DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and PPP1R12A

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001137357.1	Gene:	PPP1R12A / 4659	HGNCID:	7618	Length:	1030	Species:	Homo sapiens

Alignment Length:	775	Identity:	168/775 - (21%)
Similarity:	266/775 - (34%)	Gaps:	224/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4630 GQTTAPPSE-----FRTTIRVEESTLPSRSTDRTTP----------------SESPETPTILPSD 4673
            |||....::     :...::.:::.|.|...|:.:|                .::.||..|.|..
Human   265 GQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEK 329

  Fly  4674 STTRTYS------DQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVTE 4732
            :.:|..|      |:..|..:|       |:|..|....|....| ..||....|:.|.....|.
Human   330 NASRIESLEQEKVDEEEEGKKD-------ESSCSSEEDEEDDSES-EAETDKTKPLASVTNANTS 386

  Fly  4733 QTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRP 4797
            .|.::|..|         |.|:.|:.:.||               |.|..:..|.:|:..|....
Human   387 STQAAPVAV---------TTPTVSSGQATP---------------TSPIKKFPTTATKISPKEEE 427

  Fly  4798 FEASTPSSASLETTVPSVTLETTTNVPIGSTG--GQVTEQTTSSPSEVRTTIRVEESTLPSRSAD 4860
            .:..:|:               |..:.:..||  |.:.|.|.|           :|......:|.
Human   428 RKDESPA---------------TWRLGLRKTGSYGALAEITAS-----------KEGQKEKDTAG 466

  Fly  4861 RTTPSESPETPTTLPSDFITRPHSEKTTESTR---DVPTTRPFEASTP--------SSASLETTV 4914
            .|..:.||...::|.:     ...||.::.||   ..||.....|||.        .|:||.|:
Human   467 VTRSASSPRLSSSLDN-----KEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTS- 525

  Fly  4915 PSVT-------LETTTNVPIGST-------GGQVTE-------QTTSSPSEVRTTIRVEESTLPS 4958
            .|.|       |:..::|..|||       |.:..:       .|||:|: |.:...:::|.|.|
Human   526 SSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPT-VTSAAGLQKSLLSS 589

  Fly  4959 RSTDR--TTPSESPETPTTLPSDFTTRPHSEQTTESTRD-VPTTRPFEASTPSPASLETTVPSVT 5020
            .||..  ||.|.|..|    .|..:.|..:|.:||..:| |||.    .:.|...::.....|.|
Human   590 TSTTTKITTGSSSAGT----QSSTSNRLWAEDSTEKEKDSVPTA----VTIPVAPTVVNAAASTT 646

  Fly  5021 LETTTNVPIGSTGGQVTEQTTSSPSEVR-------TTIRVEESTLPSRSADRTTPSESPETPTTL 5078
            ..|||           |..|.||.:|||       |.:|.|||....::..|
Human   647 TLTTT-----------TAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR------------- 687

  Fly  5079 PSDFITRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTT 5143
                    .:.|:..||:.|..|...||        |.|:....|..|
Human   688 --------QARQSRRSTQGVTLTDLQEA--------EKTIGRSRSTRT----------------- 719

  Fly  5144 APPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFT---TRPHSDQTTESTRDVPTTRP 5205
                  |.....|:........|:....|..|:.|:...::.   :|.: |:|.:..|.|.|:
Human   720 ------REQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTY-DETYQRYRPVSTS-- 775

  Fly  5206 FEASTPSPASLETTVPSVTLETTTNVP---IGSTGGQ---VTEQTTSSPSEVRTTIRVEESTLPS 5264
             .::||| :||.|...|:...:..|.|   :|.|...   :|::......:.......|:.:.|.
Human   776 -SSTTPS-SSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPK 838

  Fly  5265 RSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDV-PATRPFEASTPSPASLETTVPS 5323
            ...:|..|.|...:..:  .|.|:...|...|...|. ..:...|..|.|.:..||:..|
Human   839 SIRERRRPREKRRSTGV--SFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTS 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	11/68 (16%)
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572	30/150 (20%)
		DUF4758	4683..4847	CDD:292572	33/165 (20%)
		DUF4758	4785..4964	CDD:292572	48/214 (22%)
		DUF4696	4841..5385	CDD:292395	121/535 (23%)
		DUF4758	4887..5098	CDD:292572	65/252 (26%)
		DUF4758	5193..5371	CDD:292572	32/138 (23%)
		DUF4758	5294..5487	CDD:292572	8/31 (26%)
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
PPP1R12A	NP_001137357.1	KVKF motif	35..38
		ANK 1	39..68
		Ank_2	47..136	CDD:289560
		ANK	67..252	CDD:238125
		ANK repeat	72..103	CDD:293786
		ANK 2	72..101
		ANK repeat	105..136	CDD:293786
		ANK 3	105..134
		ANK repeat	138..229	CDD:293786
		ANK 4	138..164
		ANK 5	198..227
		Ank_4	199..252	CDD:290365
		ANK	226..>301	CDD:238125	6/35 (17%)
		ANK repeat	231..262	CDD:293786
		ANK 6	231..260
		Ank_4	232..280	CDD:290365	3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..628		93/406 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..928		69/324 (21%)
		Interaction with ROCK2. /evidence=ECO:0000269\|PubMed:19131646	682..864		43/240 (18%)
		PRKG1_interact	931..1029	CDD:292521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910