DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and Unc-89

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster


Alignment Length:2636 Identity:468/2636 - (17%)
Similarity:779/2636 - (29%) Gaps:834/2636 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  5985 ESPETPTTLPSDFITRPH---------SEQTTESTRDVPTTRPFEASTPSPASLKTTVPSVTSEA 6040
            ::||..:.||.|.  :||         :|.::...:|| |.:...|.     .||.....:.||:
  Fly   352 KAPEANSFLPIDI--KPHGPEAHLTWFNEISSHINQDV-TLQEHNAD-----DLKVDASQIASES 408

  Fly  6041 TTNVPIGSTGQ----RIGTTPSESPETPTTLPSDFTTRPHSEKTTESTRDVPTTRPFETSTPSPA 6101
            ...:.:....:    .:...||:..|      :.|.::...|:.....:::              
  Fly   409 ELILHLPQRAEAHDPNLSVRPSDVAE------NYFLSKETKERLQHEQQEL-------------- 453

  Fly  6102 SLETTVPSVTL----ETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSES 6162
             |:....::.|    :::.:|...:...::|.....|.||||..  |.....|.......||.:.
  Fly   454 -LKLEQEAIELYKKQQSSKSVSSKTESVEITSSQVKSSSEVRKV--VSPPPPPQAQVKEVTPVKV 515

  Fly  6163 PETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQ 6227
            ..:|..|.:.|                   |.:.:||.|.      |.|.:.....|        
  Fly   516 VSSPPPPKEIT-------------------PAKVATPPPQ------PQVVTSPVKEV-------- 547

  Fly  6228 VTGQTTAPPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEQTTESTRDVPT 6292
                  |||.:.|......:...||:|....:||...|....:|.   :..||::.         
  Fly   548 ------APPPQPRAVASPAKEVTPSQSEPVKAPSPIKEVRKEVPP---SASHSKEV--------- 594

  Fly  6293 TRPFEASTPSPASLKTTV-PSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRV-EESTLPSR 6355
                      .|.:.|.: .|:|...:|.|..|.:            ||:|..|.| |||:|..:
  Fly   595 ----------EALVATEIRESLTETRSTVVESGQS------------SEIREEIVVTEESSLEGK 637

  Fly  6356 STDRTTPSESPETPTTLPSDFTTRPHSEKTTESTRDVPTTRPFETSTP-----SPASLETTVP-S 6414
               :....|...:|.::|.                 :...||.|...|     .|..|:..|. |
  Fly   638 ---QVVALEREPSPCSIPK-----------------IQVYRPVECENPVVTKHKPIELKDIVGYS 682

  Fly  6415 VTLETTTSVPMGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTSPS----ESPETPTTLP 6475
            .:|....:.|.|.:.|:..|.:.........||  ..:.|.:.:.||:..:    :|...|..:|
  Fly   683 ESLRDGDTAPAGGSPGRQQGYSANITDHASLTI--WNNRLANIAGDRSGANQHLQQSGPPPPPIP 745

  Fly  6476 SDFITRP---------HSEKTTESTRDVPTTRPFEASTPSSASSGNNCSISYFRNHYKCSNRFNR 6531
            .:|...|         ..|.|.|..  :...||                                
  Fly   746 PNFTRMPGFFQPLPLIAYETTIEIL--IVKARP-------------------------------- 776

  Fly  6532 SADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFE-----ASTPSP--------ASL 6583
                  ||..|..|  |:......|:|...:.|::.     ||     ||:.:.        .|:
  Fly   777 ------PSPPPPPP--PTIKRVLVHTESLEQKTQNF-----FEGIYDAASSDTSLRNAKQKIRSI 828

  Fly  6584 ETTVPSVTSETTTNVPIGSTGGQVTGQTT---------APPSEVRTTIRVEESTL---------- 6629
            ::||  :.|:.:||.      .|.|.|..         .||.:.|....:.|..:          
  Fly   829 KSTV--LKSKDSTNY------AQDTVQKAKARDFLHIFTPPVKKRPIYEIVEEPVNIFELEGDYT 885

  Fly  6630 PSRSTDRTTPSESPETPTILPSDFTTRP---------HSDQTTESTRDVPT-TRPFEASTPRPVT 6684
            .|.:.|...||          :||..|.         :|..:..|||...| ||.::..|....|
  Fly   886 ESIADDFREPS----------ADFEARGQSVGGMDDYYSGYSRASTRRYETKTRDYDRGTSYDST 940

