DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and LRP4

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_002325.2	Gene:	LRP4 / 4038	HGNCID:	6696	Length:	1905	Species:	Homo sapiens

Alignment Length:	612	Identity:	140/612 - (22%)
Similarity:	194/612 - (31%)	Gaps:	248/612 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1878 CPPGFKGDPLPEVACTKQGGCAAGTCHPSAICEVTPEGPVCKCPPLFVGDAKSGGCRPDGQCPNG 1942
            |..|....  ||.||    |.:..||..||:.|       |.|
Human    15 CAHGLASS--PECAC----GRSHFTCAVSALGE-------CTC---------------------- 44

  Fly  1943 DADCPANTICAGGVCQNPCDNACGSNAE---CKVINRKPVCSCPLRFQPISDTAKDGCARTISKC 2004
               .||...|.|       ||.||.:::   |.:    |.|| ||.|.  .|..|  |.|....|
Human    45 ---IPAQWQCDG-------DNDCGDHSDEDGCIL----PTCS-PLDFH--CDNGK--CIRRSWVC 90

  Fly  2005 LTDVDCGGALCYNGQCRIACRNSQDCSDGESCLKNVCVVACLDHSQCASGLACVEG--HCTIGCR 2067
            ..|.||                 :|.||.:.|....|..   |...|.:|. |:..  ||.
Human    91 DGDNDC-----------------EDDSDEQDCPPRECEE---DEFPCQNGY-CIRSLWHCD---- 130

  Fly  2068 SNKEC--KQDQSCIENKCLNP---CQSANSCGPNALCSIDQHHSQCSCPEGFEGNPTPEQGC-VR 2126
            .:.:|  ..|:.|...||.:.   |...:....:..|..|     ..|.:|     :.|:.| ..
Human   131 GDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGD-----TDCKDG-----SDEENCPSA 185

  Fly  2127 VPAPCLASNQCPSGHMCIGNQCNLPCTKTASCAVGERCYQQVCRKVCYTSNNCLAGEICNSDRTC 2191
            ||||                .|||   :...||.| ||...:..              |:.|..|
Human   186 VPAP----------------PCNL---EEFQCAYG-RCILDIYH--------------CDGDDDC 216

  Fly  2192 QPGCDSDADCPPTELCLTGKCKCATGF-IGTPFGC---------SDIDECTEQPCHA------SA 2240
            ....| ::||...:.|.:|:..|.:|. |...:.|         ||...||...|.|      |.
Human   217 GDWSD-ESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSG 280

  Fly  2241 RCENLPGTYRCVCPEGTVGDGYSQPGCSQPRQCHKPDDCANN------------------LACIH 2287
            ||..|  ::||        ||              .||||:|                  ..|.:
Human   281 RCVRL--SWRC--------DG--------------EDDCADNSDEENCENTGSPQCALDQFLCWN 321

  Fly  2288 GKCTDPCLHTVCGINANCQSEGHEALCSCPAGFLGDPNDTGVGCFKVECIDHVD------C---A 2343
            |:|.                 |...||:            ||.    :|.|:.|      |   .
Human   322 GRCI-----------------GQRKLCN------------GVN----DCGDNSDESPQQNCRPRT 353

  Fly  2344 GDRACDAETNRCIKPCDLTSCGKGNCQVRDHKATCACYEGYQLVND--VCEDINECLSQPCHSTA 2406
            |:..|:.....|.:.|.:.   :|..|       |.|:.||:|..|  .|:|:||| ::..:.:.
Human   354 GEENCNVNNGGCAQKCQMV---RGAVQ-------CTCHTGYRLTEDGHTCQDVNEC-AEEGYCSQ 407

  Fly  2407 FCNNLPGSYSCQCPEGLIGDPLQAGCR 2433
            .|.|..|::.|.|..|....|.:..|:
Human   408 GCTNSEGAFQCWCETGYELRPDRRSCK 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011	11/38 (29%)
		EGF_CA	2393..>2422	CDD:214542	9/28 (32%)
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
LRP4	NP_002325.2	LDLa	27..66	CDD:238060	17/81 (21%)
		Ldl_recept_a	70..105	CDD:278486	16/56 (29%)
		LDLa	110..142	CDD:238060	9/39 (23%)
		LDLa	148..182	CDD:238060	7/43 (16%)
		LDLa	231..265	CDD:238060	8/33 (24%)
		LDLa	270..304	CDD:238060	15/57 (26%)
		LDLa	311..343	CDD:197566	10/64 (16%)
		FXa_inhibition	358..393	CDD:291342	11/44 (25%)
		EGF_CA	395..434	CDD:214542	11/39 (28%)
		NHL	<471..622	CDD:302697
		NHL repeat	471..507	CDD:271320
		LDL-receptor class B 1	480..522
		LY	505..545	CDD:214531
		NHL repeat	510..550	CDD:271320
		LDL-receptor class B 2	523..565
		NHL repeat	555..589	CDD:271320
		LDL-receptor class B 3	566..609
		LY	590..632	CDD:214531
		NHL repeat	598..622	CDD:271320
		LDL-receptor class B 4	610..652
		LY	633..673	CDD:214531
		LDL-receptor class B 5	653..693
		FXa_inhibition	702..>729	CDD:291342
		LY	766..806	CDD:214531
		LDL-receptor class B 6	785..827
		LY	808..850	CDD:214531
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..911	CDD:278487
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LY	938..979	CDD:214531
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:291342
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		Ldl_recept_b	1179..1219	CDD:278487
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:291342
		LY	1379..1418	CDD:214531
		LDL-receptor class B 16	1397..1439
		LY	1420..1460	CDD:214531
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		Ldl_recept_b	1483..1523	CDD:278487
		LY	1507..1547	CDD:214531
		LDL-receptor class B 19	1527..1568
		LY	1549..1589	CDD:214531
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..>1641	CDD:291342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1659..1686
		Endocytosis signal. /evidence=ECO:0000255	1766..1769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1852..1905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910