DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and p130CAS

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	860	Identity:	168/860 - (19%)
Similarity:	270/860 - (31%)	Gaps:	291/860 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  4434 EVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPS 4498
            |.::..||.|:::.:.:...|.|..  :|.:.|..      |.::..:..:..|
  Fly     2 ECQSENRVPENSISNVATYHTLPES--QTSSVLAK------HQQRQLKEPQQPP----------- 47

  Fly  4499 SASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTLSESPE 4563
                :..:.||.:...|......|||.:        ...::..::....:....||     .|.|
  Fly    48 ----QYVINSVAMHAKTTTANSITGGTL--------HRAKSAQKLYAKAIYDNYAD-----TSDE 95

  Fly  4564 TPTTLPSDFTIRPHSEQTTE--------STRD----VPTTR-----PFEAS--TPSPASLETTVP 4609
            .|.......|:   .||.||        |.|:    .|..|     .:::.  :|||||  :.||
  Fly    96 LPFKKGDILTV---LEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLNSYDSGCFSPSPAS--SPVP 155

  Fly  4610 SVTSETTT-NVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPSESPETPT--ILP 4671
            |:.:.|.| :..|.|......|...:..|...:......|.|.|.|..|.:......:||  |.|
  Fly   156 SLAASTATLDSSICSAEIYENGSVISAVSSSNSNSGGASSGLGSESVSRVSRRSWHASPTKVITP 220

  Fly  4672 ---SDSTTRTYS--DQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVT 4731
               .|.....||  ..|....|..|       |||..            :..:|..|......:
  Fly   221 QRHGDVYIYNYSPGSATGSGARAAP-------STPQQ------------QIYSNQSIYQNFAMM- 265

  Fly  4732 EQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHS--EKTTESTRDVPT 4794
                |||.:..:....|...:|           .|.||..|..|   .|.|  .|.:.||
  Fly   266 ----SSPRQNASGSEFETYDIP-----------KPATPVPLNYD---SPRSGLPKASNST----- 307

  Fly  4795 TRPFEASTPSSASLET---TVPSVT---LETTTNVP----IGSTGGQVTEQTTS-SPSEVRTTIR 4848
                   |.||:||.|   |:.||.   .|.:.:||    :||  .|:.:|.:. :||...:::.
  Fly   308 -------TTSSSSLGTRFETLKSVAASIAEESYDVPRPLILGS--NQLQQQMSQMTPSSSASSLL 363

  Fly  4849 VEES-TLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSA---- 4908
            ..:| :|...|::|::.:..|:                      .|:|...|.......|.
  Fly   364 TSDSLSLSFSSSNRSSLANMPD----------------------YDIPRRNPLPVRRQQSGLTYD 406

  Fly  4909 ----SLETTVPSV-----TLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRT 4964
                .|:..||.|     |:.||..:|:          ..||..|....::::.:...:|.....
  Fly   407 FPLPPLQEQVPRVLCTPSTVTTTKELPL----------ELSSALETLAKLQLQTTAAINRLLSFV 461

  Fly  4965 TPSESPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETT----T 5025
            .|            ::.||...|                     ||.::..:.::.|.||    .
  Fly   462 VP------------NWRTRAQLE---------------------PAIMDLKLAALRLRTTLHDLA 493

  Fly  5026 NVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRT--TPSESPETPTTLPSDFITRTYS 5088
            ....|:.|.....:..:...::|..:|.      .|.|::.  ..|||.:.......|.:.|  |
  Fly   494 EFGEGALGNATRSEDRNLALKLRPLVRA------LRDANKLIHDSSESLDAQGAWSIDQLAR--S 550

  Fly  5089 DQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETT-----------TNVPIGSTGGQVTG-- 5140
            |:.       ...||.:|........:|....|.|.|:           ..:.:|..||..||
  Fly   551 DEK-------HGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQLTVGHNGGSGTGVL 608

  Fly  5141 -------------------------------QTTAP---PSEFRTTIRVEES-----------TL 5160
                                           :...|   .::|.|.||..||           |.
  Fly   609 EGSRGSAEWLEDYDYVAFESKDAAARKNEALREAIPADLKTQFDTVIRTAESSAMGAGSGSIPTT 673

  Fly  5161 PSRSTDRTTPSESPE 5175
            |:..|..|||.:|||
  Fly   674 PTARTTPTTPCKSPE 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	54/268 (20%)
		DUF4758	4275..4448	CDD:292572	4/13 (31%)
		DUF4758	4377..4574	CDD:292572	21/139 (15%)
		DUF4758	4581..4754	CDD:292572	44/199 (22%)
		DUF4758	4683..4847	CDD:292572	41/176 (23%)
		DUF4758	4785..4964	CDD:292572	41/203 (20%)
		DUF4696	4841..5385	CDD:292395	72/413 (17%)
		DUF4758	4887..5098	CDD:292572	38/229 (17%)
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	14/62 (23%)
		Serine_rich_CAS	434..596	CDD:211403	33/219 (15%)
		DUF3513	612..817	CDD:288849	16/77 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910