DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and AGRN

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001292204.1 Gene:AGRN / 375790 HGNCID:329 Length:2068 Species:Homo sapiens


Alignment Length:2365 Identity:464/2365 - (19%)
Similarity:620/2365 - (26%) Gaps:1099/2365 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly  9998 CVE-RPSNMYLPLPKDP---CRPSPCGLFSTCHVVGERPVCACLPDYMGAPPNCKPECMTSAECP 10058
            ||| :|...:.|:|..|   ||...||..:.|.                  ||        ||.|
Human   152 CVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCE------------------PN--------AEGP 190

  Fly 10059 SDRACINQRC-KDPCPG----TCGYNARCRCTNHSPICSCYDGYTGDPFHQCVPERKPPPIADPI 10118
            ...:|:   | |.|||.    .||.:|    :.:|..|.....       ||..:|:...::   
Human   191 GRASCV---CKKSPCPSVVAPVCGSDA----STYSNECELQRA-------QCSQQRRIRLLS--- 238

  Fly 10119 VPPNPCVPSPCGPNSQCQVSSSGAVCSCVTNYIGRPPGCRPECSINSECPARMACINARCADPCI 10183
                   ..|||         |...||.||            ||..|.|        ||.||...
Human   239 -------RGPCG---------SRDPCSNVT------------CSFGSTC--------ARSADGLT 267

  Fly 10184 GSCGNNALCHVSLHAPVCMCEPGYSGDPFSGCYKIIETPIEVIQPCRPSPCGLNALCEERNQAAA 10248
            .||...|.|..:....||    |..|..:.|                                  
Human   268 ASCLCPATCRGAPEGTVC----GSDGADYPG---------------------------------- 294

  Fly 10249 CKCLPEYFGDPYVECRPECVINSDCPRSRACVNQKCV--------DPCPGMCGHNALCAVFNHAP 10305
                             ||.:     ..|||..|:.|        |||.|               
Human   295 -----------------ECQL-----LRRACARQENVFKKFDGPCDPCQG--------------- 322

  Fly 10306 NCECLPGYTGNPIVGCHIVPESPRYPDPIV-PEN-PCQPSP-CG----LYSNCRPVNGHAVCSCV 10363
               .||    :|...|.:.|.: |.|:.:: ||: |.:.:| ||    .|.|          .||
Human   323 ---ALP----DPSRSCRVNPRT-RRPEMLLRPESCPARQAPVCGDDGVTYEN----------DCV 369

  Fly 10364 PSYIGSPPNCRPECMSSSECAQDKSCLNERCKDPCPGTCGNNALCRVVNHNPICSCSPGFSGDPF 10428
            ....|:......:.:.|.:|         :.:|.||..|..||:|......|.|||         
Human   370 MGRSGAARGLLLQKVRSGQC---------QGRDQCPEPCRFNAVCLSRRGRPRCSC--------- 416

  Fly 10429 VRCFPQEKRPPITHDRIDPCVPSPCGPNSECRVSAANEQAVCSCLQHYVGRAPNCRPEC-----T 10488
                          ||:                         :|...|       ||.|     |
Human   417 --------------DRV-------------------------TCDGAY-------RPVCAQDGRT 435

  Fly 10489 SDSECPGNLACINLRCRDPCVGTCGIQTTCLVNNHRPICRCIDGYAGDPFSECSPKINVPVQVAQ 10553
            .||:|....|    .||         |...:.:.|:..|.                     |...
Human   436 YDSDCWRQQA----ECR---------QQRAIPSKHQGPCD---------------------QAPS 466

  Fly 10554 PCNPSPCGANAVCKERNGVGSCSCLPEYNGDPYTECRPECVLNSDCSKNRACLNNKCRDPCPGVC 10618
            ||....|...|.|..:||..:|.||                        :||  :...||   ||
Human   467 PCLGVQCAFGATCAVKNGQAACECL------------------------QAC--SSLYDP---VC 502

  Fly 10619 GVSAECHVINHAPSC-----SCPSGFTGNPSQFCREIPRLPAPVEPCRPSPCGPYSQCREVNGHA 10678
            |...    :.:..:|     :|..|         |||       :..|..||....|||   ..|
Human   503 GSDG----VTYGSACELEATACTLG---------REI-------QVARKGPCDRCGQCR---FGA 544

  Fly 10679 VCSCVTNYIGTPPAC----RPEC-----SVSSEC-AQDRACVNQ-----RCADPCPGTCGNEAIC 10728
            :|...|.....|..|    :|.|     :..||| ....||.:|     ..|.||. ||| :|:|
Human   545 LCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCE-TCG-DAVC 607

  Fly 10729 KVTNHNPICSCPAGYSGDPFVRCAPWQEEPEQPKSNENPCVPSPCGRNSQCRVVGETGVCSCLPN 10793
            .   ...:||                                              .|.|.|   
Human   608 A---FGAVCS----------------------------------------------AGQCVC--- 620

