DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Best3

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001007584.1	Gene:	Best3 / 382427	MGIID:	3580298	Length:	669	Species:	Mus musculus

Alignment Length:	399	Identity:	94/399 - (23%)
Similarity:	143/399 - (35%)	Gaps:	96/399 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  6447 IRVEE--STLPSRSTDRTSPSESPETPTTL-PSDFITRPHSEKTTESTRDVPTTRPFEASTPSSA 6508
            :.|:|  .:||....|......:...|.|| .:|:.              :|:   |..||....
Mouse   320 LAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYC--------------IPS---FLGSTIQMG 367

  Fly  6509 SSGNNC-SISYFRNHYKCSNRFN--RSADR-TTPSESPETPTLPSDFTTRPHSEQTTESTRDVPT 6569
            .||:|. :..:..|:.|..||.:  |...| .:..|.|.:|.     ..|....|.::|:..:|
Mouse   368 LSGSNFPAEDWLWNYEKHGNRHSVMRRVKRFLSTHEHPGSPR-----RRRSFGRQASDSSMFLP- 426

  Fly  6570 TRPFEASTPSPASLETTVPSVTSETTTNVPIGS-TGGQVTGQTTAPP--------SEVRTTIRVE 6625
                    ||||.....|||      .|...|| |..|...|..:|.        |.:|.|.|.
Mouse   427 --------PSPARDLLDVPS------RNPHRGSPTRKQSRSQEGSPKLHSSMGELSTIRETSRT- 476

  Fly  6626 ESTLPS---RSTDRTTPSESPETPTIL------PSDFTTRPHSDQTTESTRDVPTTRPFEASTPR 6681
             |||.|   :|:.|::|::.|:.|.:|      |: |:...|...:|.|...:..|....:.|.:
Mouse   477 -STLQSLSPQSSVRSSPTKMPQVPEVLITAAEAPA-FSADSHQHDSTTSILSLEFTGVQPSGTEQ 539

  Fly  6682 PVTLETAVPSVTLETTTNVPIGSTGGQVTGQTTATPSEVRTTIRVEESTLPSRSTDRTTPSESPE 6746
            .|.                |.|:..|....|||:..:| |...:.||.....|...|.:..|..|
Mouse   540 QVE----------------PSGTPPGDPNPQTTSASTE-RDLFKFEEDLEDDRFPKRWSLPEFLE 587

  Fly  6747 TPTTLPSDFTTRPHSDQ------TTESTRDVPTTRPFEASTPSPASL--------ETTVPSVTSE 6797
            :..|...:....|.|.:      .||:..:.....|...|..:|..|        ||.:....:|
Mouse   588 SRHTSLGNLGPDPVSPRDALLLPDTETPSETNGIHPGAGSALAPDILYLMESLDKETDILEFNNE 652

  Fly  6798 TTTNVPIGS 6806
            .|...|.|:
Mouse   653 HTGESPKGT 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	94/399 (24%)
		DUF4758	6662..6839	CDD:292572	34/159 (21%)
		DUF4758	6764..6941	CDD:292572	12/51 (24%)
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Best3	NP_001007584.1	Bestrophin	8..315	CDD:279411
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..496		32/118 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..560		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..627		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..669		4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910