

Alignment Length:	565	Identity:	124/565 - (21%)
Similarity:	168/565 - (29%)	Gaps:	212/565 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly 14623 CLPEYIGAPPNCRPEC---VTSSECPTNQACIQQK--------CRDPCPGLCGQSAECRVLSHTP 14676
            |..:|..:...|:...   |:..:|..|.|...||        ||.|...|....|.|
Human    32 CFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPC------- 89

  Fly 14677 SCVCPEGMEGDPFTLCKEKRIQELDQLDPCSPSPCGINARCTSRQDAG-------SC---QCLPD 14731
            |..|.||.:      .:.:|         |    .|.|.:|:.:...|       :|   ||.|:
Human    90 SVTCSEGSQ------LRYRR---------C----VGWNGQCSGKVAPGTLEWQLQACEDQQCCPE 135

  Fly 14732 YFG----NPYEGCRPECVLNSDCPSNKACQQ--QKCQDPCPGTCGQNALCNVLNHIPS------- 14783
            ..|    .|:|.|...|...:. ...:||..  .||...|||...::..|:.....|:
Human   136 MGGWSGWGPWEPCSVTCSKGTR-TRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW 199

  Fly 14784 ---CSCISGYSGDPYRSCVPEPVKEYVNPC---QPSPCGPNSQCREV-NEQAICSCLPEYVGAPP 14841
               ..|.:...|.|:     ||.:.....|   :||...|...|..: .||..|:      |.||
Human   200 GPWTPCSASCHGGPH-----EPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT------GLPP 253

  Fly 14842 VCRPECTISSECPADKACVNQKCVDPCPNTCG-----DQAICRVVNH------SPICSCRAGYTG 14895
                       ||..........|.|||.|||     :|..|   ||      .|.|:      |
Human   254 -----------CPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC---NHPVPQHGGPFCA------G 298

  Fly 14896 DAFFRCFPKPPVPPTPVQKTPV-DPCVPTPC-------GPYSQC-RSQGDAPACSCLVGYIGAPP 14951
            ||               .:|.: :..||.|.       |.:|.| |....:.:|..:.|......
Human   299 DA---------------TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR 348

  Fly 14952 NCRPECRINAECPSSQACINEKCRDPCPGSCGYGAICNVINHTPSCTCPPGYSGDPFSQ---CQP 15013
            .||........|...|..|..               |..|.|     ||...|...:|.   |.|
Human   349 TCRGRKFDGHRCAGQQQDIRH---------------CYSIQH-----CPLKGSWSEWSTWGLCMP 393

  Fly 15014 VPPPPPTPVKLDDPCNPSPCGPN-AQCNNGVCT-CIPEYHGDPYSGCRPECITSADCSRELACSR 15076
                              ||||| .:....:|| .:|:|         |..::..:...|    :
Human   394 ------------------PCGPNPTRARQRLCTPLLPKY---------PPTVSMVEGQGE----K 427

  Fly 15077 NKCF--DPCPGTCAPNAICTVLN-------------HVPMCTCPE 15106
            |..|  .|.|.       |..|.             |||.|..||
Human   428 NVTFWGRPLPR-------CEELQGQKLVVEEKRPCLHVPACKDPE 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CFP	NP_001138724.1	TSP_1	81..132	CDD:306574	14/76 (18%)
		TSP_1	140..184	CDD:306574	11/44 (25%)
		TSP1	196..255	CDD:214559	16/80 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..238		4/18 (22%)
		TSP_1	261..312	CDD:306574	18/74 (24%)
		Interaction with Compliment C3 beta chain. /evidence=ECO:0000269\|PubMed:28264884, ECO:0000269\|PubMed:31507604	351..359		1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900