  Fly 10794 FVGRAPNCRPECTINTECPANLACINERCQDPCPGSCGFNAFCSVVNHSPICTCDSGYTGDPF-- 10856
                                      .||:.|.||              |:|..|....|...  
Human   621 --------------------------PRCEHPPPG--------------PVCGSDGVTYGSACEL 645

  Fly 10857 --AGCNPQPPAIPDERLTPCQPSPCGPNAE------------CRERNGA-------GSCTCLPEY 10900
              |.| .|...|.:.|..||:.:.||....            ||:|.|.       |.|.|    
Human   646 REAAC-LQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVC---- 705

  Fly 10901 FGDPYSGCRPECVVNSDCSRDKSCVNQKCVDPCPG--VCG-----LNAQCRVSNHLPSCSCLAGY 10958
                                |.||      ...||  |||     .:.:|.:..  ..|....|.
Human   706 --------------------DFSC------QSVPGSPVCGSDGVTYSTECELKK--ARCESQRGL 742

  Fly 10959 TGNPSSACREIPQLPPPPERDENPCRPSPCG--PYSQCRE----VDGHAVCSCLQGFIGSAPNCR 11017
            ......|||. |...|.|     |..|..|.  ||..|::    ..|..:..|     .||..|.
Human   743 YVAAQGACRG-PTFAPLP-----PVAPLHCAQTPYGCCQDNITAARGVGLAGC-----PSACQCN 796

  Fly 11018 PECIISSDCAQNLNCQNQKCVDPCPGTCGIEARCQVINHYPACSCAPGFTGDPFNRCTKILLEP- 11081
            |.......|            ||..|               .|||.||..|...:||     || 
Human   797 PHGSYGGTC------------DPATG---------------QCSCRPGVGGLRCDRC-----EPG 829

  Fly 11082 -------PPTEKSGNPCIPSPCGP----NSKCLDVRGSPACSCLPDYLGRPPNCRPECLSSADCP 11135
                   ....:||  |.|..|.|    ...|..:.|  .|||.|...|      |:|   ..||
Human   830 FWNFRGIVTDGRSG--CTPCSCDPQGAVRDDCEQMTG--LCSCKPGVAG------PKC---GQCP 881

  Fly 11136 ANLACVNQRCSNPCIGACGLHSVCTVIKHRPACECVPGYTGDPFSGCAIVQQIAPPDETRNPCNP 11200
            ...|          :|..|    |......||                             .|..
Human   882 DGRA----------LGPAG----CEADASAPA-----------------------------TCAE 903

  Fly 11201 SPCGANAICRERNGAGSCACLPEYFGDPYSGCRPECVQNDDCDRSRACINNKCQDPCPGACGINA 11265
            ..|...|.|.|.:|:..|.|       |...| ||......|........|:||.... ||....
Human   904 MRCEFGARCVEESGSAHCVC-------PMLTC-PEANATKVCGSDGVTYGNECQLKTI-ACRQGL 959

  Fly 11266 ECRVLNHGPNCNCFDGYTGDPHRSCSLIEVVT--IRPEPCKPSPCGPYSQCLDTNSHAVCSCLEG 11328
            :..:.:.||   |.:......|.:.:.:.|.|  :......|:|.|.......:.:|:..:    
Human   960 QISIQSLGP---CQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTT---- 1017

  Fly 11329 YIGAPPSCKPECVVSSECPQNRACINQKCEDPCRGSCGNNAKCQVVNHNPICTCQPGMTGDPISG 11393
               .|||.:|....|.                                 |..|..|.:|      
Human  1018 ---PPPSSRPRTTASV---------------------------------PRTTVWPVLT------ 1040

  Fly 11394 CEPMPEVKNVENPCVPSPCGPNSVCRQIGNQAACSCNAGYIGRPPTCRPECTNNDECQNHLSCQQ 11458
               :|       |..||| .|:.|....|...:..                .::||   .||..|
Human  1041 ---VP-------PTAPSP-APSLVASAFGESGSTD----------------GSSDE---ELSGDQ 1075

  Fly 11459 ERCVDPCPGSCGSNAICQVVQHNAVCSCADGYEGEPLFGCQLIPAVTPTESPSSPCEPSPCGPHA 11523
            |      ....||..:                  |||.|             ||...|.|....|
Human  1076 E------ASGGGSGGL------------------EPLEG-------------SSVATPGPPVERA 1103

  Fly 11524 ECRERNGAGACYCHDGFEGNPYDAQRGCRRECENNDDCTA------------VQACSRF---KCV 11573
            .|  .|.|..| |.|| :....||:         ..:|.|            |:....|   :..
Human  1104 SC--YNSALGC-CSDG-KTPSLDAE---------GSNCPATKVFQGVLELEGVEGQELFYTPEMA 1155