  Fly  6685 LETAVPSVT----------LETTTNVPIGSTGGQVTGQTTA-------TPSEVRTTIRVEESTLP 6732
            :|.:...::          :|..:::       ..||:|.:       :.:|.|.:..|.||...
  Fly   941 VERSQYGISSRRDRSSVDKVEARSSL-------LATGRTESRAASRAESRAESRASYSVAESRAG 998

  Fly  6733 SRSTDR---TTPSESPETPTTLPSDFTTRPHSDQTTE---STRDVP-------TTRPFE------ 6778
            .||:.|   ..|..|.:.|..:....:.:....:|..   ..:|.|       ..:|.|      
  Fly   999 IRSSSRLQEDRPLRSVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADR 1063

  Fly  6779 -ASTPSPAS---------LETTVPSVT------SETTT---NVPIGSTGGQVTEQTTSSPSEVRT 6824
             ..|.:|.:         .||...:.|      |||||   .:.:|...|....:|.:.|:.:  
  Fly  1064 ITQTAAPMNSYRLDIKNCSETDAGTYTIRAQSASETTTVSAQLAVGQAPGHDETKTNTEPAFL-- 1126

  Fly  6825 TIGLEESTLPSRSTDR--TSPSESPETPTTLPSDFITRPHSDQTTESTRD----------VPTTR 6877
             :.|:::.:...:..|  ......|:.......|......::...:..||          :...:
  Fly  1127 -VSLKDAEMIENTLFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQIIRDKDYLGFYELVIADVQ 1190

  Fly  6878 PFEASTPSPASL----ETTVPSVTSETTTNVPIGSTGGQVTEQTTS------------SPSE-VR 6925
            ..:|.|.|..:.    |....::.:......|.|:..||:......            .|.| .:
  Fly  1191 KTDAGTYSCKATNKHGEANCEAIATTVEDKNPFGALSGQILPAGEKPVFQWKRNGEEFDPEERFK 1255

  Fly  6926 TTIGLEESTL------------------PSRSTDRTSPS-------------ESPETPTTL---- 6955
            ...|.:|.:|                  ...||...|.|             ..||.||.:    
  Fly  1256 VLFGEDEDSLALVFQHVKPEDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHR 1320

  Fly  6956 -------------------PSDFITRPHSDQTTESTRDVPTTRPFEASTPSSASLE-TTVPSVTL 7000
                               |...:...|..:..:    |.....|......|.||. ..|.:|..
  Fly  1321 EANASIGGSAILELQCKGFPKPAVQWKHDGEVIQ----VDDRHKFMYEDEESMSLVIKNVDTVDA 1381

  Fly  7001 ETTTNVPIGSTG----------------GQVTEQTTSSPSEVRTTIRVEESTLP-----SRSTDR 7044
            ...|...|...|                .::|:.|.|:...::..|.||....|     :...|.
  Fly  1382 GVYTIEAINELGQDESSINLVVKAPPKIKKITDITCSAGETIKMEIEVEGFPQPTVQVTNNGKDV 1446

  Fly  7045 TTPS----------ESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFEAST--PRPVTLQTAV 7097
            |..|          :|.|.......:.......:.:.:::.|:..|..:.:.|  .:||.::...
  Fly  1447 TAESNVKISSSSIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYWSCTVKSKPVIVKNFE 1511

  Fly  7098 LPVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSD 7162
            .........||       |:|.:..:.| |.:.|...:|:.:  :.||......|.....||...
  Fly  1512 SEYIHGEKENV-------QMTVRIDAYP-EAKLTWYHDETEI--KITDSKYTVSSDGNAYTLKIT 1566

  Fly  7163 FTTRPHSDQTTESSRDVPTTQPFESSTPRPVTLETAVPPVT--------SETTTNVP--IGSTGG 7217
            ..||..:.:.|     |..|....|:|.....|....|..|        :|..:||.  :|    
  Fly  1567 GATRVDAGKYT-----VKATNEHGSATSSTQLLIKCAPEFTHKLKNITVAEGDSNVELVVG---- 1622

