DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and NOTCH3

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens


Alignment Length:1859 Identity:495/1859 - (26%)
Similarity:689/1859 - (37%) Gaps:568/1859 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 CTNDCDKDGTKCTHGACLNGVCHCNDGYGGCNCVDKDENECKQRPCDVFAHCTNTL----GSFTC 153
            |.|     |.:||........|.|..|:.|..|  :.|:.|...||.....|.:::    ..|:|
Human    49 CAN-----GGRCTQLPSREAACLCPPGWVGERC--QLEDPCHSGPCAGRGVCQSSVVAGTARFSC 106

  Fly   154 TCFPGYRGNGFHCEDIDECQ--DPAIAARCVENAECCNLP-AHFLCKCKDGYEGDGEVLC-TDVD 214
            .|..|:||        .:|.  ||.:::.|...|.|...| ..|||.|..||:|..   | :|||
Human   107 RCPRGFRG--------PDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRS---CRSDVD 160

  Fly   215 ECRNPENCGPNALCTNTPGNYTCSCPDGYVG-----------NNPYREG--CQDVDECSYPNVCG 266
            |||..|.|.....|.||||::.|.||.||.|           .:|.|.|  |:...:.:|...|.
Human   161 ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACL 225

  Fly   267 P---------------------GAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECARTP--CG 308
            |                     |..|.:...:|.|.|||.:.|...:|    |.|||...|  |.
Human   226 PGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTE----DVDECQLQPNACH 286

  Fly   309 RNADCLNTDGSFRCLCPDGYSGDPMNGCEDVDECATNNPCGLGAECVNLGGSFQCRCPSG----- 368
            ....|.||.|...|:|.:|::|:..:  :::|:||| ..|..||.|.:...||.|.||.|     
Human   287 NGGTCFNTLGGHSCVCVNGWTGESCS--QNIDDCAT-AVCFHGATCHDRVASFYCACPMGKTGLL 348

  Fly   369 -----FVLEHDPHADQL--PQPLNTQQL-----GYGPGATDIAPYQRTSGAGLACLDIDECNQPD 421
                 ..:.:..|.|.:  ..|:|.:.:     |:..||.|              .|:|||:  .
Human   349 CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACD--------------QDVDECS--I 397

  Fly   422 GVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHCE-NINECQDNPCGENAICTDTVGSFVCTCKP 485
            |...|....:|:|..||:.|.|..|:.|.   .|| ::|||...||...|.|.|.:|.|.|.|..
Human   398 GANPCEHLGRCVNTQGSFLCQCGRGYTGP---RCETDVNECLSGPCRNQATCLDRIGQFTCICMA 459

  Fly   486 DYTGDPFRGC-VDIDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCS 549
            .:||   ..| ||||||.:  .||....||::.|.|::|.||.|:.|.     .| |:||: .|:
Human   460 GFTG---TYCEVDIDECQS--SPCVNGGVCKDRVNGFSCTCPSGFSGS-----TC-QLDVD-ECA 512

  Fly   550 SNFDCTNNAECIEN----QCFCLDGFEPIGSSC-VDIDECRTHAEVCGPHAQCLNTPGSYGCECE 609
            |. .|.|.|:|::.    :|.|.:|||  |:.| .::|:|  ..:.| .|.:|::...|:.|.|.
Human   513 ST-PCRNGAKCVDQPDGYECRCAEGFE--GTLCDRNVDDC--SPDPC-HHGRCVDGIASFSCACA 571

  Fly   610 AGYVGSPPRMACKQPCEDVR---CGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGC-VDIDECDV 670
            .||.|:    .|:...::.|   |.....|....::..|.|..|.|      ...| |:||:|..
Human   572 PGYTGT----RCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTT------GVNCEVNIDDCAS 626

  Fly   671 MHGPFGSCGQNATCTNSAGGFTCACPPGFSGDPHSKC-VDVDECRTGASKCGAGAECVNVPGGGY 734
            ....||      .|.:....:.|.|.|||:|   ..| |:::||  .:|.||.|..||: ...|:
Human   627 NPCTFG------VCRDGINRYDCVCQPGFTG---PLCNVEINEC--ASSPCGEGGSCVD-GENGF 679

  Fly   735 TCRCPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAH 799
            .|.||                         ||:    ....||.|.        |||....| :|
Human   680 RCLCP-------------------------PGS----LPPLCLPPS--------HPCAHEPC-SH 706

