back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and LanA

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster

Alignment Length:	2417	Identity:	510/2417 - (21%)
Similarity:	702/2417 - (29%)	Gaps:	931/2417 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  9441 GARCEVLNHNPICSCEANFEGDPFVACSPIQDPGRDIPVPKNP-------CVPSPCG--PNSIC- 9495
            |.||....|...|                      |:..||:|       |....||  .|..|
  Fly   270 GGRCMCNGHADTC----------------------DVKDPKSPVRILACRCQHHTCGIQCNECCP 312

  Fly  9496 -----QIKQN---RPV----CSCVANYIGSPPYCRPECTLSSECPSDKACINEK----------- 9537
                 :.:||   ||.    |:|..:              |:||..|:. :|.|
  Fly   313 GFEQKKWRQNTNARPFNCEPCNCHGH--------------SNECKYDEE-VNRKGLSLDIHGHYD 362

  Fly  9538 ----CQNPCANVCGHNARCTVIAHSAHCSCDEDYEGDAFIGCSKKITERPGDHIDPCYPNPCAEN 9598
                |||     |.||        :...:|::         |..|.....|.|.:        |.
  Fly   363 GGGVCQN-----CQHN--------TVGINCNK---------CKPKYYRPKGKHWN--------ET 397

  Fly  9599 AVCTPYNNAARCTCIEPYNGDPYSTGCRPECIYSSECPSSLACIKQHCRDPCTAACGANAECTVV 9663
            .||:|      |.|  .|.   :|||                    ||.:..     .|.||...
  Fly   398 DVCSP------CQC--DYF---FSTG--------------------HCEEET-----GNCECRAA 426

  Fly  9664 NHLPSC-SCTRGFEGNPFDGCKRVVVVRPETVCEPNPCGPNSICRSVEGHPTCSCQVGYFGA-PP 9726
            ...||| ||..|:.|.|  .|:.         ||.|..|.|......|....|.|::.:.|| ..
  Fly   427 FQPPSCDSCAYGYYGYP--NCRE---------CECNLNGTNGYHCEAESGQQCPCKINFAGAYCK 480

  Fly  9727 QCR------PECVVSSECAQHLSCINQKCMDPCVGTCGFNAKCQVN---------NHN----PIC 9772
            ||.      ||| .:.|| ..:..|...| :...|.|    ||..|         .|.    |.|
  Fly   481 QCAEGYYGFPEC-KACEC-NKIGSITNDC-NVTTGEC----KCLTNFGGDNCERCKHGYFNYPTC 538

  Fly  9773 S-CPANYEGNPFEQCMPKPAEPTRNVDPCLPSPCGSNSICRNVNNRAEC-SCAPGMFGAPPNCRP 9835
            | |..:.:|...|.|..:..:            |    |||.......| .|.||.:.. |:|:|
  Fly   539 SYCDCDNQGTESEICNKQSGQ------------C----ICREGFGGPRCDQCLPGFYNY-PDCKP 586

  Fly  9836 ECVINQDCPSNRACIRQRCEDPCIGICGFNAVCSTQNHQPKCSCIESFEGDPYTACKMREIVVLD 9900
             |    :|.|.                |.:|:  |.::..||:|:.:|.|...|.|.......
  Fly   587 -C----NCSST----------------GSSAI--TCDNTGKCNCLNNFAGKQCTLCTAGYYSY-- 626

  Fly  9901 PPTDPCYPSPCGANAI-CRVRNGAGSCSCIQNYFGDPYINCR------PECVQNSDCPNNRACIN 9958
            |...||:....|:..: |   |..|.|.|..|:.|....:|:      |.|   .||
  Fly   627 PDCLPCHCDSHGSQGVSC---NSDGQCLCQPNFDGRQCDSCKEGFYNFPSC---EDC-------- 677

  Fly  9959 MKCRDPCANACGFNAICRVAHHQPVCSCEPHLTGNPLRACVERPSNMYLPLPKDPCRPSPCGLFS 10023
             .| ||......| |.|.......:|.|:..:||   |.|.|             |:|    |:.
  Fly   678 -NC-DPAGVIDKF-AGCGSVPVGELCKCKERVTG---RICNE-------------CKP----LYW 719

  Fly 10024 TCHVVGER--PVCACLPD-YMGAPPNCKPECMTSAECP-----SDRACINQRCKD---------- 10070
            ..::....  .:|.|..| .:.|...|..:   |.:||     ..|.|  |.|:|
  Fly   720 NLNISNTEGCEICDCWTDGTISALDTCTSK---SGQCPCKPHTQGRRC--QECRDGTFDLDSASL 779

  Fly 10071 ----PCPGTCGYNARCRCTNHSPICSCYDGYTG------------DPFHQCVPERKPPPIADPIV 10119
                .|....|.:.:..|...|..|.|:...||            ...||...|.:     |..:
  Fly   780 FGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYE-----DGSL 839