  Fly  7218 QVTEQTTPSPSEVRTTIRIEESTFPSRSTDRTTPSE--SPETPTTLPSDFTTRPHSDQTTESTRD 7280
             |.....|........|.|:|.....|..:.....:  ..:..|.:..::|.:..:|........
  Fly  1623 -VDAYPRPHAKWYIDGIEIDEKRNDFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDNC 1686

  Fly  7281 VPTT----------RPFESSTPRPVTLEIAVPPVTSETTTNVAIGSTGGQVTEQTTSSPSEVRTT 7335
            |.|.          :..|....:..|||:   .|.||....:.....|.::.|......|  |.|
  Fly  1687 VVTVNCKPKVKRGLKNVEVQEGKSFTLEV---EVYSEPEAKIKWFKDGHEIYEDARIKIS--RDT 1746

  Fly  7336 IRVEESTLP---SRSTD------RTTPSESPETPTTLPSDFTTRPHS-DQTTESTRDVPTTRPFE 7390
            .|:|...|.   :|:.|      :.|......|.|...:..|:...| :||...|....|..|.|
  Fly  1747 QRIENYYLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEE 1811

  Fly  7391 ASTPSPASLET----TVPSVTLE---TTTSVPMGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSR 7448
            .:.|....::.    :..||.|:   ..|.:|.........|:...|......|:..:...|..:
  Fly  1812 GAVPEIVHVDVFQQHSYESVPLKYEVIATGIPKPEAIWYHDGKPITPDKHTAITVDGDHYKLEVQ 1876

  Fly  7449 STDRTPPSESPETPTTLPSDFTTRPHSDQTTESS---------------RDVP------------ 7486
            |.|..   ::.|....:.:....:.|..:.:.|.               :|:.            
  Fly  1877 SLDLV---DAGEYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGPGLKDIKVNKGDKVCEPVV 1938

  Fly  7487 -TTQPFESSTPRPVTLEIAVPPVTSETTTNVPI-----GSTGGQVTGQTTATPSEVRTTIGVEES 7545
             |..|    .|..|.|:...|.|   .|.||.:     .:..|.|         :...|:.:.|:
  Fly  1939 FTADP----APEIVLLKDGQPVV---ETNNVKLKVDKKDAENGLV---------QYTCTLNILEA 1987

  Fly  7546 TL-PSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVP-TTRPFEA---STPSP----- 7600
            .: .|...:....::..|..|:...|...:|......: |:.:| .|..|||   :.|.|     
  Fly  1988 EIKDSGRYELKVKNKYGELVTSGWIDVLAKPEISGLND-TKCLPGDTICFEALVQANPKPKVSWT 2051

  Fly  7601 ASLETTVPSVTLETTTNVPIGS-----------TGGQVTGQTTATPSEVRTTIGVEESTLPSRST 7654
            ...|........|...:|....           ..|:.|  .|||.||.|..:....:.|..:.|
  Fly  2052 RGNENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYT--ITATNSEGRAAVDFNLAVLVEKPT 2114

  Fly  7655 DRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTP-------RPVTLETAVPSV 7712
            ....|...        |....||.|.:.......:||...|:...|       :|...:......
  Fly  2115 FIVQPESQ--------SIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINKPGKDKLYAKED 2171

  Fly  7713 TSETTTNVPIGSTVTSETTTNVPIGS---TGGQVAGQTTAP---------PSEVRTTIR------ 7759
            |.:.|..  |.|.:..::.....:|:   ......|.|.||         ||.|:....      
  Fly  2172 TKKGTDQ--IESVLDIKSFRENDVGAYTCVATNEIGVTKAPFKLAMLSLAPSFVKKLDNALDVLQ 2234

  Fly  7760 ---------VEESTLPS----RSADRTTPSESPETPTT------------LPSD------FTTRP 7793
                     |:.|.||:    :..|...||||.:..|.            .|:|      ..:.|
  Fly  2235 GEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKLIISNP 2299

  Fly  7794 HSEQTTESTRDVPT-------TRPFEAST---PSPASLETTV--------------------PSV 7828
            |.|:.......|..       .:|..:.|   ..|..||..|                    |.:
  Fly  2300 HGEKVALCAVAVKPEEMQPKFLKPITSQTVVVGEPLKLEAQVTGFPAPEVKWYKDGMLLRPSPEI 2364

