DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and psip1b

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_021325735.1	Gene:	psip1b / 407619	ZFINID:	ZDB-GENE-030131-3273	Length:	1564	Species:	Danio rerio

Alignment Length:	1654	Identity:	298/1654 - (18%)
Similarity:	492/1654 - (29%)	Gaps:	375/1654 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  4440 RVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLET 4504
            |:.||.|..::..:.......|.              :|..:|.:|..:....:|:||...  ||
Zfish   109 RLSESRLKWKNKKKKKAENQTEV--------------KKPPKSAKDPVSNSDSKAATPHKR--ET 157

  Fly  4505 TVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTI--RVEESTLPSRSADRTTLSESPETPTT 4567
            ...||||:...|..        |..|.|..|..:|:.  |..:..:|:|.      ..|.:|.||
Zfish   158 KSESVTLKDDKNTE--------TRPTRSRDSSAKTSTDKRRTDKVVPARK------MTSVKTITT 208

  Fly  4568 ----LPSDF----------TIRPHSE------------------------QTTESTRDVPTTRPF 4594
                |||..          |:..|.:                        :.|.||.|     |.
Zfish   209 GWRRLPSSVILARRMDAAKTLSAHRKHVLNRKIISTAKKRIDAVNHRKPSRITRSTAD-----PI 268

  Fly  4595 EAS---TPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTD 4656
            ||:   |..|.:|:.......||...:.||......::..:|...|:.|.....|:.:.......
Zfish   269 EATDDVTAKPLALKRKRKQNDSEVKGDAPISIPATDISASSTPTGSKRRRLTEPEKKSKDDEKEL 333

  Fly  4657 RTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNV 4721
            :...::|.|...:           :|..|...:|..:   .|........:.....:..|..|.
Zfish   334 KENEAQSKEKNEV-----------EQKIEKQNEVEKS---NADKNKMMEKKNQAEKIVAENETE- 383

  Fly  4722 PIGSTGGQVTEQTTS----SPSEVRTTIRVE-----------ESTLPSRSADRTTPSESPETPTT 4771
               :.|.:..|...|    ..||.:.|.::|           ||..|.::......:|..||..:
Zfish   384 ---NKGAKKKESEKSDAEKEKSEKKETKKIETERKEARNSEAESKEPCKNDSEKKEAERIETRKS 445

  Fly  4772 LPSDFITR-PHSEK--TTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVT 4833
            .....:.: ..|||  |.:|..::...|..|:....:...|:. ...|.::.:.:..........
Zfish   446 ESEVLVAKNKESEKRETRKSESEMKEARKNESKKQEARKSESE-KRETRKSESEMKEARKNESEM 509

  Fly  4834 EQTTSSPSEVRTTIRVEESTLPSRSAD------RTTPSESPETPTTLPSDFITRPHSEKTTESTR 4892
            ::...|.||.|.|.:.|...:.:|..:      |.:.||..||           .:||...:..|
Zfish   510 KEARKSESEKRETRKSESEMIEARKNESEMKEARKSESERRET-----------KNSEAEIKEAR 563

  Fly  4893 DVPTTRPFEASTPSSASLETTVPSVTLETTTNV----PIGSTGGQVTE--QTTSSPSEVR-TTIR 4950
              ......||...:|...||......:|...|.    ..|.:..::.|  :..|...|.| ...|
Zfish   564 --KNESEIEAIRSNSEKRETRKSDSEMEAKNNESEKREAGKSESEMKEARKNESEKKEARKRETR 626

  Fly  4951 VEESTLPSRSTDRTTPSESPETPTTLPSDF----TTRPHSE-----------QTTESTRDVPTTR 5000
            ..||.:.......|..||| |......:|.    ||:..||           :..:|..::...|
Zfish   627 KSESDMKEAKRKETRKSES-EIKVAKDNDSEKRETTKNESEIEAKNKESEKREAGKSESEIKEAR 690

  Fly  5001 PFEASTPSPASLETTVPSVTL----ETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSR 5061
            ..|:........||......:    :..:.:.:.........:|..:..|:.|.....|     :
Zfish   691 KNESEKEEARKRETRKSESDMKEARKNESEIKVAKDNDSEKRETRQNEFEIETKNNESE-----K 750

  Fly  5062 SADRTTPSESPETPTTLPSDFITRTYSDQTTESTRDVP---TTRPFEASTPSPASLETTVPSVTS 5123
            ...|.:.||..|...| .|:.|....::...||.||..   .||..|:........|:...::.:
Zfish   751 RETRKSESEMKEARKT-DSEIIEAKKNESEKESKRDESEKRETRKNESEMKEARKNESEKRAIRN 814

  Fly  5124 ETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTD------RTTPSESPETPTTLPS 5182
            |        |...:...|:....||.|....:|.....::..|      |...||..|
Zfish   815 E--------SEKRETKSQSEIKESEKREARNIESEKKEAKKIDSEMKQARKNESEKKE------- 864

  Fly  5183 DFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSS 5247
               .|....:..|:.|                          :|              |.:|.|.
Zfish   865 ---ARKSESEKKEAER--------------------------VE--------------TRKTESE 886

  Fly  5248 PSEVRTT--------IRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPAT 5304
            ..|||.:        .::|..:...|...:.:.||:.|.....|:......||...:..|...:.
Zfish   887 KKEVRKSESEKKEAERKLERKSESERKEAKKSESENKEARGNESEKKGARRSESEKKEARQSESE 951

