DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and Notch4

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001002827.1 Gene:Notch4 / 406162 RGDID:1303282 Length:1961 Species:Rattus norvegicus


Alignment Length:2911 Identity:620/2911 - (21%)
Similarity:864/2911 - (29%) Gaps:1197/2911 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 PCDVFAHCTN-TLGSFTCTCFPGYRGNGFHCEDIDECQ--DPAIAARCVENAECCNLPAHFLCKC 198
            ||.....|.. :.|..||.|.||:.|        :.||  ||                       
  Rat    31 PCANGGTCLRLSQGQGTCQCAPGFLG--------ETCQFPDP----------------------- 64

  Fly   199 KDGYEGDGEVLCTDVDECRNPENCG---PNALCTNTP-----GNYTCSCPDGYVGNNPYREGCQD 255
                       |.|...|.|..:|.   |.|..:::|     .:::|:||.|:.|:.     ||.
  Rat    65 -----------CWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTCPSGFTGDR-----CQS 113

  Fly   256 -VDECSYPNVCGPGAICT-NLEGSYRCDCPPGYDGDGRSESGCVDQDECARTPCGRNADCLNTDG 318
             ::|...|:.|..|..|: .:.|..:|.|.||:.|:     .|..:|.|:..||.....||.|..
  Rat   114 PLEELCPPSFCSNGGHCSVQVSGRPQCSCEPGWTGE-----QCQLRDFCSANPCANGGVCLATYP 173

  Fly   319 SFRCLCPDGYSGDPMNGCE-DVDECATN-NPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLP 381
            ..:|.||.|:.|   :.|| ||:||... .||..|..|.|..|||||.||.|             
  Rat   174 QIQCRCPTGFEG---HICERDVNECFLEPGPCPRGTSCHNTLGSFQCLCPVG------------- 222

  Fly   382 QPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCIN------FPGS-- 438
                 |:   ||                      :|....|....||   |:|      .|..  
  Rat   223 -----QE---GP----------------------QCKLRKGACLPGT---CLNGGTCQLVPEGDT 254

  Fly   439 --YRCLCPSGFQGQGYLHCE-NINECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDE 500
              :.||||.||.|   |:|| |.::|..|.|...|.|.|.:|::.|.|...:.|  :....||||
  Rat   255 TFHLCLCPPGFTG---LNCEMNPDDCVRNQCQNGATCQDGLGTYTCLCPKTWKG--WDCSEDIDE 314

  Fly   501 CTALDKP-CGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQ 564
            |.|...| |.....|:|:..|::|.|..|:.|:.              |..|.|     :|....
  Rat   315 CEAQGPPRCRNGGTCQNSAGGFHCVCVSGWGGEG--------------CDENLD-----DCAAAT 360

  Fly   565 CFCLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVG---SPPRMACKQPCE 626
            |       .:||:|:|                   ..||:.|.|..|..|   ....|..:|||.
  Rat   361 C-------ALGSTCID-------------------RVGSFSCLCPPGRTGLLCHLEDMCLRQPCH 399

  Fly   627 DVRCGAHAYC--KPDQNEAYCVCEDGWTYNPSDVAAGC-VDIDECDV-MHGPFGSCGQNATCTNS 687
                 .:|.|  .|......|:|:.|:: .|:     | .|:|||.: ..|| ..|....:|.|:
  Rat   400 -----VNAQCSTNPLTGSTLCICQPGYS-GPT-----CHQDLDECQMAQQGP-SPCEHGGSCINT 452

  Fly   688 AGGFTCACPPGFSGDPHSKCVDVDECRTGASKCGAG-AECVNVPGGGYTCRCPGNTIADPDPSVR 751
            .|.|.|.|.||::|                |:|.|. .||::.|     |. ||:|         
  Rat   453 PGSFNCLCLPGYTG----------------SRCEADHNECLSQP-----CH-PGST--------- 486

