DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and nompA

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_524831.2 Gene:nompA / 45587 FlyBaseID:FBgn0016047 Length:1557 Species:Drosophila melanogaster


Alignment Length:1758 Identity:341/1758 - (19%)
Similarity:534/1758 - (30%) Gaps:692/1758 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly 21482 QQTC------TVLDTLPKRAMACKCPGDTVTDISRNCVPITVP--KVISGCQHNSECANTEVCSN 21538
            |.||      .:.:.||.:.:. ....|.|.|        |.|  :|:..||             
  Fly    26 QTTCKNGLGRVLYERLPNQQLQ-GYDDDVVRD--------TAPPFRVLEKCQ------------- 68

  Fly 21539 GNCLDACRLERCGVN---AQCTARDHYAQCNCPKGFQGNPRIE---CY-TTEVDVPR-------I 21589
                |.|..:|.|.|   ..||:.| :...:....|.||...|   || |:|...|.       :
  Fly    69 ----DLCLRDRSGSNNLVRTCTSFD-FQPGSRITSFGGNSEYEESLCYLTSEQAGPEGIGSLMLV 128

  Fly 21590 PNPGCSRNDDCPRDQICRNEICISPCAAD-DCGIGAYCHVQQRKAICRCPPGYTGNPQERC-LPP 21652
            ||            .:..||||::....: :|....|.              :..:|:::. ||.
  Fly   129 PN------------SVHFNEICLTSSRPERECPSRRYV--------------FERHPRKKLKLPI 167

  Fly 21653 SDVILVGCKSSTDCPSNEACINTQCASPCNCGPNAECTVKNHHPICYCKPGFSGNAQFGCAPIGC 21717
            ||:..:...:.:||  .:.|:|.                            ||         ..|
  Fly   168 SDIKEITAANRSDC--EDKCLNE----------------------------FS---------FVC 193

  Fly 21718 RSDDECSGDKQCVNRECINPCLASDPCALNAECYGRNHRANCRCPVGLEGDPFVRCLRLECHSDY 21782
            ||.:..|..:.|.......                |.|      |..:|.||         :|||
  Fly   194 RSANFDSTMRSCTLSRFTR----------------RTH------PELMEDDP---------NSDY 227

  Fly 21783 DCASNLACVSNECVSPCGQRNPCAQNAICQALQHRAVCRCPDQLPLGNPYAYCEPRPVEPVCRDD 21847
                    :.|.|::  .:|.       |..|   ||....:...||.|:              :
  Fly   228 --------LENTCLN--AERR-------CDGL---AVFVKEENKRLGGPF--------------E 258

  Fly 21848 GDCPSKLACIDDKCQDPCSVLSPCHPTAQCSVLNSVPVRTMVCECAEYEVPDASGACRKMMPPRL 21912
            .|..:.:..  ::||..|                   :|.....|...|..|.|..|        
  Fly   259 VDIFNNMTL--EECQTMC-------------------LRAEKYFCRSVEFDDQSKQC-------- 294

  Fly 21913 PGCESDQDCPDQEACIHAQCRNPCNCGTNAVCQVTQHRAVCSCQDGFEGNPY------------- 21964
              ..|::|...|:..|... .:|           |.|.....|.|....|.|             
  Fly   295 --ILSEEDSISQKDDISIS-SSP-----------THHFYDLVCLDNQRANDYPDNSVTSHLFSSG 345

  Fly 21965 -----ASCRSIGCRVDGECDSGKACINGDCINPCLINDPC--GPNAEC--YVQSNRAQ-CRCLSG 22019
                 |..|....|:.||..|.   |.|..::.||  |.|  ..:.:|  .|.|:|.: || ||.
  Fly   346 RRPDTAFQRYRNSRLGGEFHSE---ITGRSLSECL--DECLRQTSFQCRSAVYSDRFRTCR-LSR 404