  Fly 10120 PPNPCVPSPCGPNSQCQVSSSG-AVCSCVTNYIGRPPGCRPECSINSECPARMAC----INARCA 10179
            |....|.......:....||.| .|.:.:.|.:      |.|.::......|:..    .||...
  Fly   840 PSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDV------RNEVNVFKSSLYRIVLRYVNPNAENV 898

  Fly 10180 DPCIGSCGNNALCHVSLHAPVCM---CEPGY---SG-----------DPFSGCY-------KIIE 10220
            ...|....:|.| .|..|..|.:   .||.:   :|           ||  |.|       |.:.
  Fly   899 TATISVTSDNPL-EVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDP--GRYVFTTKANKNVM 960

  Fly 10221 TPIEVIQPCR-----------PSPCGLN--ALCEERNQAAACKCLPEYF---GDPYVECRPECVI 10269
            ....|:.|..           .:||.|.  .||.....|:.     |.|   ..|:       ||
  Fly   961 LDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASV-----EVFSPAATPF-------VI 1013

  Fly 10270 NSDCPRSRACVNQKCVDPCPGMCGHNALCAVFNHAPNCECLPGYTGNPIVGCHIVPESPRY---- 10330
            ..         |.|..:|.........| .:.:|..:...|.| :.|.:.....||.|.||
  Fly  1014 GE---------NSKPTNPVETYTDPEHL-QIVSHVGDIPVLSG-SQNELHYIVDVPRSGRYIFVI 1067

  Fly 10331 --------PDPI-----VPENPCQPS-----PCGLYSN-CR-PVNGHAVCSCVPSYIGSPPNCRP 10375
                    ||..     :.:||...:     || |||. || .||...:   ..|:..:..:.:|
  Fly  1068 DYISDRNFPDSYYINLKLKDNPDSETSVLLYPC-LYSTICRTSVNEDGM---EKSFYINKEDLQP 1128

  Fly 10376 ECMSSSECAQDKSCLNERCKDPCPGTCG---NNALCRVVNHNPICSCSPGFSGDPFVRCFPQEKR 10437
            ..:|:.        :.:..:.|......   :......:|.:|:|.........|..|..|..|:
  Fly  1129 VIISAD--------IEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKK 1185

  Fly 10438 PPITHDRIDPCVPS--PCGPNSE----CRVSAANEQAVCSCLQHYVGRAPNCRPECTSDSECPGN 10496
            .....|..|....:  |.....|    ..:.:.||..:..              |...|:..| |
  Fly  1186 IEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVI--------------ESKVDATKP-N 1235

  Fly 10497 LACINLRCRDPCVGTCGIQTTCLVNNHRPICRCIDGYAGDPFSECSPKINVPVQVAQPCNPSPCG 10561
            |..|.::...|......:..|.....::        |.|        |.::     |.| ||..|
  Fly  1236 LFVILVKYYQPSHPKYQVYYTLTAGKNQ--------YDG--------KFDI-----QHC-PSSSG 1278

  Fly 10562 ANAVCKERNGVGSCSC-------------------------LPEYNGDPYTECRPECVLNSDCSK 10601
            ...|.:.. |.||...                         |.:||.|        .::.....:
  Fly  1279 CRGVIRPA-GEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDD--------LLVEETFDQ 1334

  Fly 10602 NRACLNNKCRDPCPGVCGVSAECHVINHAPSCSCPSGFTGNPSQFCRE-IPRLPAPVE----PCR 10661
            .:..:.|         ||     |...|         .|.|.|.||:: :..|.|...    ||.
  Fly  1335 TKEFIQN---------CG-----HDHFH---------ITHNASDFCKKSVFSLTADYNSGALPCN 1376

  Fly 10662 PSPCGPYS-QCREVNGHAVCSCVTNYI-GTPPACR------PECSVSSECAQDRACVNQRCADPC 10718
            ....|..| :|....|.  |.|..|.| .|..|||      |:|.                  ||
  Fly  1377 CDYAGSTSFECHPFGGQ--CQCKPNVIERTCGACRSRYYGFPDCK------------------PC 1421

  Fly 10719 PGTCGNEAICKVTNHNPICSCPAGYSGDPFVRCAPWQEEPEQPKSNENPCVPSPCG---RNSQCR 10780
              .|.|.|:|:.|...  |.||....||...:|||......|....|. |..:|.|   .||||.
  Fly  1422 --KCPNSAMCEPTTGE--CMCPPNVIGDLCEKCAPNTYGFHQVIGCEE-CACNPMGIANGNSQCD 1481