  Fly   752 CVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPG 816
            |:.::               ||.:||||                                   ||
  Rat   487 CLDLL---------------ATFQCLCP-----------------------------------PG 501

  Fly   817 YTGNSALAGGCN-DIDECRANPCAEKAICSNTAGGYLCQC-PGGSSGDPYREGCITSKTVGCSDA 879
            ..|..     |. :|:||.:|||..:|.|.:...|:||.| ||                      
  Rat   502 LEGRL-----CEVEINECASNPCLNQAACHDQLNGFLCLCLPG---------------------- 539

  Fly   880 NPCATGETCVQDSYTGNSVCICRQGYERNSENGQCQ-DVDECSVQRGKPACGLNALCKNLPGSYE 943
                         :||                .:|: |:||||    ...|.....|::.||::.
  Rat   540 -------------FTG----------------ARCEKDMDECS----SAPCANGGHCQDQPGAFH 571

  Fly   944 CRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAECISIAGGVSYCAC 1008
            |.|..|..|      ..|.|...:|:|                 ..||.||.|:.:.|.. .|.|
  Rat   572 CECLPGFEG------PRCETEADECRS-----------------DPCPVGASCLDLPGAF-LCLC 612

  Fly  1009 PKGYQTQPDGSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRKCAA 1073
            ..|:    .|...:|..|   ...||..|.||.::.....|.||:|..|      |.      .|
  Rat   613 RPGF----TGQLCEVPLC---SPILCQPGQQCQDQEHRAPCLCPDGSPG------CV------PA 658

  Fly  1074 DRECAANEKCIQPGECVCPPPYFLDPQDNNKCKSP---CERFPCGINAKCTPSDPP-QCMCEAGF 1134
            :.:|..:....|...|||...:     ...:|::.   |...||.....|.|.... .|.|.||:
  Rat   659 EDDCPCHHGHCQRSLCVCNEGW-----TGPECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGY 718

  Fly  1135 KGDPLLGCTDE-DECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSND 1198
            .|   |.|::| ..|...||..|..|.....||.|.||..:|| |:....:             |
  Rat   719 TG---LTCSEEITACHSGPCLNGGSCSIHPEGYSCTCPPSHTG-PHCQTAV-------------D 766

  Fly  1199 DCASNLACLE-GSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQDVICGDGA 1262
            .||| .:||. |:|:|...:..|    :|.|......|..::.          ..|.|..|.:.|
  Rat   767 HCAS-ASCLNGGTCMSKPGTFFC----HCATGFQGLHCEKKIH----------PSCADNPCRNKA 816

  Fly  1263 LCIPTSEGPTCKCPQGQLGNPFPGGSCST--DQCSAARPCGERQICINGRCKERCEGVVCGIGAT 1325
            .|..|..|..|.|..|     :.|.||.|  |.| |.:||.....|:..             |.:
  Rat   817 TCQDTPRGARCLCSPG-----YTGSSCQTLIDLC-ARKPCPHTARCLQS-------------GPS 862

  Fly  1326 CDRNNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGENAHCEYGLGQSRCACNPGTFGNPYEGCG 1390
            .     .|:|...:.|:   :|..|:                        :|.......     |
  Rat   863 F-----HCLCHQGWTGS---LCDLPL------------------------SCQAAAMSQ-----G 890

  Fly  1391 AQSKNVCQPNSCGPNAECRAVGNHISCLCPQGFSGNPYIGCQD-VDECANKPCGLNAACLNRAGG 1454
            .:..|:||....     |...|:...|.||.||.|..   ||| |:.|.:|||...|.|:.:..|
  Rat   891 VEISNLCQNGGL-----CIDTGSSYFCRCPPGFEGKL---CQDTVNPCTSKPCLHGATCVPQPNG 947

  Fly  1455 FECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECPEGYSCQKGQCKNLCSQASCGPRAIC 1519
            :.|.|..|:.|   .:|..:..                     :||.|.|.|   ..:|.||.  
  Rat   948 YVCQCAPGYEG---QNCSKVHD---------------------ACQSGPCHN---HGTCTPRP-- 983