  Fly 22020 YRGNPYERCRVI---------------------------GCSSNNDCPTDKTCQNEQCVNPCVYH 22057
            |  |..:..|:|                           |.||:...|.|::..|.:..|.   |
  Fly   405 Y--NQKDGMRIIYDADYDYYENLMLNVVGGGADGDGGGHGGSSDGKRPGDQSGSNWRQPNK---H 464

  Fly 22058 NP--CAPRAECRAQNHLAV----CRCP----VDFLGNPYVDCRPPPQPICQLDTDCPGRQACINE 22112
            :.  .:..:.....:|...    .|.|    ||: |.|| |..|          |..|.:...| 
  Fly   465 DDRYGSGGSSVGGGSHGGTGSGGSRLPPGEGVDY-GRPY-DRYP----------DIAGNEYDRN- 516

  Fly 22113 QCVDPCVVLEPCQRPAICEVTPTSPVRTMLCICPDGYVSRGKGGCKPTPGIKEVGGCISDSDCPT 22177
                                 |....|......||.|.||     .||      ||.....:.|.
  Fly   517 ---------------------PYGGDRDRDRYPPDRYGSR-----YPT------GGDGIGYNRPY 549

  Fly 22178 DKSCLNSVCRDPCNCGLNAEC---RIKDHKPVCTCRQGFEG------------------------ 22215
            |: ..:...|.|...|:|.:.   |.:|..||...|..:.|                        
  Fly   550 DR-FPDDYDRYPAGAGVNGDRDRERDRDRYPVVGDRDRYPGAVDRDRYPGVRDRDRYPEPYPPER 613

  Fly 22216 ---------NPEFECSK---------------IECSINSDCPGTHVCRNQLCIP----ACQGEQC 22252
                     .||.|..:               .:.|:.||.|.|.........|    ...|.:.
  Fly   614 YADRYGDRRYPERERDRDRDRLPYRPLPYPGINDNSLPSDLPHTRPYPTDDDAPFRPYGYGGGRY 678

  Fly 22253 GSNAQCLAIEHRAVCECIPGHGGNARIACTPLGCRSDDECP----TDKACVNGKCNDPCTTTALC 22313
            |.|    ..|.|......|....:      |:|..:..:.|    .|:.......:.|       
  Fly   679 GEN----RYEGRYPPRFPPSRERD------PVGGYTGRDAPDSIFPDRRYRPSSMDSP------- 726

  Fly 22314 AQDELCKVYHHRPQCACPPGTVPGKNGCESERHIPICISDADCPSQKACLRGECVNPCNATQPCG 22378
                   .|.:.|....|||           |:..| :..|..|...:..|    .|.....|.|
  Fly   727 -------RYPYLPDSRGPPG-----------RYDDI-VHSARRPEPDSAKR----YPPAPIAPTG 768

  Fly 22379 VNA-FCSVRDTLPVRTMICECLEGYTGNPAVQCDKRSLCVIEKG--------------------- 22421
            .:: :.|..:..||            ||     |:..:.:.:.|                     
  Fly   769 SSSKYASTPNRFPV------------GN-----DRYPIDIYKYGNRPGPNDLGRRPGLERPPPPF 816

  Fly 22422 ---------------FVRDVDGQCVCPPG----TALDIYEYCTPCREEQGFRIDESGHCVCALER 22467
                           :.|:.||    |||    :......|.:|.....|               
  Fly   817 YDYDYEERYGDRYGPYDREYDG----PPGRRPPSGGPYGRYDSPFNRPYG--------------- 862

  Fly 22468 GMVIDERGRCTCPIDLGYRLTPRG-------------ECQPEEPP--ECTSNDQCADNRFCNLDT 22517
            |..:|:|......:.|.:..||.|             ...|..||  .|..:|     .|..:..
  Fly   863 GNGLDDRPLPLPGLGLSHPPTPYGGGGAGHVGVGVGVNSGPPRPPITRCEESD-----NFKQIAA 922