  Fly  5305 RPFEASTPSPASLETTVPSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSR--- 5366
            :.....:.|.........|...||..|        :..::.|.|.||.|.|.|.|......|
Zfish   952 KKEARRSESEKRENRRSESEKKEARRN--------ESEKRETRSESEKRETRRNESEKREPRWRE 1008

  Fly  5367 -STDRTSPSESPETPTTLPSDFTTRPHSD------QTTECTRDVPTTRPFEASTPSSASLETTVP 5424
             ....|...||.:..|.........|.|:      :.:|..:.......||......:..|....
Zfish  1009 SEKKETRRRESEKKETRRSESEKKEPRSESKKKEARRSESEKKEARRSEFEKKEARRSEFEKKEA 1073

  Fly  5425 SVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTT------IRVEESTLPSRSA------------- 5470
            .::...........:..:...::.....|.|.:      .|:.||....||.
Zfish  1074 RMSESDKKEAKRNESEKKEARRSEFEKKEARRSEFEKKEARMSESEKARRSEFEKKEARRNESEK 1138

  Fly  5471 --DRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTT 5533
              .|...||..|.....|: .....||...:..|...:.:.......|....|..:.|...|...
Zfish  1139 KDARRNESEKKEARRNESE-KKEARSESEKKEARRNESEKNEGRRNESEKKEERRIESEKKEARK 1202

  Fly  5534 NVPIGSTGGQVTEQTTSSPSEFRTTIRVEESTLPSR------SADRTTPSESPETPTLPSDFTTR 5592
            |        :..::...|.||.:...|.|.....:|      ..:|...||..|.....|:...|
Zfish  1203 N--------KSEKEARRSDSELKEARRKESELKEARRNESEKKEERRIESEKKEARKNKSEKEAR 1259

  Fly  5593 PHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVR 5657
            ....:..|:.|.....:....:....:..|.............:|                 |.|
Zfish  1260 RSDSELKEARRKESELKEARRNESVKSDAEKDAVEKNKAEKNKLP-----------------EKR 1307

  Fly  5658 TTIRVEESTLPSRSTDRTTPSESPETPTILP--SDSTTRTYSDQTTESTRDVPTTRPFEASTPSP 5720
            ..|.|||.        |.|.::..:|.:..|  ||.|......:..|..:.:...|
Zfish  1308 KEINVEER--------RETMTKPKQTKSCAPVSSDETQEEKKPRDEERCKILAEKR--------- 1355

  Fly  5721 ASLETTVPSVTLETTTNVPIGSTGGQVTGQTTAT--PSEVRTTIGVEESTLPSRSTDRTSPSESP 5783
            .|:..::..:...|....|.||.      |||.|  |.:.|.....:.:....:.|::....|..
Zfish  1356 QSVLKSLQGLVTSTRGKTPSGSE------QTTETKEPRKERNHRLKQPAEDEKKDTEKRKEQEKR 1414

  Fly  5784 ETPTTLPS--DFTTRPHSDQTTEST-----RDVPTTRPFEASTPSPASLETTVPSVTS-----ET 5836
            .|...:.|  :...|.||...|:|.     .|:..:...|.            |.|:.     :.
Zfish  1415 NTEQQISSSKEEERRAHSLSVTDSLLYRLHGDIRISMTLEN------------PDVSKCLSALDE 1467

  Fly  5837 TTNVPIGSTGGQVTEQTTSSPSEVRTTIGLE-----ESTLPSRSTDRTSPSESPETPTTLPSDFI 5896
            .:|||:.|...|...:...:..::|...|.|     .|.|..|..:.....::.|   ||..::|
Zfish  1468 LSNVPVSSRNIQNHSELIDTLRKMRWFRGSEAIMFKASMLYHRFKNIYLIGDADE---TLSQEYI 1529

  Fly  5897 T---RPHSDQTTESTRDVPTTRPFEASTP 5922
            .   :....:..|..||...|......||
Zfish  1530 NSLQQEREREIEERHRDAVRTEADVRKTP 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	55/280 (20%)
		DUF4758	4275..4448	CDD:292572	4/7 (57%)
		DUF4758	4377..4574	CDD:292572	33/149 (22%)
		DUF4758	4581..4754	CDD:292572	35/190 (18%)
		DUF4758	4683..4847	CDD:292572	31/181 (17%)
		DUF4758	4785..4964	CDD:292572	36/191 (19%)
		DUF4696	4841..5385	CDD:292395	112/596 (19%)
		DUF4758	4887..5098	CDD:292572	45/236 (19%)
		DUF4758	5193..5371	CDD:292572	32/189 (17%)
		DUF4758	5294..5487	CDD:292572	36/223 (16%)
		DUF4758	5445..5650	CDD:292572	36/231 (16%)
		DUF4758	5700..5877	CDD:292572	37/195 (19%)
		DUF4696	5756..6396	CDD:292395	35/187 (19%)
		DUF4758	5802..5979	CDD:292572	27/139 (19%)
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
psip1b	XP_021325735.1	HDGF_related	14..93	CDD:99895
		Neuromodulin_N	<221..921	CDD:331332	138/801 (17%)
		Neuromodulin_N	<586..1321	CDD:331332	143/841 (17%)
		LEDGF	1440..1534	CDD:314400	19/108 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910