  Fly   800 AQCMLANGQAQCLCAPGYTG---NSALAGGCNDIDECRANPCAEKAICSNTAGGYLCQCPGGSSG 861
            ..|..|.|..:|:|.||::|   :.:||.     |.|.:.||.....||:...|:.|.||.|..|
Human   707 GICYDAPGGFRCVCEPGWSGPRCSQSLAR-----DACESQPCRAGGTCSSDGMGFHCTCPPGVQG 766

  Fly   862 DPYREGCITSKTVGCSDANPCATGETCVQDSYTGN-SVCICRQGYERNSENGQC-QDVDECSVQR 924
               |:..:.|.   |: .|||..|..|  :|..|. .||.|.||:    :..:| ||||||:   
Human   767 ---RQCELLSP---CT-PNPCEHGGRC--ESAPGQLPVCSCPQGW----QGPRCQQDVDECA--- 815

  Fly   925 GKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQA 989
            |...||.:.:|.||.||:.|.|..|:.|           |.|....      |.|..:.|.:|.:
Human   816 GPAPCGPHGICTNLAGSFSCTCHGGYTG-----------PSCDQDI------NDCDPNPCLNGGS 863

  Fly   990 CPSGAECISIAGGVSYCACPKGYQTQPDGSCV-DVDECEERGAQLCAFGAQCVNKPGSYSCHCPE 1053
            |..|....|       |:|..|:   ....|. |||||.   :..|..|. |.:...|::|.||.
Human   864 CQDGVGSFS-------CSCLPGF---AGPRCARDVDECL---SNPCGPGT-CTDHVASFTCTCPP 914

  Fly  1054 GYQGDAYNGLCALAQRKCAADRECAANEKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINA 1118
            ||.|           ..|..|....:...|...|.||                       .|:|:
Human   915 GYGG-----------FHCEQDLPDCSPSSCFNGGTCV-----------------------DGVNS 945

  Fly  1119 KCTPSDPPQCMCEAGFKGDPLLGCTDE-DECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSG 1182
            .       .|:|..|:.|   ..|..| |.|...||.:|..|.....|::|.|.:.:||      
Human   946 F-------SCLCRPGYTG---AHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTG------ 994

  Fly  1183 CIFESGTPKSKCLSNDDCASNLACLEGS-CVSPCSSLLCGSNAYCETEQHAGW-----------C 1235
                     .:|.:..|..|...|..|. ||.        :.|||...  .||           |
Human   995 ---------PQCQTLVDWCSRQPCQNGGRCVQ--------TGAYCLCP--PGWSGRLCDIRSLPC 1040

  Fly  1236 RCRVGYVKNGDGDCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSC--STDQCSAAR 1298
            |.....:    |..:.|    :|..|..|:.......|.||:|:.|:     .|  ..|.| .|:
Human  1041 REAAAQI----GVRLEQ----LCQAGGQCVDEDSSHYCVCPEGRTGS-----HCEQEVDPC-LAQ 1091

  Fly  1299 PCGERQICINGRCKERCEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGEN 1363
            ||..     .|.|:....|.:|.             |.|.:.|:.   |...:::....| |...
Human  1092 PCQH-----GGTCRGYMGGYMCE-------------CLPGYNGDN---CEDDVDECASQP-CQHG 1134

  Fly  1364 AHCEYGLGQSRCACNPGTFGNPYEGCGAQSKNVCQPN--SCGP------------NAECRAVGNH 1414
            ..|...:.:..|:|.|||.|           .:|:.|  .|||            |..|..:...
Human  1135 GSCIDLVARYLCSCPPGTLG-----------VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGG 1188

  Fly  1415 ISCLCPQGFSGNPYIGCQ-DVDECANKPCGLNAA----CL-NRAGGFECLCLSGHAGNPYSSCQ- 1472
            ..|.||.|::|   :.|: |::||.:..|  :||    || :..|||.|||   |||.....|| 
Human  1189 FRCTCPPGYTG---LRCEADINECRSGAC--HAAHTRDCLQDPGGGFRCLC---HAGFSGPRCQT 1245

  Fly  1473 ---PIESKFCQDANKCQ------------CN----------ERV-------ECPEGYSCQKGQCK 1505
               |.||:.||...:|:            |:          |||       :||.|..||     
Human  1246 VLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQ----- 1305

  Fly  1506 NLCSQASCGPRAICDAGNCICPMGYIGDPHDQVHGC---SIRGQCGNDADCLHSEICFQLGKGLR 1567
                |...|||       |.||.|..|.......|.   :....|. .|.|||..          
Human  1306 ----QTPRGPR-------CACPPGLSGPSCRSFPGSPPGASNASCA-AAPCLHGG---------- 1348