  Fly 22518 K------------------TCEDPCLTKVCGVNAFCNAVNHR------------------AQCQC 22546
            :                  .||..|:.   ..:..|.:.|:|                  ..|:.
  Fly   923 RHKMRRHFVRRALIVPSLIQCERECIE---SRDFVCRSFNYRDSAASGYEDRDRDRDRDSPNCEL 984

  Fly 22547 ITGYTGNPDLH------CNHTNF------RTDFPRPDMVVSCLADGVQVEIHITEPGFNGVLYVK 22599
            ....:...|:|      .::.:|      |:|....|:..:|..:|::..|. |..||.|.:|..
  Fly   985 SDRDSRELDIHDPGTFDASNYDFYERSIGRSDGECMDVTQTCNEEGMEFTIR-TPEGFLGRIYTY 1048

  Fly 22600 GHSKDEEC--------RRVVNLAGETVPRTEIFRVHFGSCGMQAVKDVASFVLVIQKHPKLVTYK 22656
            |..  :.|        ..|:.|:|   |:      .:..||.|...|..:.::|:|....:.|.:
  Fly  1049 GFY--DRCFFRGNGGTVNVLRLSG---PQ------GYPDCGTQRYGDTLTNIVVVQFSDNVQTSR 1102

  Fly 22657 AQAYNIKCVYQ-TGEKNVTLGFNVSMLTTAGTIANTGPP-PI----------CQMRI-ITNEGEE 22708
            .:.||:.|::: .||..|:.|:       .|  |.:|.| ||          .::|: |..:|..
  Fly  1103 DKRYNLTCIFRGPGEAVVSSGY-------IG--AGSGSPIPIEYLPAENTLSSKVRLSILYQGRP 1158

  Fly 22709 INSAEIGDNLKLQVDVEPA--TIYGGFARSCIAKTMED--NVQNEYLVTDENGCATDTSIFGNWE 22769
            ..:..:||.|..:::.:..  .:...||.:.:|:....  ::|    :.|..||..|..:|...:
  Fly  1159 TTTIAVGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQ----LIDRFGCPVDPFVFPELD 1219

  Fly 22770 YNPDTNSLLASFNAFKFPSSDNIRFQCNIRVCFGRCQPVNCGG-----YNAFGRRRRSIADNST- 22828
            ...|.::|.|.|||||.|.|:.:.|:..:|.|...|||..|.|     ..:|||||||:  |:| 
  Fly  1220 KLRDGDTLEARFNAFKIPESNFLVFEATVRSCREGCQPAYCPGPAGRQEPSFGRRRRSL--NTTE 1282

  Fly 22829 ----DATAIATNSGVEGQLREEITISSNAILTFEKRSGQ-GLNDANI--------KPAAQR---- 22876
                :|.|:..:|.:|....:|:|:.::.  |.....|| .||:..:        :|...|    
  Fly  1283 IPEPEALALEGSSQLEASTLDEVTVVNST--TVSATLGQVPLNETQLGEKTKETEEPEQVREMIE 1345

  Fly 22877 --------------------VEDICVSMV---GLIIALVITALLALVAVAVAVSCWLMAYRRRPK 22918
                                ||.:|::..   |||.|:::..:|......||.    :.|||..|
  Fly  1346 VFETREEIEKESYPRKLVAPVETVCMTPAEYHGLITAIILLMILLFSITLVAG----LGYRRYWK 1406

  Fly 22919 TIA 22921
            :|:
  Fly  1407 SIS 1409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579 65/259 (25%)
Zona_pellucida <22714..22810 CDD:278526 28/99 (28%)
nompANP_524831.2 PAN_AP_HGF 150..231 CDD:238532 26/172 (15%)
PAN_AP_HGF 244..>303 CDD:238532 16/103 (16%)
PAN_AP_HGF 349..424 CDD:238532 24/82 (29%)
PAN_AP_HGF 914..1011 CDD:238532 12/104 (12%)
ZP 1025..1264 CDD:214579 67/263 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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