DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and LTBP2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_000419.1	Gene:	LTBP2 / 4053	HGNCID:	6715	Length:	1821	Species:	Homo sapiens

Alignment Length:	1278	Identity:	364/1278 - (28%)
Similarity:	496/1278 - (38%)	Gaps:	368/1278 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QVNESTEYLQLFNLSKLCDGTQDCFLGADELSKELKCTNDCDKDGTKCTHGACLN---GV-CHCN 117
            ||..||:.|    ::....|...|..||         ||.|..       |.|:|   |. |.|:
Human   829 QVTPSTDVL----VTLSTPGIDRCAAGA---------TNVCGP-------GTCVNLPDGYRCVCS 873

  Fly   118 DGY----GGCNCVDKDENECKQRPCDVFAHCTNTLGSFTCTCFPGY----RGNGFHCEDIDECQD 174
            .||    ....|.  |:|||.:.||.....|.|.:||::|.|:|||    .|....|:||:||:.
Human   874 PGYQLHPSQAYCT--DDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQ 936

  Fly   175 PAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDECRNPENCGPNALCTNTPGNYTC-S 238
            |.:.:    ..:|.|....:.|:|..||....:..|.|::|||:|..| |:..|.|:||:||| :
Human   937 PGVCS----GGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTC-PDGRCVNSPGSYTCLA 996

  Fly   239 CPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECA 303
            |.:||.|.:   ..|.||:||..|.||..|. |||||||:||.|..||:... .|.||.|.||||
Human   997 CEEGYRGQS---GSCVDVNECLTPGVCAHGK-CTNLEGSFRCSCEQGYEVTS-DEKGCQDVDECA 1056

  Fly   304 -RTPCGRNADCLNTDGSFRC-LCPDGY-SGDPMNGCEDVDECATNNPCGLGAECVNLGGSFQCR- 364
             |..|.... ||||:|||.| .|.:|| ..:....|||:||||....|..|. |.|..|||.|:
Human  1057 SRASCPTGL-CLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGV-CTNTAGSFSCKD 1119

  Fly   365 CPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTN 429
            |..|:          .|.||                       |.:|.|:|||..|.  :.| ..
Human  1120 CDGGY----------RPSPL-----------------------GDSCEDVDECEDPQ--SSC-LG 1148

  Fly   430 AKCINFPGSYRCLCPSGFQGQGYLHCENINECQ-DNPCGENAICTDTVGSFVCTCKPDY-TGDPF 492
            .:|.|..|||:||||.|||......||::|||. :..|..:..|.::.|||.|.|.|.: :.:..
Human  1149 GECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGG 1213

  Fly   493 RGCVDIDECTALDKPC-GQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTN 556
            ..|.|:|||...| || |.|  |.||...:||.|..|:...|:
Human  1214 TSCQDVDECATTD-PCVGGH--CVNTEGSFNCLCETGFQPSPE---------------------- 1253

  Fly   557 NAECIENQCFCLDGFEPIGSSCVDIDECRTHAE-VCGPHAQCLNTPGSYGCECEAGYVGSPPRMA 620
                              ...|||||||..:.: |||.. :|.|:||||.|     .:|
Human  1254 ------------------SGECVDIDECEDYGDPVCGTW-KCENSPGSYRC-----VLG------ 1288

  Fly   621 CKQPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDEC--DVMHGPFGSCGQNAT 683
                                      |:.|:...|:   ..|:|||||  |.|      ||.:..
Human  1289 --------------------------CQPGFHMAPN---GDCIDIDECANDTM------CGSHGF 1318

  Fly   684 CTNSAGGFTCACPPGFSGDPHS-KCVDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPD 747
            |.|:.|.|.|.|..||...|.. .||||:||....:.||| |.|.||. |.:.|.|..:......
Human  1319 CDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGA-ALCENVE-GSFLCLCASDLEEYDA 1381

  Fly   748 PSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANG----Q 808
            ....|.|       ....|.|:.:|......|.|.     |..|.:...| ||.|....|    |
Human  1382 QEGHCRP-------RGAGGQSMSEAPTGDHAPAPT-----RMDCYSGQKG-HAPCSSVLGRNTTQ 1433

  Fly   809 AQCLCAPGYTGNSALAGGCNDIDECRANPCAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKT 873
            |:|.|..|.:..          |.|...|..:.|..|..       ||.|....|. ||..|...
Human  1434 AECCCTQGASWG----------DACDLCPSEDSAEFSEI-------CPSGKGYIPV-EGAWTFGQ 1480