  Fly  1520 DAGNCICPMGYIGDPHDQVHGCSIRGQCGNDADCLHSEICFQLGKGLRKCVDACSKIQCGPN--A 1582
            ...:|.||.|::|          :|  |..|.|               :|:|.    .|.|:  |
  Rat   984 GGFHCACPPGFVG----------LR--CEGDVD---------------ECLDR----PCHPSGTA 1017

  Fly  1583 LCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEEEDKCKSDQDCSRGYGCQASVNGIKECIN 1647
            .|.|..:...|.|..|..|.      .|:.|.      |.|:| |.||.|..|:           
  Rat  1018 SCHSLANAFYCQCLPGHTGQ------RCEVEM------DLCQS-QPCSNGGSCE----------- 1058

  Fly  1648 LCSNVVCGPNELCKINPAGHAICNCAESYVWNPVVSSCEKPSLPDCTSDANCPDASACRPDVLGV 1712
                |..||       |.|.. |.|.|.:            ..|.|:.     .|.||       
  Rat  1059 ----VTTGP-------PPGFT-CRCPEGF------------EGPTCSR-----KAPAC------- 1087

  Fly  1713 LKCVAICDAFTCPANSVCVARQHQGRCDCLNGFVGNPNDRNGCQPAQKHHCRNHAECQESEACIK 1777
                                              ||            |||.|...|..|     
  Rat  1088 ----------------------------------GN------------HHCHNGGLCLPS----- 1101

  Fly  1778 DESTQTLGCRPACDTVKCGPRAVCVTNNHQAQCQCPPGPFAGDPYDPFNGC-QSVPCVYNHDCPP 1841
                ...|..|.|         .|::......|..||.|         .|| ...||::|..|  
  Rat  1102 ----PKPGSPPLC---------ACLSGFGGPDCLTPPAP---------PGCGPPSPCMHNGSC-- 1142

  Fly  1842 SQMCNRMTHTCFDVCDEESCGDNAICLAEDHRAVCQCPPGFKGDPLPEVACTKQGGCAAGTCHPS 1906
                   |.|       ...|:                |||:              |   ||.|.
  Rat  1143 -------TET-------PGLGN----------------PGFQ--------------C---TCPPD 1160

  Fly  1907 AICEVTPEGPVCKCPPLFVGDAKSGGCRPDGQCPNGDADCPANTICAGGVCQNPCDNACGSNAEC 1971
            :      .||.|:.|       .:.||...|    ||..|.|.       |..|..:..|  .:|
  Rat  1161 S------PGPRCQRP-------GANGCEGRG----GDGACDAG-------CSGPGGDWDG--GDC 1199

  Fly  1972 KVINRKPVCSCPLRFQPISDTAKDGCARTISKCLTDVDCGGALCYNGQCRIACRNSQDC-SDGES 2035
            .:....|...||..                |:|       ..|..:|:|...| :|::| .||..
  Rat  1200 SLGVPDPWKGCPPH----------------SQC-------WLLFRDGRCHPQC-DSEECLFDGYD 1240

  Fly  2036 C-LKNVCVVA----CLDHSQCASGLACVEGHCTIGCRSNKECKQDQSCIENKCLNPCQSANSCGP 2095
            | :...|..|    |.||..        .|||..||.                            
  Rat  1241 CEIPPTCTPAYDQYCRDHFH--------NGHCEKGCN---------------------------- 1269

  Fly  2096 NALCSIDQHHSQCSCPEGFEGNPTPEQGCVRVPAPCLASNQCPSGHMCIGNQCNL---------- 2150
            ||.|..|  ...|. |||.:....|....:.|.:|.....|.    :.:....:|          
  Rat  1270 NAQCGWD--GGDCR-PEGDDSEGGPSLALLVVLSPPALDQQL----LALARVLSLTLRVGLWVRK 1327

