DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and picalma

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_021334798.1	Gene:	picalma / 393901	ZFINID:	ZDB-GENE-040426-761	Length:	744	Species:	Danio rerio

Alignment Length:	572	Identity:	134/572 - (23%)
Similarity:	206/572 - (36%)	Gaps:	126/572 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  5074 TPTTLPSDFITRTYSDQTTESTRDVPTTRPFEASTPSP---------ASLE------TTVPSVTS 5123
            |..|..|:|:  ..::|......|:|....|....||.         ||||      :|..|..|
Zfish   242 TRMTRISEFL--KVAEQVGIDRGDIPDLSQFTVCAPSSLLDALEQHLASLEGKKVKDSTAASRAS 304

  Fly  5124 ETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTP-SESPE-TPTTLPSDFTT 5186
             |.:|. :.|........|.|...|.:..:..|::.|.:....|... |:.|. |.||..|..:|
Zfish   305 -TLSNA-VSSLANTGISFTKADEREKQAALEEEQARLKALKEQRLKELSKKPSTTSTTAASPVST 367

  Fly  5187 RPHSDQTTESTRDVPTTRPFEASTPS-PASLETTVPSV--TLETTTNVPIGSTGGQVTEQTTSSP 5248
            ...|..|..:......|..|..|||. |..|....|:.  :|..::.:|:.:|.|
Zfish   368 ETGSISTVPAIDLFSATSTFANSTPKVPNDLLDLQPAFQPSLPLSSGLPLANTWG---------- 422

  Fly  5249 SEVRTTIRVEESTLPSRSADRTTPSESP-ETPTLPSD---FTTRPHSEQTTESTRDVPATRPFEA 5309
             :..|:....:.::|:.:...|.|...| ..|.:.||   |::|..|.:......:     ||..
Zfish   423 -DPFTSTEAADDSIPNLNPFLTKPVVDPVHLPVVSSDAVSFSSRTPSHEMFGDNYN-----PFID 481

  Fly  5310 STPSPASLETTVPSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTT--IRVEESTLPSRSTDRTS 5372
            |:.|.||            ....|:|.  |.....:..||:....|  ...|.||:.......::
Zfish   482 SSSSVAS------------PVEPPVGM--GCFLSDSFCSPTAYPNTPLFHSEPSTVAGLFGGFSA 532

  Fly  5373 -PSESPETPTTLPSDFTT---RPHSDQTTECTRDV------PT-TRPFEASTPSSASLETTVPSV 5426
             |:..|.:.|.|..||.:   ......:|:...|:      || |.|.:..|| ||.|...:.|.
Zfish   533 PPAAQPPSSTGLNVDFDSVFGNKSVANSTDSADDILGGILKPTVTSPNQGLTP-SAQLSGKLVSD 596

  Fly  5427 TLETTTNVPIGSTG-GQVTEQTT---SSPSEVRTT--IRVEESTLPSRSADRTT------PSESP 5479
            .|:::....:|:.| |..|.:..   |.|.|.:.|  :..:..|.|:.:.:..|      |..:|
Zfish   597 DLDSSLANLVGNLGIGNGTAKNDIHWSQPGEKKLTGGMNWQPKTAPTTTWNPATMNGMLFPQYAP 661

  Fly  5480 ETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSSASLE-TTVPSVTLETTTNV-----PIG 5538
            .....|:          ||      ||.....|..|...|:. .|.|  |:..|..|     |.|
Zfish   662 SVMAFPA----------TT------PTGMMGYAMPPQMGSMAMMTQP--TMMYTQPVMRPANPFG 708

  Fly  5539 S-TGGQVTEQTTSSPSEFRTTIRVEESTLPSRSADRTTPSESPETPTLPSDF 5589
            . :|.|::  |.||||          |:.|.|:     |.:.|.......||
Zfish   709 PVSGAQLS--TASSPS----------SSSPLRA-----PGQDPFAQLSMKDF 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395	77/337 (23%)
		DUF4758	4887..5098	CDD:292572	5/23 (22%)
		DUF4758	5193..5371	CDD:292572	39/186 (21%)
		DUF4758	5294..5487	CDD:292572	48/217 (22%)
		DUF4758	5445..5650	CDD:292572	38/163 (23%)
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
picalma	XP_021334798.1	ANTH	24..286	CDD:311541	10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910