  Fly 10781 VVGETGVCSCLPNFVGRAPNCRPECTINTECPANLACINERCQDPCPGSCGFNAFCSVVNHSPIC 10845
            :.  .|.|.|..|..|||                                     |.|
  Fly  1482 LF--NGTCECRQNIEGRA-------------------------------------CDV------- 1500

  Fly 10846 TCDSGYTGDPFAGCNPQPPAIPDERLTPCQPSPC-GPNAE---CRERNGAGSCTCLPEYFGDPYS 10906
             |.:||...|.                 |:...| .|..|   |.:.:||  |.|
  Fly  1501 -CSNGYFNFPH-----------------CEQCSCHKPGTELEVCDKIDGA--CFC---------- 1535

  Fly 10907 GCRPECVVNSDCSRDKSCVNQKCVDPCPGVCGLNAQCRVSNHLPSCSCLAGYTGNPSSACREI-- 10969
               .:.||..||        .:|||..     .|.|....:...:|.|. |.|....||...:
  Fly  1536 ---KKNVVGRDC--------DQCVDGT-----YNLQESNPDGCTTCFCF-GKTSRCDSAYLRVYN 1583

  Fly 10970 -----------PQL----------PPPPE---------------RDENPCRPSPCGPYSQCREVD 10998
                       |:.          |.|.:               |:.|..||:..|........:
  Fly  1584 VSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQN 1648

  Fly 10999 GHA---------VCSCLQGFIGSAPNCRPECIISSD--CAQNLNCQNQKCVDPCPGTCGI-EARC 11051
            .|.         ......||.|.. ...|:.|:.|:  ...:.:.:.....:|......| |:..
  Fly  1649 NHISAYGGDLAYTLHFTSGFDGKY-IVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNF 1712

  Fly 11052 QVINHYPA-------------------------------------------------------CS 11061
            |.|:..|.                                                       ||
  Fly  1713 QTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCS 1777

  Fly 11062 CAPGFTGDPFNRCTKILLEP----PPTEKSGNPCIPSPCGPNSKCLDVRGSPACS---------- 11112
            |.||::|.....|.     |    .|:...|..|||..|..:|:..|. .:..||
  Fly  1778 CPPGYSGHSCEDCA-----PGYYRDPSGPYGGYCIPCECNGHSETCDC-ATGICSKCQHGTEGDH 1836

  Fly 11113 ---CLPDYLGRPPNCRP-ECLSSADCPANLACVNQRCSNPCIGACGLHSVCTVIKHRPACECVPG 11173
               |:..|.|...|..| :|:..| ||....      ||....:|.:......|.    |||.||
  Fly  1837 CERCVSGYYGNATNGTPGDCMICA-CPLPFD------SNNFATSCEISESGDQIH----CECKPG 1890

  Fly 11174 YTGDPFSGCAIVQQIAPPDETRNPCNPSPCGANAICRERNGAGSCACLPEYFGDPYS---GCRP- 11234
            |||.....||                             ||         ::|:|.|   .|:|
  Fly  1891 YTGPRCESCA-----------------------------NG---------FYGEPESIGQVCKPC 1917

  Fly 11235 ECVQNDDCDRSRACINNKCQDPCPGACGINAEC-RVLNH--GPNCN-CFDGYTGDPHR-----SC 11290
            ||..|         ||.:.|..|....|   || |.||:  |..|| |..|:.||..:     ||
  Fly  1918 ECSGN---------INPEDQGSCDTRTG---ECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSC 1970

  Fly 11291 SLIEVVTIRPEPCKPSPCGPYSQCLDTNSHAVCSCLEGYIG-APPSCKPECVVSSECPQNRACIN 11354
            ...::.|        ..|.|:.        .||:|.|..|| ....|||:..........|||
  Fly  1971 DCDDLGT--------QTCDPFV--------GVCTCHENVIGDRCDRCKPDHYGFESGVGCRAC-- 2017

  Fly 11355 QKCEDPCRGSCGNNAKCQVVNHNPICTCQPGMTGDPISGCEPMPEVKNVENPCVPSPCGPNSVCR 11419
                 .| |:..|:.:|.  .|...|.|:.|:||.....| .:...|..::.|.|
  Fly  2018 -----DC-GAASNSTQCD--PHTGHCACKSGVTGRQCDRC-AVDHWKYEKDGCTP---------- 2063

  Fly 11420 QIGNQAACSCNAGYIGRPPTCRPECTNNDECQNHLSCQQERCVDPCPG--------SCGSNAICQ 11476
                   |:||.|| .|...|.|   |..:||.......:|| |.||.        .|.....|
  Fly  2064 -------CNCNQGY-SRGFGCNP---NTGKCQCLPGVIGDRC-DACPNRWVLIKDEGCQECNNC- 2115

  Fly 11477 VVQHNAVCSCAD 11488
               |:|:....|
  Fly  2116 ---HHALLDVTD 2124

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.