DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and CG18368

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_610896.1	Gene:	CG18368 / 36519	FlyBaseID:	FBgn0033864	Length:	1154	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	120/678 - (17%)
Similarity:	199/678 - (29%)	Gaps:	263/678 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  2906 CLQPQACGQNAE------CVMQNHLKQC-HCPEGFTGDSAKECV--------------RVPVACD 2949
            |:.||....:||      .|..|.:..| |...|...:|..:.:              :..:.||
  Fly   369 CIDPQVPSSSAEQKVDSKRVNGNIMDSCSHNLGGQKNESGPKMIPPYDQKLTGFYDTLKNRILCD 433

  Fly  2950 GECGPGYTCRDSMCLPVCHNDLECASNEKCLKG--------SCM----------------LTCRV 2990
            .. .....|:.::..|   |..:|.|...|...        ||.                |.|..
  Fly   434 NS-SEKKDCKAALKPP---NTADCISKIPCSNAANVDNQPPSCQSGNSLHKVFKSRVHKNLWCSP 494

  Fly  2991 DNDCFLGHV-------------CLHNK-------------CVY--GCHVDDDCSASESC---RND 3024
            :||...|.:             .|.:|             |::  ...:..|...::.|   ..|
  Fly   495 ENDIDKGGIKSKKDIDFSKFFSMLDDKDKLKFRVAELMVRCMFLMEKRMQQDLKGNKVCNVEEKD 559

  Fly  3025 KCVNPCLEN---------PCGPNAACSVSNHRASCSCLESMVPNPTPQVGCVRSPPL---ECREN 3077
            ..||..:||         .|....||::||        .||:.| |...|.:....:   :|...
  Fly   560 NNVNQLVENFWRHYIQCCECQKKDACALSN--------PSMLGN-TEYTGILNKVDVIIKQCTHI 615

  Fly  3078 RDCGNGLACFESVCRPLCADDAGCLTNERCQQGVCKPLCR--------------------HDNEC 3122
            ::...|.:                |.|:..:.|:.:.:..                    ..||.
  Fly   616 KEVIEGRS----------------LKNQCIKHGLSQSIAEEFYKAMAKLEKMSANEKLKTESNEF 664

  Fly  3123 GHGELCLGLNCVPGCRSDQGCPPELSCVGQQCVDPCADPTACGTNAHCQTIDHRKQCLCPEG--- 3184
            |     |..||......|: |..:...|         :......:..|:|.|..:|.|..:.
  Fly   665 G-----LNRNCAIESLKDK-CQEKKDFV---------EDVLKNMSLECKTSDKYEQDLLSKMKLV 714

  Fly  3185 -LDGNANVACKVPRIACGRNEDCQSNQLCYAGSCQGKCRNDQNCLADERCMRGTCRTVCNTDEAC 3248
             .:....:|.:...|...:.:|..|.: |.....:.||..::   ..|:|      .:....|.|
  Fly   715 IKELQKKLAEEKENIISTKQKDLFSEK-CAEEELKSKCAKEE---LKEKC------AIEELKEKC 769

  Fly  3249 AQGQICENRMCQTGCRTDL--SCATDEACVNKKCQNPCRTPGQCGQCADCLVVNHGVQCQCPAAF 3311
            |:.::  .:||..   .||  .||.:|  :.|||
  Fly   770 AEEEL--RKMCAI---EDLKEKCAEEE--LKKKC------------------------------- 796

  Fly  3312 MGDGLTGCQLPPERCHPDCECDENGAYCAPKCSRTE-DCACGQQ-----CARGKCRNKCGP---K 3367
                                ..||   ...||:|.| ..||.::     ||..:.:.||..   |
  Fly   797 --------------------AKEN---LKEKCARKELKKACAEEEFRRKCAENELKEKCAEQELK 838

  Fly  3368 RQCTVGQLCERGACIAGCKSNGDCAAD---QSCVNGKCSDPCANEKACGRNALCTVSEHRMLCYC 3429
            .:|.:.:..|.            ||.:   |.|......|.|::|....|::|   :|.:..|
  Fly   839 EKCALKEFREL------------CANEELKQKCAEKDFKDKCSDENLKERSSL---NEQQRQC-- 886

  Fly  3430 PDGYEGEPSKECVQFECRVDTDCDSNKR 3457
               .|....|.|.:|..::  .|::|.|
  Fly   887 ---EEFSWRKRCAEFALKM--KCENNNR 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CG18368	NP_610896.1	TolA	702..>866	CDD:225606	43/246 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910