  Fly  2151 -----------PCTKTASCAVGERCYQQVCRKVCYTSNNCLAGEICNSDRTCQPGCDSDADCPPT 2204
                       |.|:......|.|......|:..:|..               ||.::::     
  Rat  1328 DSEGRNMVFPYPGTRAKEELSGTRDSSSWERQAPHTQT---------------PGKETES----- 1372

  Fly  2205 ELCLTGKCKCATGFIGTPFGCSDIDECTEQPCHASARCEN---------------------LPGT 2248
                     ...||: ...|. |:..|  .|.|.::||..                     |||.
  Rat  1373 ---------LGAGFV-VVMGV-DLSRC--GPEHPASRCPRDSGLLLRFLAAMAAVGALEPLLPGP 1424

  Fly  2249 YRCVCPEGTVGDGYSQPGCSQPRQCHKPDDCANNLACIHGKCTDPCLHTVCGINA-------NCQ 2306
            .....|:.    |...|....|    .|..|:..:..:           :..:.|       ..:
  Rat  1425 LLAAHPQA----GTGSPATRLP----WPILCSPVVGVL-----------LLALGALLVLQLIRRR 1470

  Fly  2307 SEGHEALCSCPAGFLGDP---------------NDTGVGCFKVEC-IDH---VDCAGDRACDAET 2352
            ...|.||. .|.||:..|               ::.|:...|.|. :|.   |.|:|....:||.
  Rat  1471 RREHGALW-LPPGFIRRPQTQQAPHRRRPPLGEDNIGLKALKPEAEVDEDGVVMCSGPEEGEAEK 1534

  Fly  2353 NRCIKPCDLTSCGKGNCQVRDHKATCACYEGYQLVNDVCEDINECL----SQPCHSTAFCNNLPG 2413
            ......|.|.....|                       ||.:.:.:    .|.|.|     .||.
  Rat  1535 TASASRCQLWPLRSG-----------------------CEGLPQAVMLTPPQECES-----ELPD 1571

  Fly  2414 SYSCQCPEGLIGDPLQA-----------------GCRDPNECLSDADCPASASCQNSRCRSPCER 2461
            |.:|. |:|:  .||.:                 |..:|.|.|.|              |..|.:
  Rat  1572 SDTCG-PDGV--TPLMSAVFCGGVQSTTVQRLGLGNPEPWEPLLD--------------RGACPQ 1619

  Fly  2462 QNACGLNANCQAQAHQAICTCPLN-----SRGDPTIECVHIECADNDDCSGEKACLDSKCIDPCS 2521
            .:..|....            ||:     ||  ||.....:|...|                   
  Rat  1620 AHTVGTGET------------PLHLAARFSR--PTAARRLLEAGAN------------------- 1651

  Fly  2522 LPNACGALARCSVQNHIGVCSCEAGSTGDAKLGCVQLQYCQQ---DGQCAQGSICSHGICSPLCS 2583
             ||......|..:  |..|.:       ||:..|..|...:|   |.:...|:       :||..
  Rat  1652 -PNQPDRAGRTPL--HTAVAA-------DAREVCQLLLASRQTAVDARTDDGT-------TPLML 1699

  Fly  2584 TNR----DCISEQLCLQGVCQGTCKSNSSCPQFQFCSNNI----CTKELECRSDSECGEDETCLS 2640
            ..|    |.:.|.:..:.......|...:...:....||.    |..:.....|::...::|.|.
  Rat  1700 AARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARCLLQTGADKDAQDSREQTPLF 1764

  Fly  2641 DAYGRAKCESVCLGRAACGRNAECVARSHAPDCLCKEGFFGDAKSGCRKIECTSDDDCSNDKSCD 2705
            .|......|...|                    |.:.|    |..|.|.....:..|.:..:|  
  Rat  1765 LAAREGAVEVAQL--------------------LLEIG----AARGLRDQAGLAPADVARQRS-- 1803

