DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and MYO18A

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001333694.1	Gene:	MYO18A / 399687	HGNCID:	31104	Length:	2058	Species:	Homo sapiens

Alignment Length:	335	Identity:	73/335 - (21%)
Similarity:	117/335 - (34%)	Gaps:	66/335 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  7073 SSRDVPTTQPFEASTPRPVTLQTAVLPVTSETTTNVPIGSTGGQVT----EQTTSSPSEVRTTIR 7133
            |.|:..|.  .|.|.|.|:.:.:.    :....|::...|..|.|.    ..:|:|.|:   .::
Human    52 SKRESKTR--LEISNPIPIKVASG----SDLHLTDIDSDSNRGSVILDSGHLSTASSSD---DLK 107

  Fly  7134 VEESTLPSRSTDRTTP--SESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPRPVTLE 7196
            .||.:.......|...  |.:.:....:...|:       .::.|||...:   |:|||   :..
Human   108 GEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFS-------FSQRSRDESAS---ETSTP---SEH 159

  Fly  7197 TAVPPVTSETTTNVPIGSTGGQVTEQT---TPSPSEVRTTIRIEESTFPSRSTDRTTPSESPETP 7258
            :|.|      :..|.:.:..||:.:..   .|.|........:....||   .|...|...|..|
Human   160 SAAP------SPQVEVRTLEGQLVQHPGPGIPRPGHRSRAPELVTKKFP---VDLRLPPVVPLPP 215

  Fly  7259 TTLPS-DFTTRPHSDQTTESTRDVPTTRPFESSTPRPVTLEIAVPPVTSETTTNVAIGSTGG--- 7319
            .||.. :...||..|......|.....|..|....|.| :..|.|   ...|.::|:|...|
Human   216 PTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRV-VHFAEP---GAGTKDLALGLVPGDRL 276

  Fly  7320 --------------QVTEQTTSSPSEVRTTIR-VEESTLPSRSTDRTTPSESP-ETPTTLPSDFT 7368
                          ::.|....|...||..:: :.|.:..|||..|:  .|.| ..|:.|.|:..
Human   277 VEINGHNVESKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRS--GEGPRREPSDLDSEAA 339

  Fly  7369 TRPHSDQTTE 7378
            :..||...||
Human   340 SHAHSQAKTE 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572	21/111 (19%)
		DUF4696	7024..7569	CDD:292395	73/335 (22%)
		DUF4758	7172..7383	CDD:292572	54/230 (23%)
		DUF4696	7330..7964	CDD:292395	16/51 (31%)
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Interaction with actin	114..118		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..167		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1469..1499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1871..1920
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910