DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Nup54

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_610783.1	Gene:	Nup54 / 36360	FlyBaseID:	FBgn0033737	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	632	Identity:	118/632 - (18%)
Similarity:	179/632 - (28%)	Gaps:	233/632 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  7616 TNVPIGSTG---GQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRP 7677
            |:.|..:||   |...|.|.|| |:.....|.:.::.|:....
  Fly    13 TSTPAKTTGGLFGSPFGGTAAT-SQPAPAFGAQATSTPAFGAQ---------------------- 54

  Fly  7678 HSDQTTESTRDVPTTRPFEASTPRPVTLETAVPSVTSETTTNV----PIGSTVT--SETTTNVPI 7736
                        |.|..|.|.:....|  .|.|:..:.|.|:.    ..|||..  :.|||....
  Fly    55 ------------PATSAFGAGSAFGAT--AAAPAFGAATGTSAFGGSAFGSTPAFGAATTTTAGT 105

  Fly  7737 GSTGGQVAGQTTAPPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFTTRPHSEQTTES 7801
            |..||...|...||.:              |::.....|:.|...|..  |.|     .:|...|
  Fly   106 GLGGGGFGGFGAAPAT--------------SQAGLFGAPATSAAPPAF--SGF-----GQQAAAS 149

  Fly  7802 TRDVPTTRPFEASTPSPASLETTVPSV----TSE------------------TTTNVPIGSTGGQ 7844
            |........|..:|       |:.|:.    ||:                  ||.....|..||
  Fly   150 TAPASGFSGFGTTT-------TSAPAFGGFGTSQSTGFGGGAFGSTFGKPANTTVTPGFGGFGG- 206

  Fly  7845 LTEQSTSSPSEVRTTIRVEESTLPS------------------------RSTDRTFPSESPEKPT 7885
             |......|.:....|..:|:...|                        ..|.:.|.|:|
  Fly   207 -TSFMLGQPQQQPAPISADEAFAQSILNVSIFGDERDKIVAKWNYLQATWGTGKMFYSQS----- 265

  Fly  7886 TLPSDFT------------------------------------TRPHLEQTTESTRDVLTTRP-F 7913
            ..|.|.|                                    .:||.:|..::...:..::| .
  Fly   266 AAPVDITPENVMCRFKAIGYSRMPGKDNKLGLVALNFCRELSAVKPHQQQVIQTLHSLFGSKPNM 330

  Fly  7914 ETSTPSPVSLET---TVPSVTSETSTNVPIGSTGGQVTE------QTTAPPSVRTTETIVKSTHP 7969
            .....|...||.   .:.....|...:.|..|.....||      |.|..|.:.....:
  Fly   331 LVHIDSIKELENKKCQIVIYVEEKLQHAPNESKRILATELSNYLNQATLKPQLNNLGVV------ 389

  Fly  7970 AVSPDTTIPSEIPATRVPLESTTRLYTDQTIPPGSTD----RTTSSERPDESTRLTSEESTETTR 8030
                      |..|..:|.|...|.|.:.  ||...|    |..:|:.||.:..:
  Fly   390 ----------EALALVLPDEDQLREYLEN--PPRGVDPRMWRQANSDNPDPTLYI---------- 432

  Fly  8031 PVPTVSPRD--------ALET--------TVTSLITETTKTTSGGTPRGQVTERTTKSVSELTTG 8079
            |||.|...|        ..||        .|.|.:||..|..:  |...::.|...| ::|| :.
  Fly   433 PVPMVGFNDLKWRVKCQEQETDTHALYIKKVESELTELKKRHA--TATAKILEHKRK-LAEL-SH 493

  Fly  8080 RSSDVVTERTMPSNISSTTTVFNNSEPVSDNLPTTIS--ITVTDSPT 8124
            |...::.::.....:.::.|      |..:.|.|.:.  :.|..:||
  Fly   494 RILRIIVKQECTRKVGTSLT------PEEEALRTKLQNMLAVVSAPT 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395	80/448 (18%)
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572	17/93 (18%)
		DUF4758	7798..7979	CDD:292572	40/272 (15%)
		DUF4758	7946..8126	CDD:292572	43/207 (21%)
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Nup54	NP_610783.1	Nucleoporin_FG	<5..>64	CDD:290362	16/85 (19%)
		Nucleoporin_FG	121..>196	CDD:290362	15/102 (15%)
		Nup54	412..546	CDD:290585	30/143 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910