  Fly 11574 DPCNNICGDYAICTVDKHVPTCDCPPGYTGDPFFSCKPVPVTPRPPLNPCNPSPCGPNSNCRAMN 11638
            ||.:.:.|:.|     :.:.:       |.|..|....|    :...........||..:.||:.
Human  1156 DPKSELFGETA-----RSIES-------TLDDLFRNSDV----KKDFRSVRLRDLGPGKSVRAIV 1204

  Fly 11639 NQAVCSCQAGFINQPPNCKPECVVSAECAPEKA-CVHKKCVDPCQHTCGIRAICTTKNHSPICTC 11702
            :          ::..|       .:|..||:.| .:.::.....:.:.|:|        .|:...
Human  1205 D----------VHFDP-------TTAFRAPDVARALLRQIQVSRRRSLGVR--------RPLQEH 1244

  Fly 11703 PRTMTGDPF----VECTRVAI----TNDNTTPSPAPASCV-PSPCGPNAKCQIVGNSPACSCLPN 11758
            .|.|..|.|    ...|..||    |...||.|..|:|.| |....|:...|.|..:.|      
Human  1245 VRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTA------ 1303

  Fly 11759 FIGAPPRCRPECVLNSECGPTEACINQKCADPCSGSCGFEAKCHVLNHLPICNCIEGYEGDPFVR 11823
               ||...||         ||.|                                          
Human  1304 ---APTTRRP---------PTTA------------------------------------------ 1314

  Fly 11824 CTKKEEDRSPPPPNDPCNPNPCGQNADCFAGECRCQNNYQGNAYEGCRPECTLSADCPRDKACMR 11888
             ..:...|.||.|..|  |.|| .:..||.|. .||:...|..:         :..||..:    
Human  1315 -PSRVPGRRPPAPQQP--PKPC-DSQPCFHGG-TCQDWALGGGF---------TCSCPAGR---- 1361

  Fly 11889 NRCVDPCPGICGNNAVCEVMNHIPVCSCVKGYEGDPFV--------------------------- 11926
                        ..||||.:...|    |..:||..|:                           
Human  1362 ------------GGAVCEKVLGAP----VPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLL 1410

  Fly 11927 ---NCRVK---------------------PVV------------------------------EDP 11937
               |.|.|                     |.|                              |.|
Human  1411 YNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETP 1475

  Fly 11938 IIEACSPSPCGSNSQCRDVNGHAVCSCLEGYIGAPPQCRPECVVSSE----CSALQACVNKKCVD 11998
            ::   ..||.|::....|.         :.::|..|:  .:..|:.|    .:.|:.|:.     
Human  1476 VL---GESPSGTDGLNLDT---------DLFVGGVPE--DQAAVALERTFVGAGLRGCIR----- 1521

  Fly 11999 PCAAACGLEARCEVINHSPICGCPPGRT--GDPFKQCVVLPPIAVPDVKSPPQDPCVPSPCGPNS 12061
                      ..:|.|.....|..||..  |....:|              ...||:|:||...:
Human  1522 ----------LLDVNNQRLELGIGPGAATRGSGVGEC--------------GDHPCLPNPCHGGA 1562

  Fly 12062 ICKNDRNGPV-CQCQPEFFGSPPNCRPECIINPDCQSTQACINNKCSNPC-PESCGTNAECRVIG 12124
            .|:|...|.. |||.|...|  |.|..|                  .:|| |..|...|.|||:.
Human  1563 PCQNLEAGRFHCQCPPGRVG--PTCADE------------------KSPCQPNPCHGAAPCRVLP 1607

  Fly 12125 H-AVSCSCPTGYAGNAFVQCVPQQE 12148
            . ...|.||.|..| .|.|....|:
Human  1608 EGGAQCECPLGREG-TFCQTASGQD 1631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
AGRNNP_001292204.1 NtA 44..146 CDD:308653
KAZAL 196..242 CDD:197624 13/69 (19%)
KAZAL 272..317 CDD:197624 14/104 (13%)
KAZAL_FS 349..389 CDD:320757 10/49 (20%)
KAZAL_FS 421..461 CDD:238052 14/59 (24%)
KAZAL 489..534 CDD:197624 16/93 (17%)
KAZAL 554..599 CDD:197624 11/44 (25%)
KAZAL 619..664 CDD:197624 15/88 (17%)
KAZAL 704..750 CDD:197624 12/77 (16%)
Laminin_EGF 793..835 CDD:278482 16/73 (22%)
Laminin_EGF 847..>883 CDD:278482 13/46 (28%)
KAZAL 922..969 CDD:197624 13/58 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 995..1096 35/213 (16%)
SEA 1130..1254 CDD:214554 26/164 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1334 24/120 (20%)
EGF 1333..1363 CDD:306513 9/56 (16%)
Laminin_G_1 1400..1531 CDD:278483 19/159 (12%)
EGF_CA 1555..1585 CDD:238011 12/31 (39%)
Laminin_G_1 1668..1803 CDD:278483
EGF_CA 1825..1857 CDD:238011
Laminin_G_1 1921..2051 CDD:278483
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.