  Fly  1568 KCVDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPE--EEDKCKSDQDCS 1630
                     .|.|..|...    ..|.|:.|:.| |.     |:.....||  ||.:|..     
Human  1349 ---------SCRPAPLAPF----FRCACAQGWTG-PR-----CEAPAAAPEVSEEPRCPR----- 1389

  Fly  1631 RGYGCQASVNGIKECINLCSNVVCG-PNELCKINPAGHAICNCAESYVWNPVVSS-CEKPSLPDC 1693
              ..|||. .|.:.|...|::..|| ....|.:: .|.....|.....|....:| |:    |.|
Human  1390 --AACQAK-RGDQRCDRECNSPGCGWDGGDCSLS-VGDPWRQCEALQCWRLFNNSRCD----PAC 1446

  Fly  1694 TSDANCPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRCDCLNGFVGNPNDRNGCQPA 1758
            :|.|                   .:.|.|.|.|.         ||             ...|.|.
Human  1447 SSPA-------------------CLYDNFDCHAG---------GR-------------ERTCNPV 1470

  Fly  1759 QKHHCRNH-AECQESEACIKDESTQTLGCRPACDTVKCG 1796
            .:.:|.:| |:.:               |...|:|.:||
Human  1471 YEKYCADHFADGR---------------CDQGCNTEECG 1494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 9/32 (28%)
EGF_CA 212..247 CDD:238011 19/45 (42%)
EGF_CA 255..>286 CDD:214542 10/51 (20%)
EGF_CA 298..331 CDD:238011 13/34 (38%)
EGF_CA 338..373 CDD:238011 14/44 (32%)
EGF_CA 413..456 CDD:238011 14/42 (33%)
EGF_CA 457..490 CDD:238011 13/32 (41%)
EGF_CA 497..>529 CDD:214542 14/31 (45%)
EGF_CA 580..>612 CDD:214542 8/31 (26%)
EGF_3 676..702 CDD:289699 7/25 (28%)
EGF_CA 1022..1056 CDD:214542 13/33 (39%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
EGF_CA 158..195 CDD:238011 19/36 (53%)
EGF_CA 236..272 CDD:238011 8/35 (23%)
EGF_CA 274..311 CDD:238011 14/36 (39%)
EGF_CA 314..349 CDD:238011 14/35 (40%)
EGF_CA 391..429 CDD:238011 14/42 (33%)
EGF_CA 431..467 CDD:238011 14/38 (37%)
EGF_CA 469..505 CDD:238011 17/43 (40%)
EGF_CA 507..542 CDD:238011 14/38 (37%)
EGF_CA 545..580 CDD:238011 11/41 (27%)
EGF_CA 583..618 CDD:238011 7/40 (18%)
EGF_CA 620..654 CDD:238011 12/42 (29%)
EGF_CA 657..>686 CDD:214542 12/56 (21%)
EGF_CA 810..846 CDD:238011 18/49 (37%)
EGF_CA 849..884 CDD:238011 10/50 (20%)
EGF_CA 887..922 CDD:238011 15/49 (31%)
EGF_CA 929..960 CDD:238011 10/63 (16%)
EGF_CA 1085..1120 CDD:238011 12/56 (21%)
EGF_CA 1122..1158 CDD:238011 9/47 (19%)
EGF_CA 1171..1203 CDD:238011 7/34 (21%)
Notch 1384..1418 CDD:278494 10/41 (24%)
LNR 1 1387..1427 11/48 (23%)
Notch 1425..1459 CDD:278494 10/56 (18%)
LNR 2 1428..1458 10/52 (19%)
Notch 1464..1500 CDD:278494 10/46 (22%)
LNR 3 1467..1505 10/43 (23%)
NOD 1508..1557 CDD:284282
NODP 1578..1637 CDD:284987
ANKYR <1777..1893 CDD:223738
ANK <1779..1892 CDD:238125
ANK repeat 1788..1836 CDD:293786
ANK repeat 1838..1869 CDD:293786
ANK 1 1838..1867
Ank_5 1858..1913 CDD:290568
ANK 1866..1992 CDD:238125
ANK repeat 1871..1903 CDD:293786
ANK 2 1871..1901
ANK repeat 1905..1936 CDD:293786
ANK 3 1905..1934
Ank_2 1910..2002 CDD:289560
ANK repeat 1938..1969 CDD:293786
ANK 4 1938..1967
ANK repeat 1971..2002 CDD:293786
ANK 5 1971..2000
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321
DUF3454 2212..2273 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11819
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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