  Fly   874 VGCSDANPCAT-GETCVQDSYTGNS----VCICRQGYERNSENGQCQDVDECSVQRGKPACGLNA 933
            ...:||:.|.. |.....:....|:    ||:|..|:..::.:.:|:|.|||.    ..||. |.
Human  1481 TMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ----DLACE-NG 1540

  Fly   934 LCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAECIS 998
            .|.|..||:.|.|      :|.:..::   .:.:|            ::..||.:..|.....:.
Human  1541 ECVNTEGSFHCFC------SPPLTLDL---SQQRC------------MNSTSSTEDLPDHDIHMD 1584

  Fly   999 IAGGV---SYCACP-KGYQTQPDGSCVDVDECE--ERGAQLCAFGAQCVNKPGSYSCHCPEGYQG 1057
            |....   ..|:.| :|::|.....|     |:  |..:|.||.              ||. ...
Human  1585 ICWKKVTNDVCSEPLRGHRTTYTECC-----CQDGEAWSQQCAL--------------CPP-RSS 1629

  Fly  1058 DAYNGLCALAQRKCAADRECAANEKCIQPGECVCPPP----------------YFLDPQDNNKCK 1106
            :.|..||.:|  :..|:||...:   .:||....|.|                .:|.|:|.
Human  1630 EVYAQLCNVA--RIEAEREAGVH---FRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDT---- 1685

  Fly  1107 SPCERFP--CGINAKCTP-------------------SDPPQCMCEAGFKGDPLLGCTDEDECSH 1150
            .|...||  .|.:|..||                   .:||     |||:|      ...:||..
Human  1686 VPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPP-----AGFEG------LQAEECGI 1739

  Fly  1151 LPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDCASNLACLEGSCVSPC 1215
            |.......||..:.||.|.|.:.:..|                       |:::||::   |:.|
Human  1740 LNGCENGRCVRVREGYTCDCFEGFQLD-----------------------AAHMACVD---VNEC 1778

  Fly  1216 SSL-----LCGSNAYCETEQHAGWCRCRVGYV-KNGDGDCVSQ 1252
            ..|     || .:.|||..:.:..|.|..||| :.|...|.::
Human  1779 DDLNGPAVLC-VHGYCENTEGSYRCHCSPGYVAEAGPPHCTAK 1820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	12/32 (38%)
		EGF_CA	212..247	CDD:238011	18/35 (51%)
		EGF_CA	255..>286	CDD:214542	18/30 (60%)
		EGF_CA	298..331	CDD:238011	18/35 (51%)
		EGF_CA	338..373	CDD:238011	15/35 (43%)
		EGF_CA	413..456	CDD:238011	18/42 (43%)
		EGF_CA	457..490	CDD:238011	11/34 (32%)
		EGF_CA	497..>529	CDD:214542	15/32 (47%)
		EGF_CA	580..>612	CDD:214542	15/32 (47%)
		EGF_3	676..702	CDD:289699	10/25 (40%)
		EGF_CA	1022..1056	CDD:214542	7/35 (20%)
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
LTBP2	NP_000419.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..165
		Heparin-binding	94..115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..339
		Heparin-binding	232..249
		Heparin-binding	344..354
		Cell attachment site. /evidence=ECO:0000255	375..377
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544
		EGF_CA	622..>651	CDD:214542
		TB	683..719	CDD:279073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..772
		EGF_CA	887..918	CDD:214542	14/30 (47%)
		EGF_CA	930..>960	CDD:214542	9/33 (27%)
		EGF_CA	970..1005	CDD:238011	18/35 (51%)
		EGF_CA	1010..1041	CDD:214542	19/31 (61%)
		EGF_CA	1051..1091	CDD:284955	18/40 (45%)
		EGF_CA	1093..1133	CDD:284955	19/73 (26%)
		EGF_CA	1135..1175	CDD:214542	18/42 (43%)
		EGF_CA	1176..1217	CDD:214542	11/40 (28%)
		EGF_CA	1218..1257	CDD:284955	17/81 (21%)
		EGF_CA	1303..1335	CDD:238011	16/37 (43%)
		TB	1423..1458	CDD:279073	10/44 (23%)
		EGF_CA	1485..1518	CDD:214542	9/32 (28%)
		TB	1595..1630	CDD:279073	12/54 (22%)
		C-terminal domain. /evidence=ECO:0000269\|PubMed:17293099	1639..1821		52/229 (23%)
		EGF_CA	1774..>1808	CDD:214542	10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11667
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41397
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920