  Fly  2706 NHMCKIACLIGQPCGENALCTTEHHQQVCHCQPGFSGDPRVRCDVIDFCRDAPCGP----GARCR 2766
             |...:..|      |.|...|:..:......||....||        ||....|.    |..|.
  Rat  1804 -HWDLLTLL------EGAGPITQEARSHARNTPGGGAAPR--------CRTLSAGARPRGGGACL 1853

  Fly  2767 NA----------RGSY--KCTCPPGLVGDPYNEGCRSSVECE-------TNEDCPPHAACTKTNG 2812
            .|          ||:.  :|....|..|.|...|.|.|.:..       :.:|.|          
  Rat  1854 QARTWSVDLGARRGAVYARCRSRSGGSGGPSMRGRRLSADSRGRRGARVSQDDWP---------- 1908

  Fly  2813 VAKCRDVCAQLQCGPNAECVPKGHVAQCACRSGYDGQPADRVAGCKPLPSP 2863
                ||..|...||             .||.:              |:|.|
  Rat  1909 ----RDWVALEACG-------------SACSA--------------PIPPP 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 10/29 (34%)
EGF_CA 212..247 CDD:238011 12/42 (29%)
EGF_CA 255..>286 CDD:214542 9/32 (28%)
EGF_CA 298..331 CDD:238011 11/32 (34%)
EGF_CA 338..373 CDD:238011 17/35 (49%)
EGF_CA 413..456 CDD:238011 15/52 (29%)
EGF_CA 457..490 CDD:238011 10/32 (31%)
EGF_CA 497..>529 CDD:214542 13/32 (41%)
EGF_CA 580..>612 CDD:214542 5/31 (16%)
EGF_3 676..702 CDD:289699 9/25 (36%)
EGF_CA 1022..1056 CDD:214542 11/33 (33%)
EGF_CA 2227..2260 CDD:238011 10/53 (19%)
EGF_CA 2393..>2422 CDD:214542 8/32 (25%)
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Notch4NP_001002827.1 EGF_CA 191..>224 CDD:284955 17/50 (34%)
EGF_CA 311..349 CDD:238011 15/51 (29%)
EGF_CA 352..387 CDD:238011 14/65 (22%)
EGF_CA 429..470 CDD:238011 17/57 (30%)
EGF_CA 472..508 CDD:238011 17/105 (16%)
EGF_CA 511..546 CDD:238011 16/85 (19%)
EGF_CA 548..584 CDD:238011 13/45 (29%)
EGF_CA 588..622 CDD:238011 12/55 (22%)
EGF_CA <696..723 CDD:238011 10/29 (34%)
EGF_CA 765..800 CDD:238011 12/52 (23%)
EGF_CA <810..839 CDD:238011 10/33 (30%)
EGF_CA 892..924 CDD:238011 11/39 (28%)
EGF_CA 927..961 CDD:238011 12/36 (33%)
EGF_CA 966..1000 CDD:238011 14/71 (20%)
EGF_CA 1002..1040 CDD:238011 13/62 (21%)
Notch 1207..1242 CDD:278494 12/58 (21%)
Notch 1245..1281 CDD:278494 14/73 (19%)
NOD 1291..1337 CDD:284282 5/49 (10%)
NODP 1376..>1415 CDD:284987 9/42 (21%)
Ank_2 <1571..1656 CDD:289560 24/135 (18%)
ANK 1625..1732 CDD:238125 26/156 (17%)
ANK repeat 1626..1656 CDD:293786 10/63 (16%)
Ank_2 1630..1723 CDD:289560 24/130 (18%)
ANK repeat 1658..1690 CDD:293786 9/40 (23%)
ANK 1687..1811 CDD:238125 25/157 (16%)
ANK repeat 1692..1723 CDD:293786 6/37 (16%)
Ank_2 1697..1789 CDD:289560 18/115 (16%)
ANK repeat 1725..1756 CDD:293786 4/30 (13%)
ANK repeat 1758..1789 CDD:293786 9/54 (17%)
ANK repeat 1791..1827 CDD:293786 7/44 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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