DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and MATN2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_002371.3 Gene:MATN2 / 4147 HGNCID:6908 Length:956 Species:Homo sapiens


Alignment Length:609 Identity:157/609 - (25%)
Similarity:229/609 - (37%) Gaps:178/609 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 GEVFYLNLENGYFGCQVNESTEYLQLFNLSKLCDGTQDCFLGADELSKELKCTNDCDKDGTKCTH 106
            |:|.:..|::  .|.:.:|...:| :.|.|::...|       ....|:|...:.|......|.|
Human   197 GQVDFNTLKS--IGSEPHEDHVFL-VANFSQIETLT-------SVFQKKLCTAHMCSTLEHNCAH 251

  Fly   107 GACLN----GVCHCNDGYGGCNCVDKDENECK-QRPCDVFAH-----CTNTLGSFTCTCFPGY-- 159
             .|:|    .||.|..||    .::.|:..|: |..|.:..|     |.|..|||.|.|:.||  
Human   252 -FCINIPGSYVCRCKQGY----ILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311

  Fly   160 RGNGFHCEDIDECQDPAIAARCVEN----AECCNLPAHFLCKCKDGYE-GDGEVLCTDVDECRNP 219
            ..:|..|..:|.|..        ||    .||.|....:||:|.:|:. ...:..||.:|.|.: 
Human   312 AEDGKRCVAVDYCAS--------ENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCAS- 367

  Fly   220 ENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNLEGSYRCDCPP 284
            .|.|....|.||..:|:|.|..|:. .||.::.|:.::.|:. |..|....|.|:|.||.|.|..
Human   368 SNHGCQHECVNTDDSYSCHCLKGFT-LNPDKKTCRRINYCAL-NKPGCEHECVNMEESYYCRCHR 430

  Fly   285 GY--DGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCLCPDGY-SGDPMNGCEDVDECATNN 346
            ||  |.:|::   |...|.||:...|....||||:.||.|.|.:|: ..:.:..|..||.|..::
Human   431 GYTLDPNGKT---CSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD 492

  Fly   347 PCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLAC 411
            . |....|||:..||.|:||.|.||..|                                 |..|
Human   493 H-GCEYSCVNMDRSFACQCPEGHVLRSD---------------------------------GKTC 523

  Fly   412 LDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHCENINECQDNPCGENAICTDTV 476
            ..:|.|...|.    |....|::...|:.|.|     .:||:..|:...|:..            
Human   524 AKLDSCALGDH----GCEHSCVSSEDSFVCQC-----FEGYILREDGKTCRRK------------ 567

  Fly   477 GSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCENTVPGYNCKCPQGY----DGKPDPKV 537
                                  |.|.|:|..| :| :|.|:...|.|:|.:|:    |||     
Human   568 ----------------------DVCQAIDHGC-EH-ICVNSDDSYTCECLEGFRLAEDGK----- 603

  Fly   538 ACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPG 602
            .|.:.||   |.|                                   ||.   |....|:|...
Human   604 RCRRKDV---CKS-----------------------------------THH---GCEHICVNNGN 627

  Fly   603 SYGCECEAGYVGSPPRMACKQPCE 626
            ||.|:|..|:|.:.....||:..|
Human   628 SYICKCSEGFVLAEDGRRCKKCTE 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 12/35 (34%)
EGF_CA 212..247 CDD:238011 11/34 (32%)
EGF_CA 255..>286 CDD:214542 10/30 (33%)
EGF_CA 298..331 CDD:238011 13/33 (39%)
EGF_CA 338..373 CDD:238011 15/34 (44%)
EGF_CA 413..456 CDD:238011 10/42 (24%)
EGF_CA 457..490 CDD:238011 1/32 (3%)
EGF_CA 497..>529 CDD:214542 11/31 (35%)
EGF_CA 580..>612 CDD:214542 9/31 (29%)
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
MATN2NP_002371.3 vWA_Matrilin 54..276 CDD:238752 22/93 (24%)
FXa_inhibition 283..318 CDD:291342 12/34 (35%)
FXa_inhibition 324..359 CDD:291342 10/42 (24%)
FXa_inhibition 365..400 CDD:291342 12/36 (33%)
FXa_inhibition 406..441 CDD:291342 14/38 (37%)
vWFA <438..481 CDD:294047 15/45 (33%)
FXa_inhibition 488..523 CDD:291342 15/68 (22%)
vWFA <520..563 CDD:294047 13/51 (25%)
vWFA <561..603 CDD:294047 14/77 (18%)
vWFA <602..644 CDD:294047 18/87 (21%)
vWA_Matrilin 652..892 CDD:238752 157/609 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 840..863
Matrilin_ccoil 911..953 CDD:287378
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BA2W
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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