  Fly  7829 TSETTTNVPIG-------------------STGGQLTEQSTSS--PSEVRTTIRVEESTLPSRST 7872
            ....:.|..||                   :.||::...|...  |.|.:.....|   |...|:
  Fly  2365 NFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEIEGVSKVEIVPKESKPVFVAE---LQDASS 2426

  Fly  7873 DRTFPSESPEKPTTLPSDFTTRPHL-------EQTTESTRDVLTTRPFETSTPSPVSLETTVP-- 7928
            ...||.:...|....|     :|.|       |...:::...:...|..:|:   :.:|.|.|  
  Fly  2427 IEGFPVKMDIKVVGNP-----KPKLQWFHNGHEIKPDASHIAIVENPDNSSS---LIIEKTAPGD 2483

  Fly  7929 SVTSETSTNVPIGSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATRVPLESTTR 7993
            |...|.....|.|||.                                             |..:
  Fly  2484 SGLYEVIAQNPEGSTA---------------------------------------------SKAK 2503

  Fly  7994 LYTDQTIPPGSTDRTTSSERPDESTRL---TSEESTE-------TTRPVP---------TVSPRD 8039
            ||    :.| ..|.|.:.|.|...:.|   .::|..|       .:.|:|         |::|.:
  Fly  2504 LY----VAP-KADETATEEAPQFVSALRDVNADEGQELVLSAPFISNPMPEVIWSKDGVTLTPNE 2563

  Fly  8040 ALETT-----VTSLITETTKTTSG------GTPRGQVTERTTKSVSELTTGRSSDVVTERTMPSN 8093
            .|..|     :...|.......||      ..|.|:.:.....:|.::   ....|.|::     
  Fly  2564 RLLMTCDGKHIGLTIKPAEAADSGNYTCLLANPLGEDSSACNANVRKV---YKPPVFTQK----- 2620

  Fly  8094 ISSTTTVFNNSEPVSDNLPTTISITVTDSPTTVPVP 8129
            ||....||.|:.    .:|.|:|        .||.|
  Fly  2621 ISDQQQVFGNNA----KIPVTVS--------GVPYP 2644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395 76/429 (18%)
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572 36/202 (18%)
DUF4758 6181..6360 CDD:292572 36/180 (20%)
DUF4696 6339..6999 CDD:292395 151/860 (18%)
DUF4758 6662..6839 CDD:292572 44/232 (19%)
DUF4758 6764..6941 CDD:292572 39/258 (15%)
DUF4758 6866..7045 CDD:292572 43/281 (15%)
DUF4758 6968..7179 CDD:292572 43/244 (18%)
DUF4696 7024..7569 CDD:292395 113/634 (18%)
DUF4758 7172..7383 CDD:292572 48/242 (20%)
DUF4696 7330..7964 CDD:292395 149/820 (18%)
DUF4758 7400..7587 CDD:292572 35/227 (15%)
DUF4758 7538..7707 CDD:292572 38/196 (19%)
DUF4758 7798..7979 CDD:292572 37/240 (15%)
DUF4758 7946..8126 CDD:292572 33/209 (16%)
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134 10/38 (26%)
Atrophin-1 <493..690 CDD:331285 57/291 (20%)
TonB_N 502..>596 CDD:318287 26/154 (17%)
I-set 1017..1108 CDD:333254 16/90 (18%)
I-set 1123..1212 CDD:254352 11/91 (12%)
I-set <1236..1299 CDD:333254 9/62 (15%)
I-set 1313..1403 CDD:254352 14/93 (15%)
Ig_3 1406..1487 CDD:316449 12/80 (15%)
I-set 1499..1595 CDD:254352 23/110 (21%)
I-set 1599..1690 CDD:333254 16/95 (17%)
I-set 1694..1786 CDD:254352 20/96 (21%)
I-set <1836..1903 CDD:333254 10/69 (14%)
I-set 1922..2005 CDD:333254 16/98 (16%)
I-set 2018..2108 CDD:333254 20/92 (22%)
I-set 2113..2214 CDD:333254 20/110 (18%)
I-set 2220..2302 CDD:254352 17/81 (21%)
I-set 2318..2408 CDD:254352 13/89 (15%)
I-set 2415..2506 CDD:254352 24/150 (16%)
I-set 2519..2608 CDD:254352 15/88 (17%)
I-set 2615..2696 CDD:254352 13/47 (28%)
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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